Senior Downing Street officials reach out to thinktanks and pollsters as they look to test backing for reversing Brexit Senior Downing Street officials have been reaching out to thinktanks and pollsters as they look to test public support for the UK rejoining the EU. Aides to Andy Burnham have been talking to EU experts in a range of organisations about how the public would view a promise to rejoin, as momentum builds behind including such a pledge in the next Labour manifesto. Continue reading...

Symbiotic relationships of microorganisms are predicted and cataloged with a machine learning tool.

Using bioinformatics, biochemistry, NMR, as well as the newly characterized enzyme ArmA from methanogenic archaea, we revised the existing knowledge on archaeal peptidoglycan structure. At the same ti...

Ancient symbioses may enable ants to thrive in diverse niches, but how these relationships are regulated remains unclear. This study reveals that some ants can dynamically regulate symbiont-derived be...

Cyclic transcription is a hallmark of the cell cycle. While transcriptional waves in eukaryotes are driven by oscillations in cyclin-dependent kinase (CDK) activity, many archaea have an ordered cell ...

Cyclic transcription is a hallmark of the cell cycle. While transcriptional waves in eukaryotes are driven by oscillations in cyclin-dependent kinase (CDK) activity, many archaea have an ordered cell ...

While the dynamic changes in genome organization in cellular organisms have been well described, the three-dimensional (3D) folding of phage genomes during the infection of their host is extremely lim...

Inside cells, DNA is intimately associated with proteins, forming chromatin. The protein constituents of chromatin vary across the tree of life: histones are the principal building blocks of chromatin...

Ruault et al. reveal how budding yeast telomeres reorganize from peripheral foci to a central hypercluster in long-lived quiescent cells. They show that th

Academic survival guides teach junior researchers how to live with the judgements of senior scholars. No corresponding genre gives young researchers authority to advise the people who judge them.

Structural bioinformatics aims to answer biological questions by considering biomolecular structures at scale. This Perspective argues that now that we have accurate predictions, we need to ask what w...

Archaea and bacteria routinely live side by side in microbial communities and must interact at least on occasion. Whether such cross-Domain interactions are dominated by mutual disregard, co-operation...

DNA replication begins when inactive helicases are switched on to unwind DNA. Here, the authors map this activation in yeast, revealing where DNA first melts and how helicase splitting, factor release...

The emergence of the eukaryotes coincided with the diversification of histone proteins and their post-translational modifications by enzymes that constitute the core of eukaryotic chromatin. Yet the e...

An 8-year soil meta-omic time series shows how mobile genetic elements shape permafrost microbial diversity and impact a range of functions, including carbon and nutrient cycling.

In 1977, Woese and colleagues revealed Archaea as a distinct domain of life. Building on this insight, the discovery of Asgard archaea has strengthened the view that many hallmarks of eukaryotic cell…