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Traffic

@traffic-journal.bsky.social
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onlinelibrary.wiley.com/journal/1600... Traffic is a cell biology and biochemistry journal devoted to intracellular transport in health and disease, covering disciplines such as developmental biology, neuroscience, immunology, and infection in eukaryotes.

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Stephane Vassilopoulos @stefvass.bsky.social · 22/09/2026
Great to see this finally out! ✨ A real pleasure to contribute to this special issue celebrating 50 years of #Clathrin and to revisit how this superstar coat keeps surprising us ⚽🔬
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Traffic @traffic-journal.bsky.social · 23/09/2026
congrats @stefvass.bsky.social !!!
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Traffic @traffic-journal.bsky.social · 22/09/2026
Just Published ! #TDP43 #ALS #neurodegeneration #yeast #endoplasmicreticulum onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Investigating Translocation Mechanisms of <fc>TDP</fc>‐43 Into the Endoplasmic Reticulum Using Budding Yeast Models
The graphical abstract illustrates a model in which TDP-43 C-terminal fragments undergo Ste24-suppressed, Sec61/Sec66-dependent noncanonical ER entry in budding yeast. ER entry is facilitated by resi...
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Traffic @traffic-journal.bsky.social · 22/09/2026
Traffic lights just published ! onlinelibrary.wiley.com/doi/10.1111/... #autophagy #neurodegeneration
onlinelibrary.wiley.com
“S‐Tau‐Lled” Lysosomes Disrupt Autophagic Processes in Neurodegeneration
Tauopathies are neurodegenerative diseases characterized by misfolded tau accumulation and lysosomal dysfunction. Pathogenic mutant Tau stalls lysosomes in iPSC-derived neurons upstream of Tau accumu...
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Traffic @traffic-journal.bsky.social · 22/09/2026
Just Published ! #Clathrin superstar! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
From Pits to Plaques: Electron Microscopy Reveals Clathrin Structural Plasticity in Trafficking, Sorting and Adhesion
Clathrin plaques (magenta) form large, flat membrane-associated lattices embedded within the cortical actin cytoskeleton, and can be distinguished from individual clathrin-coated pits (yellow). These....
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Reposted by Traffic
MRC-LMB Cell Biology Division @cellbiol-mrclmb.bsky.social · 28/08/2026
Great tribute to the discovery by Barbara Pearce of clathrin, the first protein found to act in membrane traffic, along with her mentoring and support of the pioneers (many of whom were other women) who revealed the workings of this key player in cellular function.
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Reposted by Traffic
Traffic @traffic-journal.bsky.social · 28/08/2026
Happy 50th anniversary, Clathrin! onlinelibrary.wiley.com/doi/full/10.... @effc.bsky.social
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Traffic @traffic-journal.bsky.social · 28/08/2026
Happy 50th anniversary, Clathrin! onlinelibrary.wiley.com/doi/full/10.... @effc.bsky.social
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Traffic @traffic-journal.bsky.social · 24/08/2026
Just Published ! #{Clathrin 50th anniversary speicla issue @effc.bsky.social onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Functional Specialization of Clathrin‐Independent Endocytic Routes: Mechanisms and Cellular Roles
Distinct clathrin-independent endocytic (CIE) routes support specialized cellular functions across different contexts. Created with Biorender.com.
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Traffic @traffic-journal.bsky.social · 24/08/2026
Just Published ! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Cell Type–Specific Ferroptosis Regulatory Networks in the Bone Microenvironment: Implications for the Pathogenesis and Treatment of Osteoporosis
Overview of ferroptosis in osteoporosis (OP): physiological mechanisms (lysosomal Fe2+ release, mitochondrial ROS, and NINJ1 activation), aging-related systemic amplification and early prevention, bo....
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Reposted by Traffic
Wiley Life Sciences @wileylifesci.bsky.social · 30/07/2026
From new discoveries to emerging research themes. Traffic Lights offers expert commentary on topics driving discussion across cell biology. Read the latest contribution and see what's capturing attention in the field: bit.ly/4c1nNu7 @traffic-journal.bsky.social
Cover of "Traffic" journal by Wiley, featuring a microscopic image of cells with prominent green, blue, and red markers. Text highlights a virtual issue on "Traffic Lights," focusing on discoveries in cell biology research. A "Read It Now" button is displayed at the bottom.
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Traffic @traffic-journal.bsky.social · 17/07/2026
Just Published! onlinelibrary.wiley.com/doi/10.1111/... @labsoap.bsky.social
onlinelibrary.wiley.com
Syntaxin 12 Sustains Endosomal‐Lysosomal Homeostasis and Survival in Glioblastoma Stem‐Like Cells
Syntaxin12 maintains endolysosomal trafficking and lysosomal homeostasis in glioblastoma cells. Syntaxin12 depletion disrupts lysosomal organization, impairs endolysosomal progression and mTOR-lysoso...
