Retrotransposons can infect neighboring cells using a mechanism that relies on a small fusogen-like protein rather than on the envelope protein that is typically required for infection.

High mutation rates erode viral sequence similarity, obscuring deep evolutionary history. While protein structure is far more conserved than sequence, its use in evolutionary studies has historically ...

High mutation rates erode viral sequence similarity, obscuring deep evolutionary history. While protein structure is far more conserved than sequence, its use in evolutionary studies has historically been bottlenecked by experimental determination. The recent revolution in artificial intelligence (A...

A University of Minnesota–led multi-institutional research team has discovered a highly potent small molecule that blocks Ebola virus entry by stabilizing the virus's entry protein and provides…

Cell entry of nonenveloped animal viruses requires translocation of a macromolecular assembly across a cellular membrane. Double-stranded RNA viruses introduce into the target cell an inner capsid par...

There is still limited data reported on virus diversity in South American bats. In this study, the authors report a divergent betacoronavirus with a functional furin cleavage site in South American ba...

Total cases have passed 6,000 in DR Congo.

Liang et al. show how enterovirus D68 uses the respiratory receptor MFSD6 and sugar modifications to enter cells, revealing a checkpoint that primes the virus for infection.

A genomic screen reveals homologues of ESCRT components in mirusviruses that infect unicellular aquatic eukaryotes.

Delhi and NCR witness a significant rise in H1N1 (swine flu) and dengue cases due to humid monsoon weather. Experts urge preventive measures and timely medical consultation.

Anthropic published a wet-lab-validated protein binder result on 18 August 2026, then disclosed an 11-month biosecurity classifier gap. The two stories together explain why the world's most capable pr...

Nature - Two research teams mined genomic data from bacteria to create databases containing thousands of antiviral defence proteins that could inspire powerful biotechnologies.

Li et al. identified SCARF2 as an intracellular receptor for HBV entry that directs internalized HBV to nuclear pore complexes and facilitates nucleocapsid release from endosomes.

Initial genomes from May 2026 Bundibugyo Virus Disease Outbreak in the Democratic Republic of the Congo and Uganda, reveal a new spillover event Context On 15 May 2026, the Ministry of Public Health, ...

Concerns raised that cases were caused by a new strain of the virus as African health officials race to coordinate and contain the infection An outbreak of Ebola has killed 65 people in the Democratic Republic of the Congo, according to African health officials. There have been 246 suspected cases of the deadly haemorrhagic fever reported so far in Ituri province, which shares borders with Uganda and South Sudan. Continue reading...

Posted on behalf of the Swiss National Reference Center for Emerging Viral Infections, Geneva University Hospitals and the Institute of Medical Virology, University of Zurich (Partner Laboratory Natio...

In this study, the authors identify circular RNAs replicating in high-temperature hot spring environments and demonstrate that ccc RNA replicons belonging to the Obelisk superfamily are more diverse and widespread than previously recognized, revealing hidden RNA systems in natural environments.

Non-spike changes driving SARS-CoV-2 fitness remain undiscovered. This Primer comments on two PLOS Biology papers that show that evolutionary N gene mutations create a transcription-regulating sequenc...

In a follow-up on the chikungunya outbreak in Argentina, the Argentina National Epidemiological Surveillance System (BEN) reports 268 new cases of chikungunya fever during the week ending April 11.

The database of 200 million protein-structure predictions now includes homodimers, adding new biological relevance.

Marburgvirus glycoprotein binds to the endosomal receptor NPC1 in a distinct orientation with higher affinity compared with Ebola virus glycoprotein, accompanied by fusion-relevant rearrangements, enabling more efficient viral entry.

Proteins assume complex 3D shapes even faster than does DNA, which is a simpler molecule.

Immune systems in animals, plants, and bacteria often rely on intracellular nucleotide signaling, which viruses can block by sequestering or degrading these signals. We identified structural and bioph...