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Lars-Anders Carlson

@lacarlson.bsky.social
2K followers 307 following 449 posts

Structural virology group leader at Umeå University, Sweden. www.carlsonlab.se

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Lars-Anders Carlson @lacarlson.bsky.social · 19h
Our first-year PhD student is doing cryo-FIB milling today, and uses the gaps to do Southern blotting in parallel. I officially surrender.
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Ben Engel @cellarchlab.com · 13/10/2026
Very nice #TeamTomo learning resource! Thank you for making it all publically available. Well done! 🧪🙌
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Utz Ermel @uermel.bsky.social · 13/10/2026
New on the #cryoET Data Portal: three datasets benchmarking the crossed laser phase plate (xLPP) ⚡ Data by Reza Paraan and the @biohub.org team with collaborators at UC Berkeley. Full credits at the end of the 🧵 cryoetdataportal.czscience.com/depositions/10363
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Lars-Anders Carlson @lacarlson.bsky.social · 13/10/2026
Importantly, the main biological findings related to Tantalosin are robust. My colleague and corresponding author Yaowen Wu has acted very conscientiously in this process and no shadow should fall on him. The paper is being prepared for resubmission. 3/3
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Lars-Anders Carlson @lacarlson.bsky.social · 13/10/2026
The retraction statement is rather brief, so I'd like to add that the contribution of my former PhD student Kasturika Shankar to the project was sound, was never challenged by anyone, and is not the reason for the retraction. 2/3
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Lars-Anders Carlson @lacarlson.bsky.social · 13/10/2026
Recently, a paper that my group co-authored was retracted (PMID: 38635626). Since I was not corresponding author of the paper, I will refrain from longer deliberations, but I also don't want to sweep it under the rug. 1/3
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Lars-Anders Carlson @lacarlson.bsky.social · 13/10/2026
Looking at you, AI
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Lars-Anders Carlson @lacarlson.bsky.social · 13/10/2026
Congratulations to the four Umeå University-led projects funded in this call! www.umu.se/en/news/four...
umu.se
Four projects at the forefront of international research to receive 120 million
The Knut and Alice Wallenberg Foundation is allocating 120 million to four different research projects.
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Knut and Alice Wallenberg Foundation @kawresearch.bsky.social · 13/10/2026
Knut and Alice Wallenberg Foundation is awarding SEK 900 million to 30 research projects that, following evaluations by international experts, have been judged innovative and at the forefront of international research. See the list of granted projects: tinyurl.com/bddfy2j8 #research #science
tinyurl.com
30 outstanding research projects awarded a total of SEK 900 million | Knut and Alice Wallenberg Foundation
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Cahir O'Kane @cahirokane.bsky.social · 11/10/2026
An archaeal genome around the upper size range of mitochondria and chloroplast genomes. Looks like an intracellular parasite with the minimal machinery for autonomous replication and expression, entirely dependent on host metabolism, without host investment in its survival.
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Lars-Anders Carlson @lacarlson.bsky.social · 11/10/2026
Interesting post and comments to it!
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 10/10/2026
Here is the REAL winner of the Nikon Small World in Motion after the AI Monstrosity was removed www.nikonsmallworld.com/galleries/20...
nikonsmallworld.com
A tiny roundworm and a single-celled Dileptus explore their microscopic world | 2026 Small World in Motion Competition
Nguyen Nam Nhat - A tiny roundworm and a single-celled Dileptus explore their microscopic world
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Rita Strack @ritastrack.bsky.social · 10/10/2026
I was confident this would be the outcome following an investigation. Contest-Winning Microscope Video Thrown Out for Using Generative AI share.google/3CrmkbqH0kHT...
share.google
Contest-Winning Microscope Video Thrown Out for Using Generative AI
Ning Xu's winning entry to Nikon Instruments' Small World in Motion competition was ineligible due to AI, a spokesperson for the contest told Gizmodo.