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Traffic @traffic-journal.bsky.social · 17/07/2026
Just Published ! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
The Power of Nup85: Controlling Molecular Traffic and Cellular Fate
Nup85 is a protein that plays a critical role in nucleocytoplasmic transport, facilitating the movement of macromolecules, including proteins and RNA, between the nucleus and the cytoplasm. Additiona...
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Traffic @traffic-journal.bsky.social · 23/06/2026
Two more reviews have just been published! #Clathrin is 2026 #Traffic superstar! onlinelibrary.wiley.com/doi/10.1111/... onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Integrating Lateral Super‐Resolution and Axial Progression Reveals Distinct Clathrin Pit Formation Pathways
Variable-angle total internal reflection fluorescence structured illumination microscopy (vaTIRF-SIM) links nanoscale lateral organization with axial progression during clathrin-mediated endocytosis....
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Traffic @traffic-journal.bsky.social · 23/06/2026
#Traffic is proud to inaugurate its #TrafficLights commentary section in a #JournalClub report format... it starts now with @JulieGavard onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Traffic Light Commentary—Src in the Upside Down: A Kinase Turned Inside Out
Just as Antelope Canyon transforms familiar rock into an unexpected hidden landscape, the topological inversion of Src reveals an unforeseen extracellular facet of kinase signaling in cancer. Antelop...
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Traffic @traffic-journal.bsky.social · 16/06/2026
🎉 50 years of #Clathrin! The second article in Traffic's Special Issue is now online. #CellBiology #MembraneTrafficking #Endocytosis #TrafficJournal Edited by Emanuele Cocucci, Jeanne Stachowiak & Margaret Robinson. onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
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Traffic @traffic-journal.bsky.social · 04/05/2026
Just Published ! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
The Lack of a COPII Cargo Receptor Erv14 Impacts Physiological Functions of the Vacuole in Saccharomyces cerevisiae
Loss of the cargo receptor Erv14 in Saccharomyces cerevisiae results in sensitivity to calcium, zinc, neutral extracellular pH, and elevated temperature. Furthermore, cells deleted in the ERV14 exhib...
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Traffic @traffic-journal.bsky.social · 04/05/2026
Just Published ! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
A Toolbox for Quantifying Nuclear and Nucleolar Protein Accumulation Using NLS and NoLS Fusion Reporters
Fluorescent proteins fused with nuclear (NLS) or nucleolar (NoLS) localization signals are commonly used for live assessment of protein accumulation in the nucleus and nucleolus. We present a standar...
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Traffic @traffic-journal.bsky.social · 09/04/2026
Just Published ! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Unraveling the Dynamics of Oxytocin in Hypothalamic Neurons
Oxytocin (OT) plays an important role in regulating social behavior, and dysregulation of the oxytocinergic system leads to social impairments, such as autism spectrum disorder. Central OT release is...
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Traffic @traffic-journal.bsky.social · 30/03/2026
Just Published ! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
KIF5B and Dynein‐Dependent Golgi Organization: Role in Adhesion‐Dependent Microtubule Acetylation
KIF5B and dynein regulate Golgi organization and localization- Role in regulating MT acetylation: In control (CNT) cells, active Arf1 facilitates the recruitment of KIF5B and dynein to the Golgi, mai....
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Traffic @traffic-journal.bsky.social · 16/03/2026
Just Published ! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Protein Kinase D Regulates Kinesin‐Mediated VEGFR2 Trafficking and Influences Retinal Endothelial Permeability
Upon VEGF binding, VEGFR2 is autophosphorylated and recruits downstream signaling molecules, leading to protein kinase D (PKD)1 phosphorylation. We found that PKD1 phosphorylates KIF13B, a kinesin-3 ...
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Traffic @traffic-journal.bsky.social · 12/02/2026
Just Published ! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Palmitoyl Acyltransferases Control the Membrane Localization of DNAJC5 to Regulate Unconventional Protein Secretion
Acylation of DNAJC5 by PAT facilitates its association with the Golgi apparatus, enhancing the secretion of abnormal cytosolic proteins via unconventional protein secretion.
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Traffic @traffic-journal.bsky.social · 05/01/2026
Just Published ! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions
Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule-dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential phys...
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Traffic @traffic-journal.bsky.social · 05/01/2026
Just Published ! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Clathrins Are Involved in the Endocytosis of Host Cytosol in the Malaria Parasite
This study characterized clathrin function in hemoglobin uptake from host red blood cells via the malaria parasite's specific endocytosis machinery, cytostome. Clathrin heavy chain, clathrin light ch...
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Traffic @traffic-journal.bsky.social · 15/12/2025
Just Published !! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Copper Homeostasis at the Crossroads of Cellular Metabolism, Epigenetic Regulation and Protein Trafficking
Copper homeostasis is maintained in the cell by epigenetic regulation, and various metabolic processes. Regulated copper homeostasis balances normal protein trafficking, amino acid metabolism, etc., ...
