An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families.

This study introduces iChIP2, a low-input chromatin immunoprecipitation followed by sequencing method that profiles histone post-translational modifications (hPTMs) simultaneously across diverse eukar...

ABSTRACT. C.H. Waddington (1905-1975) was a British biologist and perhaps the major figure in developmental biology between the 1940s and 1960s. He is one of the few pre-molecular-age developmental bi...

61 species, 13 phyla, one simple geometric rule that appears to set when every embryo starts speaking through its own genome.

Nature Reviews Genetics, Published online: 19 May 2026; doi:10.1038/s41576-026-00976-wRed Queen dynamics describe a mode of evolution in which interacting biological entities continually adapt and counteradapt. This Comment discusses the pervasiveness of these dynamics within genomes, which can involve selfish genetic elements, and highlights building evidence that they can even drive compensatory coevolution among subunits of essential protein complexes.

Modern humans increasingly live long enough to experience late-life consequences of genetic and molecular systems shaped by natural selection. In this Review, the authors integrate evolutionary geneti...

Nature Reviews Genetics, Published online: 17 April 2026; doi:10.1038/s41576-026-00952-4In this Review, Sousa-Luís and Carmo-Fonseca discuss the various tools available to detect and quantify alternative splicing, functionally test splice isoforms and investigate the link between genetic variation, splicing and disease.

Nature Reviews Genetics, Published online: 25 March 2026; doi:10.1038/s41576-026-00951-5In this Journal Club, Emilie Brasset highlights a 1995 publication by Prud’homme et al., who designed a clever genetic assay to identify a gene important for TE silencing, which provided a crucial foundation for later studies to unravel the underlying mechanisms.

In this interview, Julia Batki, FMI’s newest group leader, reflects on the early curiosity that drew her to science, why FMI is the right home for her lab, how studying cell clearance could help us un...

Abstract. For more than a century, scientists have worked to characterize, understand, and predict the consequences of mutations. For almost as long, scien

Nature Reviews Genetics, Published online: 25 March 2026; doi:10.1038/s41576-026-00951-5In this Journal Club, Emilie Brasset highlights a 1995 publication by Prud’homme et al., who designed a clever genetic assay to identify a gene important for TE silencing, which provided a crucial foundation for later studies to unravel the underlying mechanisms.

piRNAs are an important genome regulatory mechanism conserved across metazoans. In the nematode C. elegans, piRNA biogenesis evolved several differences from other metazoans. Beltran et al. study the ...

Nature Reviews Genetics - In this Perspective, Maizels and Briscoe discuss the limitations of current models of gene regulatory networks and outline solutions to harness data abundance without...

Identification of ZAD-ZnF genes as key regulators of genome organization during Drosophila embryogenesis.

Giant DNA viruses encode a cap-binding complex homologous to eIF4F, the defining translation-initiation complex of eukaryotes. The viral cap-binding complex is required for viral protein synthesis and...

Nature Reviews Genetics, Published online: 10 February 2026; doi:10.1038/s41576-026-00944-4In this Journal Club, Fumitaka Inoue discusses a 2009 paper by Patwardhan et al. that introduced a massively parallel saturation-mutagenesis assay that leverages high-throughput DNA synthesis and sequencing to quantify the effects of single-nucleotide changes on regulatory element activity.

or, Why all biologists needs data visualization Biology probes form and function of Life. Form is easy to grasp: cells under a microscope, subcellular

Nature Reviews Genetics, Published online: 15 January 2026; doi:10.1038/s41576-025-00928-wAlternative 3′-end processing of nascent RNA, known as alternative polyadenylation (APA), increases transcript diversity and augments post-transcriptional modulation of gene expression. APA profiles are highly dynamic in response to cell growth, differentiation and extracellular cues, and dysregulated APA is a hallmark of human diseases.

ARGONAUTE (AGO) proteins are a highly conserved family of RNA-binding proteins that play central roles in gene regulation and developmental process...

Nature Reviews Molecular Cell Biology - A study that showed that programmed DNA elimination in somatic genomes of ciliates involves excision of intrusive, transposon-derived sequences from genes.