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LabPrudent @prudentlab.bsky.social · 08/10/2026
Delighted to share our lab’s latest paper, published in @science.org , uncovering a new role for Golgi-derived vesicles and phosphoinositides regulating mitochondrial fusion! 👇 www.science.org/doi/10.1126/...
science.org
Golgi-derived vesicles containing PI(3,4)P2 drive mitochondrial fusion
Mitochondria are dynamic organelles that remodel their shape to regulate cell fate. Mitochondrial division involves interactions with the endoplasmic reticulum (ER), lysosomes, and trans-Golgi network...
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Lars-Anders Carlson @lacarlson.bsky.social · 09/10/2026
Cryo-tides, and now cryoSHIELDs. Maybe we need to get a peptide synthesiser to the EM facility?
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Przemek Dutka @przemekdut.bsky.social · 08/10/2026
Our latest development is now on bioRxiv: cryoSHIELDs — amphipathic peptide additives that make cryo-EM grid prep far more reliable. Tested across 24 protein systems, they enabled the first ABCC6 structure and GPCR–G protein structures at just 0.1–0.5 mg/mL! www.biorxiv.org/content/10.6...
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Nobel Prize @nobelprize.org · 09/10/2026
Wangari Maathai was a Nobel Prize laureate of many firsts: the first woman in East and Central Africa to earn a doctorate degree, the first female professor in Kenya and the first African woman to be awarded the Nobel Peace Prize. Stay tuned – later today we will announce the 2026 peace prize.
Wangari Maathai wearing a colourful blue and green dress with a matching head scarf. She is holding a small sapling in a paper pot.
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Nature Methods @natmethods.nature.com · 02/10/2026
Graphene reservoirs formed over perforated support films precisely control ice thickness during cryo-EM sample preparation. www.nature.com/articles/s41...
nature.com
Control of ice thickness in cryo-EM via confinement - Nature Methods
This study explores the use of graphene reservoirs formed over perforated supporting films as a method to precisely control ice thickness during cryo-EM sample preparation.
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Stephen Graham's Lab @atomicvirology.bsky.social · 08/10/2026
Now published in Science Advances @science.org Herpes simplex virus has a single protein that completely silences neuronal activity by removing ion channels from the cell surface 🧠🤫⚡ www.science.org/doi/10.1126/... Bluetorial of the preprint 👇
science.org
Herpes simplex virus pUL56 abolishes neuronal activity by removing voltage-gated ion channels from the plasma membrane
Herpes simplex virus 1 (HSV-1) infections of the central nervous system cause encephalitis and are associated with increased risk of neurodegeneration, yet the molecular consequences of lytic infectio...
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Lars-Anders Carlson @lacarlson.bsky.social · 07/10/2026
Does the OpenAI maths "dump" mean humans should focus more on formulating maths problems than on the technicalities of solving them? That is not necessarily bad, or? "Computers are useless, they can only provide answers." (Picasso)
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Davide Castelvecchi @castelvecchi.bsky.social · 07/10/2026
My latest, on OpenAI's dump www.nature.com/articles/d41...
nature.com
OpenAI posts 700 maths preprints online: mathematicians are up in arms
The firm used unreleased models to tackle hundreds of high-profile problems.
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Debnath Ghosal @debnathghosal.bsky.social · 07/10/2026
When imaging at high mag using cryo-ET, field of view reduces. How to overcome this limit? How do we get a "bird’s-eye view" without compromising resolution? Our very own @HamishBrown has a solution to this: “montage tomography with a rectangular beam!” www.biorxiv.org/content/10.6...
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Lars-Anders Carlson @lacarlson.bsky.social · 07/10/2026
But "evil" caught my attention!
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EMBL @embl.org · 07/10/2026
The @nordicembl.bsky.social held its annual meeting in Umeå, bringing together scientists from across the Nordics and EMBL. EMBL Director General Tony Hyman opened with a keynote on his vision for EMBL and the future of the Partnership. Read more: www.embl.org/news/connect...
