Scientific breakthroughs begin with investments in promising researchers. Congratulations to the 2026 cohort of King Trust Postdoctoral Fellowship Program Awardees, who will receive two years of fund...

To cope with the threat of genome instability, cells have evolved an intricate network of mechanisms ranging from cell cycle checkpoints to specialized DNA repair pathways known as the DNA damage res…

Alternative polyadenylation (APA) generates transcript isoforms with variable 3′ untranslated regions (UTR) lengths, yet its role in DNA damage respon…

Senior Research Technician- Chowdhury Lab job

Bratt, Kilgas et al. describe the SAR-driven design of CAS-010, a selective USP28 probe, alongside a control compound and an inhibitor-resistant mutant. They show that USP28 inhibition mimics p53 path...

Antagonistic activities of the 53BP1 axis and the tumor suppressor BRCA1-BARD1 determine whether DNA double-strand breaks (DSBs) are repaired by end joining or homologous recombination. We show that t...