Sign in

Christophe Le Clainche

@actin-paris-saclay.bsky.social
2.1K followers 840 following 32 posts

Actin cytoskeleton-associated machines that produce and sense force in adhesion and migration. CNRS researcher, Group leader, Head of Cell Bio dept at www.i2bc.paris-saclay.fr scholar.google.fr/citations?user=tO…

PostsRepliesMedia
Reposted by Christophe Le Clainche
Henry De Belly @henrydebelly.bsky.social · 10/06/2026
Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?
920270
Reposted by Christophe Le Clainche
Alushin Lab @alushinlab.bsky.social · 22/04/2026
Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @nature.com : www.nature.com/articles/s41...
nature.com
Myosin forces remodel F-actin for mechanosensitive protein recognition - Nature
Structural studies demonstrate that myosin generates forces that cause structural changes in actin, modulating cooperative binding by α-catenin and thus signal transduction and intercellular communica...
37124
Reposted by Christophe Le Clainche
Christophe Le Clainche @actin-paris-saclay.bsky.social · 10/04/2026
Thrilled to have contributed to this chem–bio collaboration @polytechniqueparis.bsky.social @i2bcparissaclay.bsky.social, brilliantly developed by Antoine Gamet and led by Bastien Nay, to develop a molecule controlling cell migration by tuning cytoskeleton with light JACS: doi.org/10.1021/jacs...
1135
Christophe Le Clainche @actin-paris-saclay.bsky.social · 10/04/2026
Thrilled to have contributed to this chem–bio collaboration @polytechniqueparis.bsky.social @i2bcparissaclay.bsky.social, brilliantly developed by Antoine Gamet and led by Bastien Nay, to develop a molecule controlling cell migration by tuning cytoskeleton with light JACS: doi.org/10.1021/jacs...
1135
Reposted by Christophe Le Clainche
Christophe Le Clainche @actin-paris-saclay.bsky.social · 06/04/2026
I2BC is recruiting group leaders in several disciplines. Don’t miss the chance to launch your team at Paris-Saclay. Information : www.i2bc.paris-saclay.fr/wp-content/u... Applications and enquiries : call2026@i2bc.paris-saclay.fr Deadline: April 22, 2026
0311
Christophe Le Clainche @actin-paris-saclay.bsky.social · 06/04/2026
I2BC is recruiting group leaders in several disciplines. Don’t miss the chance to launch your team at Paris-Saclay. Information : www.i2bc.paris-saclay.fr/wp-content/u... Applications and enquiries : call2026@i2bc.paris-saclay.fr Deadline: April 22, 2026
0311
Reposted by Christophe Le Clainche
Biophysical Paris @parisseminar.bsky.social · 23/01/2026
aqv-days-2026.sciencesconf.org
031
Reposted by Christophe Le Clainche
Institut Jacques Monod @ijmonod.bsky.social · 06/01/2026
✍️The @bladoux.bsky.social / @rmmege.bsky.social Lab contributed to a new publication 📖 @science.org Advances 📃 Actomyosin-dependent assembly of the mechanosensitive machinery from adherens junctions triggers actin polymerization and organization 🔗 www.science.org/doi/10.1126/...
031
Reposted by Christophe Le Clainche
Christophe Le Clainche @actin-paris-saclay.bsky.social · 02/01/2026
New paper out! We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution. Huge congrats to Aurélie Favarin, Rayan Said, & all authors! In Science Advances: www.science.org/doi/10.1126/... #actin #myosin #mechanobiology
36827
Reposted by Christophe Le Clainche
Pablo J. Sáez @pjsaez.bsky.social · 01/01/2026
#HappyNewYear ! Let's start 2026 with a @cellcommlab.bsky.social paper How many branches is OK during #CellMigration? It depends on the #cell: for ex. immune cells are just fine. In collab. w. #NirGov @hfspo.bsky.social Full www.science.org/doi/10.1126/... @focalplane.bsky.social @science.org 🧪🔬
47918
Christophe Le Clainche @actin-paris-saclay.bsky.social · 02/01/2026
New paper out! We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution. Huge congrats to Aurélie Favarin, Rayan Said, & all authors! In Science Advances: www.science.org/doi/10.1126/... #actin #myosin #mechanobiology
36827
Reposted by Christophe Le Clainche
Vicky Lioy @vslioy.bsky.social · 08/12/2025
Open FSEP position in our team 📣 Nous recrutons un/e Ingénieur/e d’étude en biologie. Profil : être titulaire d’un poste permanent au CNRS (IE) et avoir envie d’étudier la chromatine bactérienne 😉 Date limite : jeudi 15 janvier. Détails et candidature ici : mobiliteinterne.cnrs.fr/ords/afip/ow...
mobiliteinterne.cnrs.fr
Détails de la fonction choisie
036
Reposted by Christophe Le Clainche
Manuel Thery @manuelthery.bsky.social · 14/10/2025
