Reposted by Christophe Le ClaincheHenry De Belly @henrydebelly.bsky.social · 10/06/2026Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place? 920270
Reposted by Christophe Le ClaincheAlushin Lab @alushinlab.bsky.social · 22/04/2026Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @nature.com : www.nature.com/articles/s41...nature.comMyosin forces remodel F-actin for mechanosensitive protein recognition - NatureStructural studies demonstrate that myosin generates forces that cause structural changes in actin, modulating cooperative binding by α-catenin and thus signal transduction and intercellular communica... 37124
Reposted by Christophe Le ClaincheChristophe Le Clainche @actin-paris-saclay.bsky.social · 10/04/2026Thrilled to have contributed to this chem–bio collaboration @polytechniqueparis.bsky.social @i2bcparissaclay.bsky.social, brilliantly developed by Antoine Gamet and led by Bastien Nay, to develop a molecule controlling cell migration by tuning cytoskeleton with light JACS: doi.org/10.1021/jacs... 1135
Christophe Le Clainche @actin-paris-saclay.bsky.social · 10/04/2026Thrilled to have contributed to this chem–bio collaboration @polytechniqueparis.bsky.social @i2bcparissaclay.bsky.social, brilliantly developed by Antoine Gamet and led by Bastien Nay, to develop a molecule controlling cell migration by tuning cytoskeleton with light JACS: doi.org/10.1021/jacs... 1135
Reposted by Christophe Le ClaincheChristophe Le Clainche @actin-paris-saclay.bsky.social · 06/04/2026I2BC is recruiting group leaders in several disciplines. Don’t miss the chance to launch your team at Paris-Saclay. Information : www.i2bc.paris-saclay.fr/wp-content/u... Applications and enquiries : call2026@i2bc.paris-saclay.fr Deadline: April 22, 2026 0311
Christophe Le Clainche @actin-paris-saclay.bsky.social · 06/04/2026I2BC is recruiting group leaders in several disciplines. Don’t miss the chance to launch your team at Paris-Saclay. Information : www.i2bc.paris-saclay.fr/wp-content/u... Applications and enquiries : call2026@i2bc.paris-saclay.fr Deadline: April 22, 2026 0311
Reposted by Christophe Le ClaincheBiophysical Paris @parisseminar.bsky.social · 23/01/2026aqv-days-2026.sciencesconf.org 031
Reposted by Christophe Le ClaincheInstitut Jacques Monod @ijmonod.bsky.social · 06/01/2026✍️The @bladoux.bsky.social / @rmmege.bsky.social Lab contributed to a new publication 📖 @science.org Advances 📃 Actomyosin-dependent assembly of the mechanosensitive machinery from adherens junctions triggers actin polymerization and organization 🔗 www.science.org/doi/10.1126/... 031
Reposted by Christophe Le ClaincheChristophe Le Clainche @actin-paris-saclay.bsky.social · 02/01/2026New paper out! We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution. Huge congrats to Aurélie Favarin, Rayan Said, & all authors! In Science Advances: www.science.org/doi/10.1126/... #actin #myosin #mechanobiology 36827
Reposted by Christophe Le ClainchePablo J. Sáez @pjsaez.bsky.social · 01/01/2026#HappyNewYear ! Let's start 2026 with a @cellcommlab.bsky.social paper How many branches is OK during #CellMigration? It depends on the #cell: for ex. immune cells are just fine. In collab. w. #NirGov @hfspo.bsky.social Full www.science.org/doi/10.1126/... @focalplane.bsky.social @science.org 🧪🔬 47918
Christophe Le Clainche @actin-paris-saclay.bsky.social · 02/01/2026New paper out! We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution. Huge congrats to Aurélie Favarin, Rayan Said, & all authors! In Science Advances: www.science.org/doi/10.1126/... #actin #myosin #mechanobiology 36827
Reposted by Christophe Le ClaincheVicky Lioy @vslioy.bsky.social · 08/12/2025Open FSEP position in our team 📣 Nous recrutons un/e Ingénieur/e d’étude en biologie. Profil : être titulaire d’un poste permanent au CNRS (IE) et avoir envie d’étudier la chromatine bactérienne 😉 Date limite : jeudi 15 janvier. Détails et candidature ici : mobiliteinterne.cnrs.fr/ords/afip/ow...mobiliteinterne.cnrs.frDétails de la fonction choisie 036
Reposted by Christophe Le ClaincheManuel Thery @manuelthery.bsky.social · 14/10/2025We hire! The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities. More details here: cytomorpholab.com/index.php/jo... 08373
Christophe Le Clainche @actin-paris-saclay.bsky.social · 12/09/2025This week we are celebrating the 10th anniversary of the I2BC — very proud of what we have accomplished together! www.i2bc.paris-saclay.fr 061
Christophe Le Clainche @actin-paris-saclay.bsky.social · 06/08/2025🎓 My team is seeking a PhD student in Biochemistry & Cell Biology at I2BC, Paris-Saclay! 🔬 Study cytoskeletal signaling in collective cell migration 🌍 Fully funded, 3 yrs | 📍 Gif-sur-Yvette, France 🗓️ Apply by Aug 22 via the following link: emploi.cnrs.fr/Offres/Docto... 01315
