iiinova — where your digital self keeps evolving

Reposted by Meghan Morrissey

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 16/12/2025

Congratulations @jcstark.bsky.social and the team, antibody-lectin chimeras (AbLecs), a new modality for cancer immune therapy, now published @natbiotech.nature.com. These bispecifics can block glyco-immune checkpoint receptor ligands directly at the immune synapse/activate immune effector functions

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Reposted by Meghan Morrissey

Journal of Cell Biology @jcb.org · 15/12/2025

Macrophage fireworks 🎆 from Miller et al. of the @mmorrissey.bsky.social lab (doi.org/10.1083/jcb....) showing a #macrophage expressing Vav1-mCherry (magenta) interacting with IgG (yellow) on a supported lipid bilayer containing ICAM-1. More in JCB's December issue: rupress.org/jcb/issue/22...

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Meghan Morrissey @mmorrissey.bsky.social · 17/10/2025

We have TWO papers out in @jcb.org this month! 🎉 First, @kirstin-rollins.bsky.social showed that macrophages nibble adherent target cells, like the ones found in solid tumors, instead of phagocytosing. Amazing movies from @sareenfiaz.bsky.social doi.org/10.1083/jcb....

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Reposted by Meghan Morrissey

Rockefeller University Press @rupress.org · 16/10/2025

In @jcb.org, @mmorrissey.bsky.social lab demonstrate that the CD47 signaling pathway prevents #phagocytosis through dephosphorylation of the Rac GEF Vav. Cancer cells & synthetic targets w/ CD47 can still be phagocytosed less efficiently through a Rho-dependent mechanism rupress.org/jcb/article/...

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Reposted by Meghan Morrissey

Journal of Cell Biology @jcb.org · 16/10/2025

Miller, @mmorrissey.bsky.social et al. demonstrate that the CD47 signaling pathway prevents #phagocytosis through dephosphorylation of the Rac GEF Vav. Cancer cells & synthetic targets with CD47 can still be phagocytosed less efficiently through a Rho-dependent mechanism. rupress.org/jcb/article/...

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Reposted by Meghan Morrissey

Journal of Cell Biology @jcb.org · 03/10/2025

@kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al show that #macrophages attack adherent cells using #trogocytosis instead of #phagocytosis. Reducing adhesion increased phagocytosis. Mitotic cells, which disassemble adhesions, are more vulnerable to phagocytosis rupress.org/jcb/article/...

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Reposted by Meghan Morrissey

Rockefeller University Press @rupress.org · 03/10/2025

#Macrophages are presumed to attack antibody-opsonized #cancer cells by #phagocytosis. In @jcb.org, @kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al find that macrophages attack adherent cells using #trogocytosis, or cell nibbling, instead of phagocytosis. rupress.org/jcb/article/...

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Reposted by Meghan Morrissey

Alison Criss @alisoncrissuva.bsky.social · 28/02/2025

Excited by phagocyte biology? Still making summer conference plans? The Phagocytes GRC has an amazing lineup of invited speakers and many opportunities for talks from submitted abstracts. Apply soon for full consideration! www.grc.org/phagocytes-c...

grc.org

2025 Phagocytes Conference GRC

The 2025 Gordon Research Conference on Phagocytes will be held in Waterville Valley, New Hampshire. Apply today to reserve your spot.

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Meghan Morrissey @mmorrissey.bsky.social · 10/02/2025

Excited to share @kirstin-rollins.bsky.social thesis project! 🥳Why do macrophages sometimes eat a whole cell, and sometimes just nibble off pieces? We found that if the target cell is stuck to a substrate or part of a 3D tissue, the macrophage nibbles instead of phagocytosing the whole cell.

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Reposted by Meghan Morrissey

Sen. Adam Schiff @schiff.senate.gov · 08/02/2025

Trump & Musk are making massive cuts to the National Institutes of Health. I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.