We hire! The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities. More details here: cytomorpholab.com/index.php/jo...
08373
Christophe Le Clainche @actin-paris-saclay.bsky.social · 12/09/2025
This week we are celebrating the 10th anniversary of the I2BC — very proud of what we have accomplished together! www.i2bc.paris-saclay.fr
061
Christophe Le Clainche @actin-paris-saclay.bsky.social · 06/08/2025
🎓 My team is seeking a PhD student in Biochemistry & Cell Biology at I2BC, Paris-Saclay! 🔬 Study cytoskeletal signaling in collective cell migration 🌍 Fully funded, 3 yrs | 📍 Gif-sur-Yvette, France 🗓️ Apply by Aug 22 via the following link: emploi.cnrs.fr/Offres/Docto...
01315
Reposted by Christophe Le Clainche
Kat Toropova @kattoropova.bsky.social · 30/04/2025
Postdoc position in my lab: investigating how the microtubule motor protein dynein-2 works in cilia. Here's dynein-2 at work translocating microtubules - how is this activity regulated? How does dynein-2 malfunction in disease? Find out more and apply: my.corehr.com/pls/uoxrecru...
26434
Reposted by Christophe Le Clainche
Robert Arkowitz @robertarkowitz.bsky.social · 05/04/2025
Genetically encoded reporters of actin filament organization in living cells and tissues: Cell www.cell.com/cell/fulltex...
cell.com
Genetically encoded reporters of actin filament organization in living cells and tissues
Tailoring genetic fusions of widely used actin localization reporters by constraining the mobility of the fluorescent proteins allows measurements of actin filament organization in living cells and ti...
0288
Reposted by Christophe Le Clainche
Florence Niedergang @florenceniedergang.bsky.social · 28/03/2025
Our latest publication on #macrophages congrats Anna Mularski and @manondepierre.bsky.social @institutcochin.bsky.social @actin-paris-saclay.bsky.social Martial Balland @grenoblealpes.bsky.social @cnrsbiologie.bsky.social cnrs physique @anr
0135
Reposted by Christophe Le Clainche
Institut Jacques Monod @ijmonod.bsky.social · 24/03/2025
✍️ The @bladoux.bsky.social / @rmmege.bsky.social Lab published a new article 📖 Nature materials 📃 Force transmission is a master regulator of mechanical cell competition 🔗 www.nature.com/articles/s41...
nature.com
Force transmission is a master regulator of mechanical cell competition - Nature Materials
Differences in force transmission capabilities between competing cells create large stress fluctuation at their interface, resulting in upward forces and cell elimination, which might have implication...
0113
Reposted by Christophe Le Clainche
Benoit Ladoux @bladoux.bsky.social · 14/03/2025
Happy to share our new publication in @naturematerials.bsky.social on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats @luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉 www.nature.com/articles/s41...
16933
Reposted by Christophe Le Clainche
Journal of Cell Biology @jcb.org · 21/03/2025
In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...
35933
Reposted by Christophe Le Clainche
Journal of Cell Biology @jcb.org · 12/02/2025
Our new #Mechanobiology collection examines the mechanical properties & interactions that shape the fundamental operations & structures of cells. Delve into diverse mechanical properties of membranes, organelles & other structures within & among cells 👉 buff.ly/3EK0uaq
13411
Christophe Le Clainche @actin-paris-saclay.bsky.social · 15/03/2025
Congratulations to all ! Very happy to have been part of this collaboration !
020
Reposted by Christophe Le Clainche
Manuel Thery @manuelthery.bsky.social · 05/03/2025
Unique opportunity to join the CytoMorpho Lab (in Paris ❤️) as a postdoc to work on the self-organization and polarization of reconstituted networks made of microtubules, motors and actin filaments in vitro. Experience required. Please Repost 🙏 thanks !
06277
Christophe Le Clainche @actin-paris-saclay.bsky.social · 24/02/2025
Don't miss the opportunity to come and work with us, as this is the last week to apply for our cell biology group leader position. Application deadline: Feb 28, 2025
01716
Reposted by Christophe Le Clainche
Serini Lab @adhynamic.bsky.social · 23/02/2025
Glad to share our last manuscript on a luminescent sensor we created to unveil novel potentially actionable regulators of β1 integrin activation in vascular endothelial cells and angiogenesis. @cp-cellreports.bsky.social www.cell.com/cell-reports...
• β1 integrin activation sensor (β1IAS) reports β1 integrin activation in response to biochemical and physical stimuli

