Paraschiakos, Yuan et al., using a computational pipeline, identify the short linear actin filament-binding motif (SFM) as an evolutionarily conserved actin filament-binding motif present in 103 human...

Dr. Thomas D. Pollard's work transformed cytoskeleton research into a quantitative, mechanistic science. Over five decades, he established core principles of actin dynamics, including filament polari...

The yeast Candida auris is an emerging health threat. Sopelniak et al. show that uptake of C. auris cells by primary human macrophages involves the formation of phagocytic podosomes, highly dynamic actin structures that enable close adhesion to C. auris cells and are associated with proper maturation of respective phagosomes.

Regulation of the actin cytoskeleton by actin binding proteins (ABPs) is essential for cellular homeostasis, and the mode of actin binding determines the activity of ABPs. Here, we discovered a novel ...

The <em>Journal of Microscopy</em> is the oldest journal dedicated to the science of microscopy, publishing the latest advances in microscopy techniques and novel areas of application.

Scientific Article | Here, we present a protocol to investigate the interaction of primary human monocyte-derived macrophages with a tumor spheroid in a...