Adele with join the department in August 2027

This study reveals how subtle changes in ligand structure control signaling bias at the immunometabolic receptor GPR84, providing structural details for the rational design of drugs with tailored sign...

Inside cells, DNA is intimately associated with proteins, forming chromatin. The protein constituents of chromatin vary across the tree of life: histones are the principal building blocks of chromatin...

Cryo-EM captures FAT10 activation and transfer from UBA6 to E2 UBE2Z, revealing FAT10 monopolises UBA6. Efficient transfer requires E2 engagement of both FAT10 UBL domains, particularly UBL2, and co-o...

Accelerating scientific discovery is among the most consequential applications of AI, and computational biomolecular simulation stands out as a particularly promising target within this broader effort...

The three-year project builds on research that began during the early months of the COVID-19 pandemic

The new EMBO Members and Associate Members are recognised for their outstanding achievements in the life sciences

SMCHD1 is a key player in X chromosome inactivation in mammals and has been linked to two human disorders. Here, the authors present insight into SMCHD1’s mode of interaction and functionality at its ...

Cannabidiol (CBD), a nonpsychoactive phytocannabinoid from Cannabis sativa, modulates the α7 nicotinic acetylcholine receptor (α7 nAChR), a key tar...

Regulation of X chromosome inactivation in mammals requires precise control of the levels of the non-coding RNA Xist. Almeida et al. describe an autoregulatory mechanism in which nascent Xist transcri...

The two scientists have been selected for outstanding contributions to their fields

Metamorphic HORMA-domain proteins are essential components of meiotic chromosomes required for fertility. Here, the authors show that meiotic HORMADs contain a flexible loop region that is essential f...

Umbrella sampling is a powerful tool to investigate the underlying free-energy landscapes that govern the permeation properties of small molecules through complex lipid bilayers. However, obtaining co...

Chloroplasts import thousands of nucleus-encoded proteins via multiprotein translocons. The authors elucidate the assembly and molecular architecture of the outer-membrane TOC translocon (the import “...

Professor Higgins continues the 430-year-old tradition of delivering free lectures at London’s oldest Higher Education Institution

The text of an open letter sent by ERC President Maria Leptin to ERC panel members, grantees and other stakeholders on 16 April 2026.

A single base pair insertion in the Sox9 enhancer, Enh13, mediates XX female-to-male sex reversal. This subtle non-coding mutation reconfigures transcriptional regulation, enhances Sox9 expression, re...

Does HIV-1 package host proteins that promote infection? Using in virion RNA interactome capture, Garcia-Moreno et al. mapped human proteins bound to the viral genome inside virions. They identified o...

Iselin et al. explore how the type I IFN response regulates RNA-binding activity using RNA-interactome capture and extend the RIC protocol to assess the role of phosphorylation in this process. Focusi...

Abstract. For more than a century, scientists have worked to characterize, understand, and predict the consequences of mutations. For almost as long, scien

Anju Kudhail (Uphoff lab), Amy Roberts (Seiradake lab) and Grant Rowley (Jansen lab) awarded best poster prizes in Postgraduate Poster Symposium

Nature Communications - SLCO2A1 (also known as OATP2A1) is responsible for the transport of eicosanoids, including prostaglandins (PGs), as well as of a subset of nonsteroidal anti-inflammatory...

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An international team of researchers led by the University of Oxford and Oxford University Hospitals NHS Foundation Trust have demonstrated that hospital analysers can be used to identify fake liquid

We review the use of state-of-the-art enhanced sampling techniques in molecular dynamics (MD) simulations. We briefly introduce the principles and practical considerations underlying the application o...

Counteracting ligands stabilize glycine receptor states revealing mechanisms of pentameric ligand-gated channel allostery.

Bacteriocins are toxins deployed by bacteria to kill their competitors. Here, I reflect on my laboratory’s work on protein bacteriocins and their immunity proteins from Gram-negative bacteria. We unco...

The Suffrage Science Awards honour pioneering women in science, with the January 2026 awards focusing on Maths and Computing

Professor Raymond Dwek and colleagues urge renewed investment in host-targeting broad-spectrum antivirals

This method could help protect vaccine effectiveness, particularly in low-resource settings