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Traffic @traffic-journal.bsky.social · 19/11/2025
Just Published ! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
The Role of Small Extracellular Vesicles in Tumor Development and the Prospect of Targeted Therapy
Mechanisms of sEV uptake:① Membrane fusion.② Endocytosis.③ Receptor-ligand interaction.
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Traffic @traffic-journal.bsky.social · 07/11/2025
Just Published ! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Beyond the Secretory Pathway: New Insights Into Protein Release
While proteins bearing N-terminal signal or leader sequences are secreted via the ER-Golgi-plasma membrane axis of the conventional secretion pathway, many cytosolic proteins lacking signaling sequen...
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Traffic @traffic-journal.bsky.social · 23/10/2025
Just Published ! Virion Associated Importin Subunit Beta‐1 Augments Nuclear Import of HIV‐1 Pre‐Integration Complex - Yandrapally - 2025 - Traffic - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
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Traffic @traffic-journal.bsky.social · 23/10/2025
Just Published! Spatiotemporal Analysis of Glucagon Secretory Granule Dynamics - Ghignoli - 2025 - Traffic - Wiley Online Library onlinelibrary.wiley.com/doi/abs/10.1...
onlinelibrary.wiley.com
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Traffic @traffic-journal.bsky.social · 24/09/2025
Just published ! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Strain‐Dependent Immune Signaling by Small Extracellular Vesicles Derived From Trypanosoma cruzi‐Infected Macrophages
Chagas disease, caused by Trypanosoma cruzi, remains a major treatment challenge due to variations in host immunity and parasite strains. We found that small extracellular vesicles (EVs) from infecte...
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Traffic @traffic-journal.bsky.social · 24/09/2025
Just published ! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
From Mechanisms to Therapy: Exploring the Role of Ferroptosis in Cervical Cancer Transformation and Treatment
This review mainly discusses the role of ferroptosis in cervical cancer from four aspects: underlying mechanisms, stage-specific sensitivity, ferroptosis-related targets and biomarkers, and clinical ...
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Traffic @traffic-journal.bsky.social · 03/09/2025
Editor's selected articles of the last two years onlinelibrary.wiley.com/doi/toc/10.1...
onlinelibrary.wiley.com
Editors Choice Articles: Traffic
Traffic is a cell biology and biochemistry journal devoted to intracellular transport, covering subcellular trafficking, membrane dynamics, organelle function & more.
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Reposted by Traffic
Traffic @traffic-journal.bsky.social · 04/03/2025
onlinelibrary.wiley.com/journal/1600... Traffic is a cell biology and biochemistry journal devoted to intracellular transport in health and disease, covering disciplines such as developmental biology, neuroscience, immunology, and infection in eukaryotes.
onlinelibrary.wiley.com
Traffic
Traffic is a cell biology and biochemistry journal devoted to intracellular transport, covering subcellular trafficking, membrane dynamics, organelle function & more.
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Traffic @traffic-journal.bsky.social · 26/08/2025
Just Published ! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
FGF Signaling Promotes Lysosome Biogenesis in Chondrocytes via the Mannose Phosphate Receptor Pathway
FGF signaling regulates lysosomal homeostasis in RCS chondrocytes by inducing TFEB/TFE3 nuclear translocation and activation. This promotes the expression of lysosomal genes and mannose 6-phosphate r....
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Traffic @traffic-journal.bsky.social · 26/08/2025
Just Published! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
CIN85 and CD2AP Are Novel Constituents of Dynamic Tubular Recycling Endosomes That Regulate Recycling Upon Recruitment by MICAL‐L1
In this study, we characterize tubular recycling endosomes and demonstrate that they are dynamic and undergo biogenesis upon CD98 internalization and fission over time. We identify CD2AP and CIN85 as...
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Traffic @traffic-journal.bsky.social · 30/07/2025
Just published! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Eukaryote‐Wide Distribution of a Family of Longin Domain‐Containing GAP Complexes for Small GTPases
The three longin domain-containing GAP complexes - CSW, folliculin, and GATOR1 - have a sporadic but pan-eukaryotic distribution and were likely already present in LECA in some form. Their catalytic ...
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Reposted by Traffic
Institut Jacques Monod @ijmonod.bsky.social · 28/07/2025
✍️ The Jackson/Verbavatz Lab contributed to the publication of a new article 📖 @traffic-journal.bsky.social 📃 Eukaryote-Wide Distribution of a Family of Longin Domain-Containing GAP Complexes for Small GTPases 🔗 onlinelibrary.wiley.com/doi/10.1111/...
