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Can foldamers mimic extended protein surfaces?
Our peptide-oligourea foldamers reproduce the histone H3-H4 interface on the histone chaperone ASF1, combining nanomolar affinity, stability & cell permeability.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Downsizing the Histone H3–H4 Quaternary Structure Into Foldamer Mimetics Yields High‐Affinity and Cell‐Permeable Ligands of ASF1
We present a foldamer strategy to downsize the histone H3-H4 quaternary structure into high-affinity, medium-sized binders (∼2 kDa) for the histone chaperone ASF1. Our peptide-oligourea chimeras, des....