• siRNA HTS on β1IAS KI endothelial cells unveils unknown regulators of β1 integrin activation

• E3 ubiquitin ligase Pja2 promotes kindlin-2 degradation and inhibits β1 integrin activation

• VEGF-B is a so far unrecognized effective inhibitor of β1 integrin activation
0127
Reposted by Christophe Le Clainche
lab-scita.bsky.social @lab-scita.bsky.social · 01/02/2025
Deeply saddened by the passing of Prof. Mike Sheetz, a true leader in Mechanobiology. His groundbreaking work on Kinesin, membrane organization, and mechanotransduction has left an indelible mark. A tremendous loss to science. #Mechanobiology #Science #LaskerAward
310733
Christophe Le Clainche @actin-paris-saclay.bsky.social · 27/01/2025
The Institute for Integrative Biology of the Cell (I2BC) is recruiting group leaders in cell biology. Don't miss the opportunity to start your team in the vibrant environment of Paris-Saclay University. Application deadline: Feb 28, 2025 www.i2bc.paris-saclay.fr @i2bcparissaclay.bsky.social
03447
Reposted by Christophe Le Clainche
Uri Manor @manorlaboratory.bsky.social · 07/01/2025
Our collaboration with the Germain Lab is now out in its final form!
65613
Reposted by Christophe Le Clainche
Mehmet Can Uçar @mehmetcanucar.bsky.social · 02/12/2024
📣 I’m looking for PhD students to work at the intersection of theoretical physics & biology -topics range from active cell mechanics to collective cell migration & tissue patterning! Feel free to reach out for more info (DM/email)! Please repost / share 🙂
PhD positions available at the intersection of theoretical physics & biology (contact: m.c.ucar@sheffield.ac.uk )
12516
Christophe Le Clainche @actin-paris-saclay.bsky.social · 05/12/2024
OFFRE D'EMPLOI / JOB OFFER (IN FRENCH) Notre équipe peut accueillir un-e assistant-e ingénieur-e en biologie (déjà en poste au CNRS) dans le cadre du programme NOEMI de mobilité interne du CNRS. Pour candidater et obtenir plus d’informations : bit.ly/4gjpFhQ
bit.ly
Détails de la fonction choisie
0715
Reposted by Christophe Le Clainche
Stephane Vassilopoulos @stefvass.bsky.social · 03/12/2024
Clathrin-coated pits, plaques, and adhesion... This post is dedicated to Christien Merrifield, who left us far too soon around this time in 2017. His memory continues to inspire 🔬 doi.org/10.1016/j.js...
46313
Reposted by Christophe Le Clainche
Carsten Schulte @carstenschulte4.bsky.social · 21/11/2024
I didn't find a specific mechanotransduction starter pack, so I open one myself😊. There are still a lot of people to be added, but it's late, so please drop me a message or post here to nominate yourself for the Mechanotransduction community. go.bsky.app/2PXf5SC
399043
Reposted by Christophe Le Clainche
A. T. Molines @atmolines.bsky.social · 18/11/2024
Recently, I joined @actin-paris-saclay.bsky.social team as an Assoc. Prof. 🎉 There I will continue to explore the feedback between the physics of the cytoplasm and cytoskeleton dynamics using in cellulo and in vitro approaches. I am looking forward to interacting with you all here.