Collage showing the highlights of the 2026 annual meeting of the Nordic EMBL Partnership for Molecular Medicine in Umeå, Sweden. Upper left: MIMS Director Oliver Billker’s toast during the DG reception. Upper right: EMBL Director General Anthony Hyman giving his keynote address. Bottom: Group picture of meeting participants.
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Nobel Prize @nobelprize.org · 07/10/2026
The #NobelPrize in Chemistry 2026 recognises discoveries that have enabled chemists to drive chemical reactions that lead to homochirality.
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Nobel Prize @nobelprize.org · 07/10/2026
We’ll soon discover what revolutionary breakthrough has been awarded this year’s Nobel Prize in Chemistry. Stay tuned.
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Lars-Anders Carlson @lacarlson.bsky.social · 06/10/2026
Umeå can be so serene in early autumn. And yes, that is a giant clothespeg.
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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 05/10/2026
"Photograph 51 was not the result of an experiment in need of analysis, but was refined documentation for calculations that she had already performed on the earlier photograph." link.springer.com/content/pdf/...
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Prof William Ripple @williamripple.bsky.social · 28/09/2026
We invite everyone (nonscientists) to endorse the Declaration of a Planetary Emergency, part of the upcoming World Scientists’ Warning to Humanity: A Third Notice. Add your name and share widely. Endorsement helps show public concern about the future of our planet. forms.gle/vAARd7mv2yS7...
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Nikolai Slavov @slavov-n.bsky.social · 02/10/2026
Comparison of citation metrics. ACS journals (green) and Nature journals (blue). Discuss. 1/
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Nobel Prize @nobelprize.org · 04/10/2026
Six days. Six prizes. 🎉 Keep an eye on our social channels starting Monday 5 October as we reveal the 2026 Nobel Prize laureates. See the full list of announcement dates: www.nobelprize.org/prizes/about/pri…
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RCSB Protein Data Bank @rcsbpdb.bsky.social · 04/10/2026
How X-rays and crystals revealed the true nature of things The story behind the 100-year-old discovery that continues to render Nobel Prizes.
nobelprize.org
How X-rays and crystals revealed the true nature of things - NobelPrize.org
The story behind the 100-year-old discovery that continues to render Nobel Prizes.
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Julian Sale @juliansalelab.bsky.social · 02/10/2026
Congratulations Tanmay, on receiving the @embo.org Gold Medal! @mrclmb.ac.uk @embl.org @dunnschool.bsky.social
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RCSB Protein Data Bank @rcsbpdb.bsky.social · 01/10/2026
October's Molecule of the Month: Celebrating 55 Years of the PDB (on October 20) Enabling the rapid evolution of protein structure prediction and design
pdb101.rcsb.org
PDB101: Molecule of the Month: Celebrating 55 Years of the PDB
Enabling the rapid evolution of protein structure prediction and design
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Lars-Anders Carlson @lacarlson.bsky.social · 01/10/2026
Not sure why but it does tick all the buzzword boxes :)
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Basil Greber @bjgreber.bsky.social · 01/10/2026
Those who had a careful look at the methods section of our work on the #cryoEM structure of the CDK11-cyclin L-SAP30BP complex will have noticed that we added a short peptide to our sample before freezing. If you wonder why...
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Svetlana Dodonova @dodonova-sveta.bsky.social · 30/09/2026
New preprint from Dodonova lab 🔔! Capturing multiple states by cryo-EM❄️, we show for the first time how archaeal RNA Polymerase engages a nucleosome and forms direct contacts with histones! 🧬 Great work by Gabriele & a fantastic collaboration with Dina Grohmann! 🧵 www.biorxiv.org/content/10.6...
