Journal of Cell Biology (JCB) publishes advances in any area of basic cell biology as well as applied cellular advances in fields such as immunology, neurobiology, metabolism, microbiology, developmen...

We present a foldamer strategy to downsize the histone H3-H4 quaternary structure into high-affinity, medium-sized binders (∼2 kDa) for the histone chaperone ASF1. Our peptide-oligourea chimeras, des....

Abstract. Suppression of single-stranded DNA (ssDNA) gap accumulation at replication forks has emerged as a potential determinant of chemosensitivity in ho

Homologous recombination (HR) is essential for the repair of DNA double-strand breaks and the restart of stalled replication forks. A critical step in HR is the formation of Rad51 nucleofilaments, whi...

Author summary Protein-RNA interactions are crucial to many biological functions and can play a role in diseases. We adopted a computational strategy to analyze and compare experimental 3D structures ...

What is a 3D structure? Some applications The foundations and origins of structural biology Knowing and preparing your sample Choising a structural biology method Expérimental methods : NMR 1 Choose y...