231
Reposted by Christophe Le Clainche
Olivier Namy 🧬🧪 @onamy.bsky.social · 17/11/2024
go.bsky.app/Kjf7vCa I made this starter pack for #I2BC members. If you are not on the list, sorry. Please contact me I will add you 😉 (corrected)
131410
Christophe Le Clainche @actin-paris-saclay.bsky.social · 16/11/2024
Happy to have contributed to Alexis Gautreau's lab article by John James and Stéphane Romero ! Congratulations to all co-authors ! Vinculin–Arp2/3 interaction inhibits branched actin assembly to control migration and proliferation. www.life-science-alliance.org/content/8/2/...
life-science-alliance.org
Vinculin–Arp2/3 interaction inhibits branched actin assembly to control migration and proliferation
Vinculin is a mechanotransducer that reinforces links between cell adhesions and linear arrays of actin filaments upon myosin-mediated contractility. Both adhesions to the substratum and neighboring c...
1101
Christophe Le Clainche @actin-paris-saclay.bsky.social · 14/11/2024
The Institute for Integrative Biology of the Cell (I2BC) is seeking to recruit new group leaders in cell biology. The application deadline is February 28, 2025 www.i2bc.paris-saclay.fr
26267
Reposted by Christophe Le Clainche
Dr. Ahna Skop @ahnaskop.bsky.social · 12/11/2024
More cell biologists! #cellbiology go.bsky.app/Utnjx1a
335832
Reposted by Christophe Le Clainche
Johannes Hohlbein @hohlbeinlab.bsky.social · 13/11/2024
First attempt in a (loosely defined) Single-Molecule Biophysics starter pack. Please share and (self-) nominate. go.bsky.app/CteFZM5
6510760
Reposted by Christophe Le Clainche
Jorge Ferreira @jorgeferreira.bsky.social · 11/11/2024
Thought this would be a great opportunity to gather the #mechanobiology community. Please feel free to spread the word. go.bsky.app/G5cQqYT
205232
Reposted by Christophe Le Clainche
Beth Cimini 🔬💻📊 @bethcimini.bsky.social · 06/11/2024
Made a starter pack for microscopy and image analysis - please (self-)nominate additions! go.bsky.app/Nwa91pC
6414785
Reposted by Christophe Le Clainche
Guillaume Jacquemet @guijacquemet.bsky.social · 11/11/2024
I started a list of people working broadly on cell adhesion and cell migration. I likely missed many, please drop me a message if you want to be added go.bsky.app/5Gzo7oZ
277127
Reposted by Christophe Le Clainche
Gal Haimovich ☣ 🧪🔬🎗 @grnfluoresceblg.bsky.social · 11/11/2024
here's the starter pack for cytoskeleton go.bsky.app/TF83cpi
264528
Christophe Le Clainche @actin-paris-saclay.bsky.social · 10/11/2024
Very pleased to share the publication of our paper "Talin and vinculin combine their activities to trigger actin assembly" in Nature Commun. Congratulations Hong Wang for your great work ! Thanks to our team members, and the Grosse team. Article here: www.nature.com/articles/s41...
TIRF microscopy of the nucleation of a single actin filament (green) by talin (red) and vinculin (cyan) immobilized on the surface.
1187