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Philipp Radler @radler92.bsky.social · 01/10/2026
The first paper of my PostDoc in Christa Schlepers group (@archaea-vienna.bsky.social) on the dynamics of Asgard archaea is now out in Nature! www.nature.com/articles/s41... This was a great team effort and I am looking forward to uncover the complex behavior of these cells further!
nature.com
Dynamic protrusions mediate crawling motility in Asgard archaea - Nature
Anoxic live-cell imaging shows actin-dependent crawling motility and dynamic protrusions in Asgard archaea, providing insights into cellular innovations that may have contributed to eukaryotic evoluti...
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Lars-Anders Carlson @lacarlson.bsky.social · 01/10/2026
Crawling Asgard archaea - have to read this one as soon as I find time!
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Hauke Hillen @haukehillen.bsky.social · 30/09/2026
We are looking for a new team member! Interested in structural biology, gene expression and organelles? Then apply now to our open PhD position: umg.recruiting-portal.com/r/z11okjqp6v...
umg.recruiting-portal.com
Institut für Zellbiochemie -- PhD (f/m/d)
PhD (f/m/d)
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Lars-Anders Carlson @lacarlson.bsky.social · 30/09/2026
Well done, Sweden!
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MwahahahahahadScientist @mads100tist.bsky.social · 29/09/2026
Well, there it is. The EU is also going to use slop algorithms to put an artificial number on proposals. This is how we lose. This is a disaster 🧪
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Nikolai Slavov @slavov-n.bsky.social · 30/09/2026
bioRxiv has a dedicated section for negative results. Use it. Share negative results. Your colleagues will appreciate it.
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Asaf Levy @asaflevylab.bsky.social · 30/09/2026
In October we are starting year 8 (I think) of the virtual microbiology journal club (on Zoom) with fantatstic speakers, as usual. Most talks are about bacteria. If you (PIs, trainees, anyone interested in science) want to be included in the mailing list - shoot me an email. alevy@mail.huji.ac.il
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Kiarash Jamali @kjamali.bsky.social · 29/09/2026
Please check out our cool new method, GuideFlip! Optimised for binders against disordered proteins
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Lars-Anders Carlson @lacarlson.bsky.social · 29/09/2026
Science will prevail in the long run, but it is sometimes easier for politicians to make a "difference" in the short run: "Despite recent financial cutbacks, which are estimated to result in an additional 6.6 million new HIV infections and 4.2 million AIDS-related deaths between 2025 and 2029..."
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Lars-Anders Carlson @lacarlson.bsky.social · 29/09/2026
Have fun with it! Are you also planning to use it for volume imaging?
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Rémi Fronzes @fronzeslab.bsky.social · 29/09/2026
CryoFIB SEM installed at the @bic-bordeaux.bsky.social 🍾🎉🍾🎉
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feeb 🔜 BosBAF @magicmooshka.bsky.social · 09/01/2026
it’s come to my attention that my tumblr post has been crossposted to bluesky, so I’m posting it on my account here #AntiAI #GenAI
recently my friend's comics professor told her that it's acceptable to use gen AI for script-writing but not for art, since a machine can't generate meaningful artistic work. meanwhile, my sister's screenwriting professor said that they can use gen AI for concept art and visualization, but that it won't be able to generate a script that's any good. and at my job, it seems like each department says that AI can be useful in every field except the one that they know best.

It's only ever the jobs we're unfamiliar with that we assume can be replaced with automation. The more attuned we are with certain processes, crafts, and occupations, the more we realize that gen AI will never be able to provide a suitable replacement. The case for its existence relies on our ignorance of the work and skill required to do everything we don't.
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RCSB Protein Data Bank @rcsbpdb.bsky.social · 28/09/2026
Structural Biology and Nobel Prizes: Visit PDB-101 to explore connections between Nobel Prizes and more than 50 years of open access to the PDB archive
pdb101.rcsb.org
PDB101: Browse: Nobel Prizes and PDB structures
PDB-101: Training, Outreach, and Education portal of RCSB PDB
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