This short video uses the example of adenosine and caffeine to introduce two key concepts in pharmacology: the agonist and the antagonist. Both, adenosine, and caffeine molecules bind to adenosine receptors on the neurons. Caffeine, the antagonist, blocks the receptor, while adenosine, the agonist, produces the biological response upon binding.

PDB-101: Training, Outreach, and Education portal of RCSB PDB

Scripps Research scientists developed a blueprint for stabilizing key influenza proteins and are using them to make next-generation vaccine candidates.

UD researchers identify molecular switch that could make antibiotics more effective against drug-resistant bacteria

It's International Ataxia Awareness Day.

PDB-101: Training, Outreach, and Education portal of RCSB PDB

The story behind the 100-year-old discovery that continues to render Nobel Prizes.

Cell-clogging amyloids form when proteins improperly aggregate

Abstract. Born in London in 1953 and raised in Australia, Phil Bourne spent over four decades in science moving across scales: from crystal structures to t

Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils.

Nature - Researchers detect more than 1,000 overlooked microproteins in human brain tissue, including some that are altered in Alzheimer’s disease.

Researchers at UC San Diego have demonstrated that one of biology’s most essential enzymes can accurately read and transcribe an expanded genetic alphabet containing eight DNA letters instead of the four used by all known life.

Pain is one of the most trying experiences of life. On the cellular level it is communicated via special neuronal pathways. On the molecular level, however, pain is communicated like any other sensation, via a set of electrical and chemical signals facilitated by complex molecular machinery. These signals can be modulated by opioids, causing us to feel less pain, or no pain at all. Learn how opioids activate the G-proteins which in turn interact with other proteins to edit the pain signal.

Ten research teams were honored Thursday at a satirical science awards ceremony that was hosted outside the U.S. for the first time due to travel concerns.

PDB-101: Training, Outreach, and Education portal of RCSB PDB

Scripps Research scientists develop a blueprint for stabilizing key influenza proteins and using them to make next-generation vaccine candidates.

For nearly a century, scientists have known that phase shifting an electron beam could radically improve electron microscopy. They’ve finally found a reliable way to do it.

Nature - Nobel laureate persisted despite widespread derision and revolutionized structural biology by protecting fragile crystals.

Learn how metalloprotein data have been enhanced to support the Findability, Accessibility, Interoperability, and Reusability of PDB data

PDBx/mmCIF forms the basis of wwPDB data deposition, annotation, and archiving of PDB structure data. This PDB-101 resource is an introductory guide.

By Sandhya Subramanian, Karla J. F. Satchell, Alfa Herrera, and Krystle J. McLaughlin

A machine-learning framework developed by MIT biologists aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.

New approach reveals proteins’ structures and enables next-gen flexible biomaterials

Insulin is stored in small crystals inside pancreatic beta cells.

RCSB PDB is looking for a software database administrator/database specialist and an IT Infrastructure Lead to support the ongoing operations and growth of our IT infrastructure.

Learn how metalloprotein data have been enhanced to support the Findability, Accessibility, Interoperability, and Reusability of PDB data

Bacterial communities glued together and protected by biological polymers

Atomic structures of the ribosomal subunits reveal a central role for RNA in protein synthesis

Cells capture and utilize many forms of energy to power their molecular processe

Nature - The model can modify existing proteins using a probability approach.

Improved accuracy and annotation metal-containing PDB Entries and CCDs are now available in remediated PDB data.

PDB-101: Training, Outreach, and Education portal of RCSB PDB

AI agents that can model the human process of research will accelerate discoveries in science.

wwPDB has extended PDB IDs to 12 characters with a prefix `pdb_' followed by eight alphanumeric characters in lower case (for example pdb_1000axyz). A beta version of the PDB Archive (https://files-beta.wwpdb.org), with extended PDB IDs and an improved directory structure, is now available to help communities adopt extended PDB IDs and the PDBx/mmCIF format.

Scripps Research scientists and colleagues show how drugs that eliminate certain disease-driving proteins can be discovered systematically rather than by chance.

Led by a Brazilian researcher, a study published in Nature shows that molecules with nearly identical three-dimensional structures can exhibit completely different behaviors over time.

Learn how metalloprotein data have been enhanced to support Findability, Accessibility, Interoperability, and Reusability of PDB data

Phytase is used in agriculture to mobilize indigestible phosphate compounds in livestock feed.