iiinova — where your digital self keeps evolving

Irene Chiolo @chiololab.bsky.social · 12/04/2026

RPA as a master regulator of BIR! Read all about it in the recent study from the Rass lab.

Reposted by Irene Chiolo

Uli Rass @u-rass.bsky.social · 11/04/2026

An in-press version of our latest paper in @natcomms.nature.com on phospho-activated protein-protein interactions with ssDNA-binding protein RPA during BIR. If your favorite pathway involves RPA, this may be for you! Thanks to the lab, collaborators & @ukri.org! www.nature.com/articles/s41...

Nature Communications banner with title of latest paper from the Yates, Oliver, and Rass groups at the Genome Damage and Stability Centre, University of Sussex: "Break-induced replication is enhanced by a phospho-activated RPA-binding module in Pol32".

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Reposted by Irene Chiolo

Valentina Baderna @valentinabaderna.bsky.social · 08/04/2025

Happy to share the latest story from @arnaudkr.bsky.social's lab @embl.org! With @guidobarzaghi.bsky.social, we used Single Molecule Footprinting to quantify how often chromatin is accessible at enhancers after TF and chromatin environment changes! Check our preprint bit.ly/3XQMFxN + thread ⬇️ 1/11

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raleksandrov.bsky.social @raleksandrov.bsky.social · 07/04/2025

Easily one of the most beautiful live-cell imaging papers out there! Amazing contribution to chromosome tracking during mitosis with huge prospects for further discoveries concerning chromosome behavior. Check it out @naturecellbiology.bsky.social

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Reposted by Irene Chiolo

Edward Nirenberg @enirenberg.bsky.social · 29/03/2025

Peter Marks’s resignation letter. Everyone should read this.

Peter Marks, MD, PhD
Director, Center for Biologics Evaluation and Research U.S. Food and Drug Administration
10903 New Hampshire Avenue
Silver Spring, MD 20903
March 28, 2025
Sara Brenner, MD, MPH
Acting Commissioner of Food and Drugs
U.S. Food and Drug Administration
10903 New Hampshire Avenue
Silver Spring, MD 20903
Dear Dr. Brenner:
It is with a heavy heart that I have decided to resign from FDA and retire from federal service as Director of the Center for Biologics Evaluation and Research effective April 5, 2025. I leave behind a staff of professionals who are undoubtedly the most devoted to protecting and promoting the public health of any group of people that I have encountered during my four decades working in the public and private sectors. I have always done my best to advocate for their well-being and I would ask that you do the same during this very difficult time during which their critical importance to the safety and security of our nation may be underappreciated.
Over the past years I have been involved in enhancing the safety of our nation's blood supply, in advancing the field of cell and gene therapy, and in responding to public health emergencies. In the last of these, during the COVID-19 pandemic I had the privilege of watching the vision that I conceived for Operation Warp Speed in March 2020 in collaboration with Dr. Robert Kadlec become a reality under the leadership of HHS Secretary Azar and President Trump due to the unwavering commitment of public servants at FDA and elsewhere across the government. At FDA, the tireless efforts of staff across the agency resulted in remarkably expediting the development of vaccines against the virus, meeting the standards for quality, safety, and effectiveness expected by the American public. The vaccines undoubtedly markedly reduced morbidity and mortality from COVID-19 in the United States and elsewhere. Many of these same individuals applied learnings from the pandemic during a flawless response helping…

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Reposted by Irene Chiolo

Fusion Conferences @fusionconf.bsky.social · 25/03/2025

📢The programme for #DDRCT25 is now available! Visit our website to explore the exciting sessions, speakers, and key topics we have in store. ➡️Check it out here: fusion-conferences.com/conference/177

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Reposted by Irene Chiolo

Petr Cejka @cejkalab.bsky.social · 25/03/2025

Check out our review on DNA end resection! With Raphael Ceccaldi, www.nature.com/articles/s41...

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Reposted by Irene Chiolo

Mekhail Lab at U. Toronto 🍁🇨🇦 @karimmekhail.bsky.social · 24/03/2025

🚨 Excited to announce the 2nd Spatial Genome Organisation Conference! #SGO25 📅 Oct 31–Nov 3, 2025 | 📍 Riviera Maya, Mexico 🪑 Chairs: @altmeyerlab.bsky.social, @chiololab.bsky.social, @karimmekhail.bsky.social 🔗 Registration: fusion-conferences.com/conference/188 Please 🔄 ❤️

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Reposted by Irene Chiolo

Lopes_Lab @lopeslab.bsky.social · 19/01/2025

Landing on Bluesky by sharing the latest preprint from the lab: nucleoplasmic Lamin A/C modulates RECQ1-mediated fork restart upon mild genotoxic stress, by regulating heterochromatin marks and ADP-ribosylation levels at replication factories www.biorxiv.org/content/10.1...

biorxiv.org

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels

Mild replication interference is a consolidated strategy for cancer chemotherapy. Tolerance to mild replication stress (RS) relies on active fork slowing, mediated by transient fork reversal and RECQ1...

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Reposted by Irene Chiolo

EMBL Events @events.embl.org · 23/01/2025

📣 Join us for #EESNucleus 🧬 Explore the dynamic world of the nucleus at the new EMBO | EMBL Symposium. From nuclear mechanics to pathomechanisms, join the conversation shaping modern cell biology. 🗓️ 18 – 21 November 2025 📥 Submit your abstract by 26 August 👉 s.embl.org/ees25-07-bl

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Reposted by Irene Chiolo

Denis Wirtz @deniswirtz.bsky.social · 09/03/2025

As federal funding for research is uncertain, we need to diversify funding sources for our PhD students. Here is a comprehensive list of >160 PhD fellowships and funding opportunities, mostly from private foundations and scientific societies. Download it here: research.jhu.edu/rdt/funding-...

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Reposted by Irene Chiolo

Lopes_Lab @lopeslab.bsky.social · 17/03/2025

Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇

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Reposted by Irene Chiolo

Cees Dekker @ceesdekker.bsky.social · 16/01/2025

New discovery from our #CDlab reported in Cell @cp-cell.bsky.social today: SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion! www.sciencedirect.com/science/arti... 1/

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Tony Cesare @thecesarelab.bsky.social · 17/03/2025

1/Out today in @naturecomms.bsky.social, “A CPC-shelterin-BTR axis regulates mitotic telomere deprotection”. Here we identify the mechanism that unwinds telomere-loops (t-loops) during mitotic arrest to activate the DNA damage response and signal mitotic stress. www.nature.com/articles/s41....

nature.com

A CPC-shelterin-BTR axis regulates mitotic telomere deprotection - Nature Communications

Here the authors reveal how telomeres signal mitotic stress. A key protein network alters their structure exposing telomere ends to signal mitotic stress, ultimately triggering a controlled DNA damage...

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