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Alejandro Burga

@arburga.bsky.social
226 followers 159 following 19 posts

A.d.i.d.a.s. All day I dream about science. Group Leader at IMBA. Genomics & evolution. Peruano.

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Reposted by Alejandro Burga
Maya Voichek @mayavoichek.bsky.social · 24/09/2026
Super excited to share my postdoctoral work at @imbavienna.bsky.social @viennabiocenter.bsky.social - We discovered that some retrotransposons, or "jumping genes" 🧬, are able to spread from cell to cell via a new viral infectivity route. A short thread: 🧵👇 (1/7)
AI-generated illustration of the soma-to-germline transmission of retrotransposons described in our work
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Reposted by Alejandro Burga
The Cecere Laboratory @cecerelab.bsky.social · 22/05/2026
Our latest work is now online in NSMB: maternal yolk carries microRNAs from the intestine to embryos, shaping gene regulation and stress resilience in the next generation. rdcu.be/fj8Er #Epigenetics #microRNA #Inheritance @pasteur.fr @devstempasteur.bsky.social @erc.europa.eu
nature.com
Soma-to-germline miRNA inheritance through yolk promotes stress resilience in progeny - Nature Structural & Molecular Biology
In this study, the authors use the Caenorhabditis elegans model organism to show that maternal microRNAs are delivered from the intestine to embryos by the yolk, where they regulate gene expression an...
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Reposted by Alejandro Burga
Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 22/05/2026
New insights into #fertilization from the @pauligroup.bsky.social & Ikawa labs! In a tour-de-force study, we discovered ✨ SPARK ✨, a conserved sperm fertilization complex that couples sperm-egg binding to membrane fusion. Read on 🧵👇 and check out our preprint for more details! tinyurl.com/34cm4xat
tinyurl.com
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Reposted by Alejandro Burga
Victoria Deneke @vdeneke.bsky.social · 22/05/2026
How do sperm and egg fuse? Surprisingly, we still don’t fully know… Our field has uncovered many pieces of the fertilization puzzle, but not how they fit together. We identify ✨ SPARK ✨ - a conserved sperm complex that couples sperm-egg binding to fusion. tinyurl.com/34cm4xat Read on! 🧵👇
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Alejandro Burga @arburga.bsky.social · 18/05/2026
🧬 New research from the Burga lab! We took a closer look at a rogue selfish protein and caught evolution in the act of turning something old into something radically new 💡 (a.k.a. neofunctionalization) @imbavienna.bsky.social www.biorxiv.org/content/10.6... Curious? Here’s a breakdown:
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Reposted by Alejandro Burga
Manuel Irimia @mirimiam.bsky.social · 20/04/2026
Thrilled to present our comparative study on the evolution of zygotic genome activation (ZGA)!! 🥚🧬 Amazing PhD work of @campobes.bsky.social together with @fedemantica.bsky.social and many collaborators! @melisupf.bsky.social @crg.eu. Thread below 1/15 www.biorxiv.org/content/10.6...
biorxiv.org
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Reposted by Alejandro Burga
Mia Levine @levine-lab.bsky.social · 28/11/2025
How to keep in step when your (protein) partner speeds up… Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection. Congrats to whole team! www.science.org/doi/10.1126/...
science.org
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity
Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...
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Reposted by Alejandro Burga
Österreichische Akademie der Wissenschaften @oeaw.bsky.social · 01/12/2025
Last call! 📢 Don’t miss Brenda Schulman at the upcoming Hans Tuppy Lecture tommorrow, sharing fresh insights into the dynamic regulation of the ubiquitin–proteasome system! @univie.ac.at @mpibiochem.bsky.social www.oeaw.ac.at/detail/veran...
oeaw.ac.at
Visualisierung von Ubiquitin-vermittelter Regulation
Eine enorm vielseitige Möglichkeit Proteine und Membranfunktionen zu regulieren, basiert auf der Vermittlung des kleinen Proteins Ubiquitin. Die Biochemikerin Brenda Schulman stellt die Zusammenhänge ...
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Reposted by Alejandro Burga
Jonathan Pettitt @genotripe.bsky.social · 28/11/2025
C. elegans researchers were early adopters of open science: "The development of common resources and the belief that research findings and mutant strains should be freely shared has propelled worm research to the forefront" www.pnas.org/doi/10.1073/...
pnas.org
From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism | PNAS
Experimental organisms such as the nematode Caenorhabditis elegans are fundamental to biological discovery. The success of C. elegans research has ...
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Reposted by Alejandro Burga
Carlos Ribeiro @ribeirocarlitos.bsky.social · 26/11/2025
Thrilled to share our new paper! With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste. Link @nature.com: www.nature.com/articles/s41...
nature.com
Evolution of taste processing shifts dietary preference - Nature
Calcium imaging of taste neurons and the ventral brain provides insight into evolutionary divergence of food choice in Drosophila species, supporting a role of sensorimotor processing in addition to p...
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Reposted by Alejandro Burga
Polina Tikanova @polinatikanova.bsky.social · 24/11/2025
Happy to share that my PhD project is finally published!🪱✨ Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
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Vienna BioCenter Scientific Training @vbcscitraining.bsky.social · 24/11/2025
The Vienna BioCenter Summer School 2026 call is now open for talented undergrads, it's a great opportunity for students who are interested in graduate study in the life sciences. Georg Busslinger from CeMM is recruiting! Please share training.vbc.ac.at/summer-school
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Reposted by Alejandro Burga
Institute of Molecular Biotechnology @imbavienna.bsky.social · 24/11/2025
🚨 New paper alert! Scientists in the Burga lab show for the first time how toxin-antidote elements—selfish genetic elements that perpetuate by poisoning those embryos that don’t inherit them—evolved from normal cellular proteins. More: imba.science/3M3fRyq
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Alejandro Burga @arburga.bsky.social · 24/11/2025
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
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