Reposted by Christophe Le ClaincheKat Toropova @kattoropova.bsky.social · 30/04/2025Postdoc position in my lab: investigating how the microtubule motor protein dynein-2 works in cilia. Here's dynein-2 at work translocating microtubules - how is this activity regulated? How does dynein-2 malfunction in disease? Find out more and apply: my.corehr.com/pls/uoxrecru... 26434
Reposted by Christophe Le ClaincheRobert Arkowitz @robertarkowitz.bsky.social · 05/04/2025Genetically encoded reporters of actin filament organization in living cells and tissues: Cell www.cell.com/cell/fulltex...cell.comGenetically encoded reporters of actin filament organization in living cells and tissuesTailoring genetic fusions of widely used actin localization reporters by constraining the mobility of the fluorescent proteins allows measurements of actin filament organization in living cells and ti... 0288
Reposted by Christophe Le ClaincheFlorence Niedergang @florenceniedergang.bsky.social · 28/03/2025Our latest publication on #macrophages congrats Anna Mularski and @manondepierre.bsky.social @institutcochin.bsky.social @actin-paris-saclay.bsky.social Martial Balland @grenoblealpes.bsky.social @cnrsbiologie.bsky.social cnrs physique @anr 0135
Reposted by Christophe Le ClaincheInstitut Jacques Monod @ijmonod.bsky.social · 24/03/2025✍️ The @bladoux.bsky.social / @rmmege.bsky.social Lab published a new article 📖 Nature materials 📃 Force transmission is a master regulator of mechanical cell competition 🔗 www.nature.com/articles/s41...nature.comForce transmission is a master regulator of mechanical cell competition - Nature MaterialsDifferences in force transmission capabilities between competing cells create large stress fluctuation at their interface, resulting in upward forces and cell elimination, which might have implication... 0113
Reposted by Christophe Le ClaincheBenoit Ladoux @bladoux.bsky.social · 14/03/2025Happy to share our new publication in @naturematerials.bsky.social on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats @luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉 www.nature.com/articles/s41... 16933
Reposted by Christophe Le ClaincheJournal of Cell Biology @jcb.org · 21/03/2025In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/... 35933
Reposted by Christophe Le ClaincheJournal of Cell Biology @jcb.org · 12/02/2025Our new #Mechanobiology collection examines the mechanical properties & interactions that shape the fundamental operations & structures of cells. Delve into diverse mechanical properties of membranes, organelles & other structures within & among cells 👉 buff.ly/3EK0uaq 13411
Christophe Le Clainche @actin-paris-saclay.bsky.social · 15/03/2025Congratulations to all ! Very happy to have been part of this collaboration ! 020
Reposted by Christophe Le ClaincheManuel Thery @manuelthery.bsky.social · 05/03/2025Unique opportunity to join the CytoMorpho Lab (in Paris ❤️) as a postdoc to work on the self-organization and polarization of reconstituted networks made of microtubules, motors and actin filaments in vitro. Experience required. Please Repost 🙏 thanks ! 06277
Christophe Le Clainche @actin-paris-saclay.bsky.social · 24/02/2025Don't miss the opportunity to come and work with us, as this is the last week to apply for our cell biology group leader position. Application deadline: Feb 28, 2025 01716
Reposted by Christophe Le ClaincheSerini Lab @adhynamic.bsky.social · 23/02/2025Glad to share our last manuscript on a luminescent sensor we created to unveil novel potentially actionable regulators of β1 integrin activation in vascular endothelial cells and angiogenesis. @cp-cellreports.bsky.social www.cell.com/cell-reports... 0127
Reposted by Christophe Le Clainchelab-scita.bsky.social @lab-scita.bsky.social · 01/02/2025Deeply saddened by the passing of Prof. Mike Sheetz, a true leader in Mechanobiology. His groundbreaking work on Kinesin, membrane organization, and mechanotransduction has left an indelible mark. A tremendous loss to science. #Mechanobiology #Science #LaskerAward 310733
Christophe Le Clainche @actin-paris-saclay.bsky.social · 27/01/2025The Institute for Integrative Biology of the Cell (I2BC) is recruiting group leaders in cell biology. Don't miss the opportunity to start your team in the vibrant environment of Paris-Saclay University. Application deadline: Feb 28, 2025 www.i2bc.paris-saclay.fr @i2bcparissaclay.bsky.social 03447
