The Department of Biology at Stanford University seeks applicants for a tenure-track Assistant Professor in Evolutionary Biology. A successful candidate will conduct research that asks fundamental que...

The gut microbiome changes with age and associates with age-related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requ....

Dönertas Group Website

Turquoise killifish are naturally short-lived vertebrates that serve as a model system for aging. The authors show that killifish exhibit age-related transformation in the immune system, which rapidly...

Cellular senescence lacks a universal marker and varies across cell types, tissues, and stressors, complicating identification. Using SPiDER SA-β-gal labeled single-cell RNA-seq from regenerating mous...

Growing evidence suggests that the gut microbiota is closely intertwined with life-history evolution in a wide range of species, including well-studied model organisms like Drosophila melanogaster. Al...

West Anatolia has been a crucial yet elusive element in the Neolithic expansion from the Fertile Crescent to Europe. In this work, we describe the changing genetic and cultural landscapes of early Hol...

Register now

Fuentealba and colleagues build and validate a DNA methylation clock of intrinsic capacity (IC) to bridge resource-intensive clinical assessments of IC with molecular readouts of aging, highlighting…

Growing evidence suggests that the gut microbiota plays a key role in shaping life history in a wide range of species, including well-studied model organisms like Drosophila melanogaster. Although rec...

Researchers at the Woods Hole Oceanographic Institution (WHOI) and partner institutions, including the Brookfield Zoo Chicago's Sarasota Dolphin Research Program (SDRP), are the winners of the…

Haematopoietic stem cells (HSC) are responsible for blood cell generation and reside in the bone marrow. Here, the authors show that macrophages in the bone marrow originate from embryonic or adult…

Machine learning (ML) combined with diverse omic datasets offers transformative potential for predicting health outcomes and chronic diseases. By leve…

It can be hard to say no to service requests in academia. Nature’s Careers team sought advice on how to ensure researchers don’t get stuck doing unpaid labour.

The Joachim Herz Foundation has granted two doctoral students at the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) an Add-on Fellowship of €12,500 each. These fellowships support interdis...

Our new quantum chip demonstrates error correction and performance that paves the way to a useful, large-scale quantum computer.

Genome-wide analysis and genetic manipulation at loci regulated by p53, E2F4 and RFX7 show that convergent promoters with similar epigenetic features can be co-regulated and simultaneously expressed…

To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...

Welcome to the Nextflow community training portal!

Lifespan is an integrative phenotype whose genetic architecture is likely to highlight multiple processes with high impact on health and aging. Here, we conduct a genetic meta-analysis of longevity…

If there is one development at the moment which I full heartedly enjoy reading about it’s that the remains of what was once called Twitter is seeing a large E𝕏odus. Since a certain billionaire has…

This link will take you to a page that’s not on LinkedIn

RNA abundance quantification has become routine and affordable thanks to high-throughput “short-read” technologies that provide accurate molecule counts at the gene level. Similarly accurate and affordable quantification of definitive full-length, transcript isoforms has remained a stubborn challenge, despite its obvious biological significance across a wide range of problems. “Long-read” sequencing platforms now produce data-types that can, in principle, drive routine definitive isoform quantification. However some particulars of contemporary long-read datatypes, together with isoform complexity and genetic variation, present bioinformatic challenges. We show here, using ONT data, that fast and accurate quantification of long-read data is possible and that it is improved by exome capture. To perform quantifications we developed lr-kallisto, which adapts the kallisto bulk and single-cell RNA-seq quantification methods for long-read technologies. ### Competing Interest Statement The authors have declared no competing interest.

<div style = "width:60%; display: inline-block; float:left; "> Lessons from Will Hunting and McGayverIn the world of data science, data cleaning is often seen as one of the most time-consuming and least glamorous tasks. Yet, it’s also one of the most critical. Without clean data, even the most sophisticated algorithms and models can produce misleading results. This ...</div><div style = "width: 40%; display: inline-block; float:right;"><img src=' https://medium.com/_/stat?event=post.clientViewed&referrerSource=full_rss&postId=da37e4dcfe24' width = "200" style = "padding: 10px;" /></div><div style="clear: both;"></div>

Nature Reviews Microbiology - In this Review, Kunath et al. explore the interaction between the oral and the intestinal microbiota and how they influence each other and the development of different...