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Meghan Morrissey @mmorrissey.bsky.social · 28/01/2025

Extremely grateful to Damon Runyon for this funding, especially with todays news on NIH grants. See a green macrophage nibbling on a pink cancer cell 👇

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Reposted by Meghan Morrissey

Damon Runyon Cancer Research Foundation @damonrunyon.org · 28/01/2025

@mmorrissey.bsky.social is investigating how immune cells known as macrophages might be induced to “nibble” cancer cells to death through a process called trogocytosis.

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Reposted by Meghan Morrissey

Damon Runyon Cancer Research Foundation @damonrunyon.org · 28/01/2025

Congratulations to the recipients of the 2025 Damon Runyon-Rachleff Innovation Award! Five exceptional scientists received initial grants, and three previous awardees were given Stage 2 support to continue their critical work. Read more: www.damonrunyon.org/news/entries...

damonrunyon.org

Damon Runyon Cancer Research Foundation awards $3.2M to innovative early-career scientists

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Reposted by Meghan Morrissey

Journal of Cell Science @jcellsci.bsky.social · 13/01/2025

@annalisebond.bsky.social and @mmorrissey.bsky.social @ucsantabarbara.bsky.social review the biochemical and biophysical mechanisms that macrophages use to tune phagocytic appetite. journals.biologists.com/jcs/article/...

Cartoon showing that phagocytic receptor availability can be modulated through multiple mechanisms. Receptor availability can be modulated by (A) transcriptional changes affecting receptor expression levels, (B) receptor internalization, which reduces available ligand-binding sites, (C) ectodomain shedding, which can cause sequestration of ligands away from signalling domains, (D) post-translational modifications, such as conformational changes that affect ligand binding affinities, and (E) glycosylation that can affect receptor or ligand accessibility.

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Reposted by Meghan Morrissey

Enfu Hui @enfuhui.bsky.social · 04/01/2025

Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...

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Meghan Morrissey @mmorrissey.bsky.social · 15/12/2024

At #Ascb? Check our Wyatt Millers poster on CD47 today at 1:30 (b696) or his talk Monday at 5:30 p in the immune cell biology subgroup!

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Reposted by Meghan Morrissey

Katelyn Spillane @katelynspillane.bsky.social · 25/11/2024

I'm excited to announce the EMBO Workshop on Immunobiophysics: from fundamental physics to understanding the immune response. April 27-May 2, 2025 in Les Houches, France (hybrid format). Registration/abstract details here: meetings.embo.org/event/25-imm... Register by Monday December 2, 2024!

meetings.embo.org

Immunobiophysics: From fundamental physics to understanding the immune response

Immune cells respond in a coordinated way to protect us from pathogens like viruses and bacteria, and to maintain health by surveying for dysregulated cellular responses as occurs in diseases like ca…

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Reposted by Meghan Morrissey

Natalie Thiex @thiex.bsky.social · 24/11/2024

go.bsky.app/JDAwbAJ Trying again with the actual link this time. Please tag yourself or others who study macropinocytosis, phagocytosis or efferocytosis, and I’ll add you to the pack!

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Meghan Morrissey @mmorrissey.bsky.social · 06/12/2024

Such a great study showing that target biophysics govern the decision to trogocytose (nibble) vs phagocytose

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Reposted by Meghan Morrissey

Fletcher Lab @fletcherlabucb.bsky.social · 05/12/2024

Do you find yourself curious about the eating habits of macrophages? Check out our new preprint to discover the biophysical principles that guide macrophage behavior. www.biorxiv.org/content/10.1...

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Meghan Morrissey @mmorrissey.bsky.social · 12/08/2024

A light appetizer makes macrophages hungrier for their next meal. My lab's first grad student @AnnaliseBond 's first paper is out now in @dev_cell !! authors.elsevier.com/sd/article/S...

authors.elsevier.com

ScienceDirect.com | Science, health and medical journals, full text articles and books.

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Meghan Morrissey @mmorrissey.bsky.social · 23/07/2024

Interested in immune cell biology? Join us for ASCB #cellbio2024 in the subgroup organized by Minna Roh Johnson, Marcus Taylor and me! Just two weeks left to submit your abstract www.ascb.org/cellbio2024/...

ascb.org

Submit an Abstract-Cell Bio 2023

Submit an abstract for Cell Bio 2024-An American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO) Meeting.

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