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Camille Keck

@camimille.bsky.social
271 followers 321 following 9 posts

Post Doc at Enninga Lab - Institut Pasteur Paris | cryo electron tomography & Mtb 🧫🔬

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Reposted by Camille Keck
Ricardo D. Righetto @lifeonthewedge.bsky.social · 08/09/2026
A wild publishing ride to get here... but finally! (first bioRxiv: January 5th, 2024 🙃) Amazing work from @lorenzlamm.bsky.social and colleagues 🤗 Special thanks to the community who jumped early on the boat, sharing feedback and training data to make MemBrain v2 a reality 🙏🏽
nature.com
MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomography - Nature Methods
MemBrain v2 enables streamlined analysis of membranes in cryo-electron tomography by providing user-friendly tools for membrane segmentation, membrane protein localization and spatial analysis, suppor...
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Tanmay Bharat @tbharat-lab.bsky.social · 23/08/2026
Molecular architecture of colossal surface layers from hyperthermophilic archaea Led by @idocaspy.bsky.social (Ido) In collaboration with @mkrupovic.bsky.social and @vikramalva.bsky.social labs doi.org/10.64898/202...
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Tobias Warnecke @tobiaswarnecke.bsky.social · 29/07/2026
Bacteriocins in archaea and archaeocins in bacteria. @romainstrock.bsky.social surveys the the exchange of molecular weaponry between archaea and bacteria. www.biorxiv.org/content/10.6...
biorxiv.org
Bacteriocins in archaea and archaeocins in bacteria
Archaea and bacteria routinely live side by side in microbial communities and must interact at least on occasion. Whether such cross-Domain interactions are dominated by mutual disregard, co-operation...
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Nature Plants @natplants.nature.com · 28/07/2026
New OA Article: "Chloroplast-encoded small subunit extensions reshape the Chlamydomonas chlororibosome" rdcu.be/fwoSj In situ cryo-electron tomography reveals a unique ‘arm’ domain on the small subunit of Chlamydomonas chlororibosomes. #PlantScience
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Camila Valenzuela, PhD @kamovalenz.bsky.social · 28/07/2026
I just got some GREAT news: my ANR JCJC proposal was funded!! This is my first big grant, and it will allow me to work on my independent research line to understand the intracellular lifestyles of Salmonella iNTS in epithelial cells
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Paula Navarro @navarropaula.bsky.social · 03/07/2026
🚨 New in @natmicrobiol.nature.com! We reveal how the antibiotic target PBP1b fortifies the E.coli division site against osmotic rupture. Proud this was completed in our independent labs @dmf-unil.bsky.social, with @avettiger.bsky.social. Congratulations to all authors! 🦠❄️🔬 #teamtomo bit.ly/3SCbOg1 👇
doi.org
The penicillin-binding protein PBP1b fortifies the Escherichia coli division site against osmotic rupture - Nature Microbiology
A specific isoform of PBP1b functions independently of the activator protein, LpoB, to drive generation of a wedge-like peptidoglycan structure that strengthens the division site in Escherichia coli.
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Allegretti Lab @matteoall.bsky.social · 27/05/2026
We're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇
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Dimitry Tegunov @dtegunov.bsky.social · 03/05/2026
We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:
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Ben Engel @cellarchlab.com · 14/04/2026
Across scales from cells🦠 to atoms⚛️ – We reveal how anaerobic #bacteria break down very stable aromatic compounds found e.g. in oil spills 🛢️ #Bioremediation #TeamTomo 🧪 🧶🧬 🔬 Awesome collab with Lena, Matthias, @schullerjm.bsky.social @rnfr2d2.bsky.social @tomaspascoa.bsky.social @tamb-o.bsky.social
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Institut Pasteur | 130 years of biomedical research @pasteur.fr · 23/03/2026
🧬 EMBO Workshop – The complexity of mycobacterial infections: from research to real-world impact 📅 14–18 Sept 2026, Paris Tuberculosis & non-tuberculous mycobacteria at the heart of discussions: evolution, host–pathogen interactions, drug resistance. 🔗 meetings.embo.org/event/26-myc...
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains one of the deadliest infectious diseases worldwide. Meanwhile, non-tuberculous mycobacteria (NTM) are an increasing global health concern. NTM infections often resemble TB clinically, which can lead to misdiagnosis and inappropriate therapy. Additionally, drug-resistant strains of M. tuberculosis and NTM exacerbate the global antimicrobial resistance crisis. A better understanding of the biology of mycobacterial pathogens and of the mechanisms underlying disease pathogenesis and transmission is critical to reduce their burden worldwide.