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Reposted by Traffic
Eric Chevet @ericchevet.bsky.social · 24/07/2025
@olzmannlab.bsky.social @tgalli.bsky.social @demangelab.bsky.social @agostinislab.bsky.social @abdourachidthiam.bsky.social @molinarilab-er.bsky.social @hennelab.bsky.social @jdejuan-sanz.bsky.social
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Reposted by Traffic
Traffic @traffic-journal.bsky.social · 16/07/2025
Traffic has two calls for papers running: on #clathrin to to celebrate the 50th anniversary of its discovery and #UPS #unconventionalproteinsecretion onlinelibrary.wiley.com/page/journal...
onlinelibrary.wiley.com
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Traffic @traffic-journal.bsky.social · 16/07/2025
Traffic has two calls for papers running: on #clathrin to to celebrate the 50th anniversary of its discovery and #UPS #unconventionalproteinsecretion onlinelibrary.wiley.com/page/journal...
onlinelibrary.wiley.com
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Traffic @traffic-journal.bsky.social · 06/06/2025
Just published onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Salmonella Typhimurium Manipulates Syntaxin 7 to Navigate Endo‐Lysosomal Trafficking in Host Cells
Salmonella Typhimurium hijacks the host Qa-SNARE syntaxin 7 (STX7) to manipulate endo-lysosomal trafficking and sustain intracellular survival. STX7 displays cell–type–specific expression and localis...
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Traffic @traffic-journal.bsky.social · 06/06/2025
Just published onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
TENT5/FAM46: An Enigmatic Family of Secretory Tuners
TENT5s multifaceted roles in key biological processes and human diseases. TENT5 is a family of four proteins (TENT5A–D) with tissue-specific functions influencing tumor proliferation, fertility, bone....
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Traffic @traffic-journal.bsky.social · 06/06/2025
Just published onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
A Sensitive and Versatile Cell‐Based Assay Combines Luminescence and Trapping Approaches to Monitor Unconventional Protein Secretion
In this study, Denus et al. develop a powerful and highly customizable split luciferase-based assay allowing the analysis of multiple cargo proteins released by unconventional protein secretion. This...
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Traffic @traffic-journal.bsky.social · 06/06/2025
Just published onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
BicD and MAP7 Collaborate to Activate Homodimeric Drosophila Kinesin‐1 by Complementary Mechanisms
Kinesin-1 is auto-inhibited and binds microtubules weakly. Binding of kinesin-1 to the adaptor protein BicD enhances processive motion, while the microtubule-associated protein MAP7 recruits more kin....
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Traffic @traffic-journal.bsky.social · 06/06/2025
Just published onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells
Epithelial-immune cell crosstalk is tightly regulated by secretion of immune cell mediators into luminal and serosal fluid spaces of epithelial tissues. We report two major new findings regarding how...
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Traffic @traffic-journal.bsky.social · 02/05/2025
Just Published: Golgi Localized Arl15 Regulates Cargo Transport and Cell Adhesion Prerna Sharma, Pooja Hoovina Venkatesh, Shalini Samal, Neha Paddillaya, Nikita Shah, B. R. Rajeshwari, Abhay Bhat, Deepak Kumar Nayak, Archishman Dakua, Aravind Penmatsa … doi.org/10.1111/tra....
doi.org
Golgi Localized Arl15 Regulates Cargo Transport and Cell Adhesion
The model illustrates the function of Arl15 in vesicular transport and cell surface organization. Arl15 localizes majorly to the Golgi and plasma membrane (PM), which is primarily dependent on Arf1-d...
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Traffic @traffic-journal.bsky.social · 02/05/2025
Just Published: Re-Visiting the Intracellular Pathway of Transferrin on Board of a Mathematical Simulation Franco Nieto, Luis S. Mayorga doi.org/10.1111/tra....
doi.org
Re‐Visiting the Intracellular Pathway of Transferrin on Board of a Mathematical Simulation
The transport of transferrin is among the most extensively studied trafficking processes. In this commentary, we utilize a mathematical simulation of the endomembrane system to revisit transferrin tr...
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Traffic @traffic-journal.bsky.social · 02/05/2025
Just Published: Golgi Localized Arl15 Regulates Cargo Transport and Cell Adhesion Prerna Sharma, Pooja Hoovina Venkatesh, Shalini Samal, Neha Paddillaya, Nikita Shah, B. R. Rajeshwari, Abhay Bhat, Deepak Kumar Nayak, Archishman Dakua, Aravind Penmatsa … See all authors doi.org/10.1111/tra....
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Traffic @traffic-journal.bsky.social · 27/03/2025
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Traffic @traffic-journal.bsky.social · 19/03/2025
just published onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com
Acute GARP Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and O‐Glycosylation
Cartoon illustrating defects caused by GARP dysfunction. (Left) Control cells exhibit normal Golgi morphology with a stratified distribution of enzymes and trafficking machinery. (Right) Following ac...
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