Reposted by Christophe Le ClaincheUri Manor @manorlaboratory.bsky.social · 07/01/2025Our collaboration with the Germain Lab is now out in its final form! 65613
Reposted by Christophe Le ClaincheMehmet Can Uçar @mehmetcanucar.bsky.social · 02/12/2024📣 I’m looking for PhD students to work at the intersection of theoretical physics & biology -topics range from active cell mechanics to collective cell migration & tissue patterning! Feel free to reach out for more info (DM/email)! Please repost / share 🙂 12516
Christophe Le Clainche @actin-paris-saclay.bsky.social · 05/12/2024OFFRE D'EMPLOI / JOB OFFER (IN FRENCH) Notre équipe peut accueillir un-e assistant-e ingénieur-e en biologie (déjà en poste au CNRS) dans le cadre du programme NOEMI de mobilité interne du CNRS. Pour candidater et obtenir plus d’informations : bit.ly/4gjpFhQbit.lyDétails de la fonction choisie 0715
Reposted by Christophe Le ClaincheStephane Vassilopoulos @stefvass.bsky.social · 03/12/2024Clathrin-coated pits, plaques, and adhesion... This post is dedicated to Christien Merrifield, who left us far too soon around this time in 2017. His memory continues to inspire 🔬 doi.org/10.1016/j.js... 46313
Reposted by Christophe Le ClaincheCarsten Schulte @carstenschulte4.bsky.social · 21/11/2024I didn't find a specific mechanotransduction starter pack, so I open one myself😊. There are still a lot of people to be added, but it's late, so please drop me a message or post here to nominate yourself for the Mechanotransduction community. go.bsky.app/2PXf5SC 399043
Reposted by Christophe Le ClaincheA. T. Molines @atmolines.bsky.social · 18/11/2024Recently, I joined @actin-paris-saclay.bsky.social team as an Assoc. Prof. 🎉 There I will continue to explore the feedback between the physics of the cytoplasm and cytoskeleton dynamics using in cellulo and in vitro approaches. I am looking forward to interacting with you all here. 231
Reposted by Christophe Le ClaincheOlivier Namy 🧬🧪 @onamy.bsky.social · 17/11/2024go.bsky.app/Kjf7vCa I made this starter pack for #I2BC members. If you are not on the list, sorry. Please contact me I will add you 😉 (corrected) 131410
Christophe Le Clainche @actin-paris-saclay.bsky.social · 16/11/2024Happy to have contributed to Alexis Gautreau's lab article by John James and Stéphane Romero ! Congratulations to all co-authors ! Vinculin–Arp2/3 interaction inhibits branched actin assembly to control migration and proliferation. www.life-science-alliance.org/content/8/2/...life-science-alliance.orgVinculin–Arp2/3 interaction inhibits branched actin assembly to control migration and proliferationVinculin is a mechanotransducer that reinforces links between cell adhesions and linear arrays of actin filaments upon myosin-mediated contractility. Both adhesions to the substratum and neighboring c... 1101
Christophe Le Clainche @actin-paris-saclay.bsky.social · 14/11/2024The Institute for Integrative Biology of the Cell (I2BC) is seeking to recruit new group leaders in cell biology. The application deadline is February 28, 2025 www.i2bc.paris-saclay.fr 26267
Reposted by Christophe Le ClaincheDr. Ahna Skop @ahnaskop.bsky.social · 12/11/2024More cell biologists! #cellbiology go.bsky.app/Utnjx1a 335832
Reposted by Christophe Le ClaincheJohannes Hohlbein @hohlbeinlab.bsky.social · 13/11/2024First attempt in a (loosely defined) Single-Molecule Biophysics starter pack. Please share and (self-) nominate. go.bsky.app/CteFZM5 6510760
Reposted by Christophe Le ClaincheJorge Ferreira @jorgeferreira.bsky.social · 11/11/2024Thought this would be a great opportunity to gather the #mechanobiology community. Please feel free to spread the word. go.bsky.app/G5cQqYT 205232
Reposted by Christophe Le ClaincheBeth Cimini 🔬💻📊 @bethcimini.bsky.social · 06/11/2024Made a starter pack for microscopy and image analysis - please (self-)nominate additions! go.bsky.app/Nwa91pC 6414785
Reposted by Christophe Le ClaincheGuillaume Jacquemet @guijacquemet.bsky.social · 11/11/2024I started a list of people working broadly on cell adhesion and cell migration. I likely missed many, please drop me a message if you want to be added go.bsky.app/5Gzo7oZ 277127
Reposted by Christophe Le ClaincheGal Haimovich ☣ 🧪🔬🎗 @grnfluoresceblg.bsky.social · 11/11/2024here's the starter pack for cytoskeleton go.bsky.app/TF83cpi 264528
Christophe Le Clainche @actin-paris-saclay.bsky.social · 10/11/2024Very pleased to share the publication of our paper "Talin and vinculin combine their activities to trigger actin assembly" in Nature Commun. Congratulations Hong Wang for your great work ! Thanks to our team members, and the Grosse team. Article here: www.nature.com/articles/s41... 1187