This EMBO Workshop is the fourth in a successful series held at the Institut Pasteur in Paris, following the meetings organized in 2012, 2016, and 2022. It will bring together scientists, clinicians, public health experts, and representatives from industry and non-profit organizations, who will share recent insights into mycobacterial infections, from fundamental discoveries to translational research, and their practical implications. The program will cover mycobacterial evolution, physiology, metabolism, host–pathogen interactions, immune responses, mechanisms of drug evasion, therapeutic strategies, vaccines, and diagnostics. Emerging experimental models, computational approaches, and artificial intelligence will also be addressed, showing how recent technologies contribute to advancing mycobacterial research and interventions.
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Jean-Yves Tinevez @jytinevez.bsky.social · 09/03/2026
Let's get ready for a full month of training in image analysis in @pasteur.fr , this summer! Are you interested in learning how to do bioimage analysis? For light microscopy? for cryo-EM? And for cellular cryo-EM? Stay tuned, Pasteur offers access to THREE courses, this June. 👇🎓
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Ricardo D. Righetto @lifeonthewedge.bsky.social · 05/11/2025
I'm pleased to announce 🍦 Icecream 🍨 v0.3! New features include: * Training on multiple tomograms (same training time, with linear increase in RAM) 🚀 * Logging and plotting of the loss function 📉 * The --scale option is now called --eq-weight for clarity 😉 We'd love to hear your feedback! 🙏🏽
github.com
GitHub - swing-research/icecream: 🍦Icecream: a self-supervised framework for cryo-ET reconstruction
🍦Icecream: a self-supervised framework for cryo-ET reconstruction - swing-research/icecream
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Journal of Cell Biology @jcb.org · 04/11/2025
Glushkova, Böhm, & Beck @maxplanck.de develop a publicly available computational method to measure the thickness of biological membranes in cryo-electron tomograms. Analysis of algae & human cells reveals systematic membrane thickness variations within & across organelles rupress.org/jcb/article/...
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Fusion Conferences @fusionconf.bsky.social · 16/10/2025
We’re excited to announce the incredible speaker line-up for the Prokaryotic Cell Biology Conference! Join the leading researchers as they explore the latest advances in Nanoimaging, Cell Growth and Cellular Structures. Join our speakers & register today! ➡️https://bit.ly/47rtkbw #ProkaryoticCellBio
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Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · 08/10/2025
🧐Checkout our preprint revealing the stepwise firing💥 mechanism of a Contractile Injection System @xujwet.bsky.social&@chipericson.bsky.social trapped the complex by structure-guided engineering🧪 in multiple intermediate states and imaged them by multimodal #cryoEM❄️🔬 www.biorxiv.org/content/10.1...
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Ian Marshall @ianpgm.bsky.social · 08/10/2025
I'm recruiting a postdoc to figure out how aerobic methanotrophic bacteria oxidise methane in anoxic freshwater sediment environments: international.au.dk/about/profil... Come to Aarhus University in Denmark and work on this 2-year project funded by @villumfonden.bsky.social!
international.au.dk
Postdoctoral position on methanotrophic bacteria - Vacancy at Aarhus University
Vacancy at Department of Biology - Microbiology, Aarhus University
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Kenneth Ehses @denkenny.bsky.social · 08/10/2025
✨Excited that the main project of my PhD is now available as a pre-print on #bioRxiv Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo 🔗 www.biorxiv.org/content/10.1...
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Jakob Meier-Credo @meiercredo.bsky.social · 19/09/2025
Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids. Link: www.biorxiv.org/content/10.1...
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Thibaut Brunet @thibautbrunet.bsky.social · 05/10/2025
Latest from ours: www.cell.com/cell-reports... This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
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cryoEM papers @cryoempapers.bsky.social · 01/10/2025
Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1 pubmed.ncbi.nlm.nih.gov/41027961/ #cryoEM
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Ben Engel @cellarchlab.com · 30/09/2025
EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬 The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩‍🔬🤓
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Cascales Lab @cascaleslab.bsky.social · 28/09/2025
We will have soon an Open position for a PhD thesis position to work on bacterial secretion systems ! Stay tuned !!
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Géraldine Laloux @lalouxlab.bsky.social · 17/09/2025
🚨New paper out! #MicroSky Studying obligate predators like Bdellovibrio bacteriovorus is tricky—essential genes for predation are also essential for survival. We expanded its genetic toolbox: 🧬promoters to fine-tune expression 🧬IPTG-inducible system 🧬CRISPRi for rapid knockdown bit.ly/46GUn2c 1/4
academic.oup.com
Expanding the genetic toolbox of the obligate predatory bacterium Bdellovibrio bacteriovorus with inducible gene expression and CRISPR interference
Inducible gene expression and CRISPR interference-mediated depletion in the predatory bacterium Bdellovibrio bacteriovorus.
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Jeunes microbiologistes de la SFM @jm-sfm.bsky.social · 24/09/2025
Cyril Anjou, 2e candidat au prix de thèse nous a présenté ses travaux sur les rôles physiologiques des systèmes thioredoxine de Clostridioides difficile, impliqués dans les étapes du cycle de vie de la bactérie, ainsi que sur l’intérêt thérapeutique potentiel de la modulation de leur expression.🦠
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Olivier Neyrolles @oneyrolles.bsky.social · 23/09/2025
Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org! It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance. Huge congrats to Wendy & colleagues! shorturl.at/WbFQC
pnas.org
Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance | PNAS
Tuberculosis remains the deadliest infectious disease caused by a single pathogen, highlighting the urgent need for novel therapies. A deeper under...
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Enninga Lab @enningalab.bsky.social · 22/09/2025
Time for some insights into our latest #preprint Using cryo–electron tomography, we peeked inside different #Mtuberculosis strains, and a couple of other mycobacteria.🧐 Surprise: some species, especially the host-adapted ones, build intracytoplasmic membranes (we call them MIMs)! 🦠
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Anthony Vecchiarelli @cellforganized.bsky.social · 23/09/2025
New PrePrint from the Vecchiarelli and Mosalaganti (@shyamalm.bsky.social) labs! 🧵 Collaboration with the Giessen and Pi labs Congratulations to co-first authors Y Hoang (@hoanghamyy.bsky.social) and Pankaj Jadhav! www.biorxiv.org/content/10.1...
biorxiv.org
Engineering Spatial Control of Bacterial Organelles
Bacteria were once thought to lack organelles, but it is now clear they confine cellular reactions using an array of membrane- and protein-based compartments. A central question, however, is how bacte...
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eLife @elife.bsky.social · 20/09/2025
🌱 Using ‘compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture. buff.ly/j3TSIkn
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Ben Engel @cellarchlab.com · 20/09/2025
A molecular-resolution look into the near-native architecture of the spinach chloroplast🌱. This one was a long time in the oven, but we're happy to finally share our "version of record". What long-standing debates did we settle? Check back for a short thread🧵 on Monday. #TeamTomo #PlantScience 🧪🧶🧬🔬🌾
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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 19/09/2025
Mycobacterium tuberculosis forms nitrate-induced intracytoplasmic membranes (MIMs) that rewire metabolism & dampen inflammation during infection, uncovering a new layer of bacterial adaptation! ✍️ @camimille.bsky.social @enningalab.bsky.social @pasteur.fr 📖 shorturl.at/9kbDM
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Arthur Lensen @arthurlensen.bsky.social · 18/09/2025
After years of hard work and months of growing MTB @camimille.bsky.social submitted her story ! Check this out if you wanna discover new intrabacterial structures and their function ! 🦠🔬✨
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Julie Le Bris @julielebris.bsky.social · 10/09/2025
How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes? That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus. The paper: www.biorxiv.org/content/10.1... Thread👇
biorxiv.org
Serotype swapping in Klebsiella spp. by plug-and-play
Understanding how complex, multi-gene systems evolve and function across genetic backgrounds is a central question in molecular evolution. While such systems often impose costs through epistatic inter...
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Julie Le Bris @julielebris.bsky.social · 05/09/2025
Delighted to share our recently published work! Ever wondered how Klebsiella (and others) deals with capsule production’s costs ? The paper: journals.asm.org/doi/10.1128/... Thread👇
journals.asm.org
Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio
The polysaccharidic capsule is present in ~50% of species across the bacterial phylogeny, including all ESKAPE microorganisms, the six most significant multidrug-resistant (MDR) nosocomial pathogens. It is also an important virulence factor and a major ...
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Enninga Lab @enningalab.bsky.social · 18/09/2025
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫 Thread coming soon!
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Camila Valenzuela, PhD @kamovalenz.bsky.social · 18/09/2025
New preprint from the lab! Great work led by @camimille.bsky.social #mycobacterium #TB #cryoET
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Sonja-Verena Albers @archaellum.bsky.social · 17/09/2025
Happy to share that our story on the bacterial archaellum was published today in @natmicrobiol.nature.com www.nature.com/articles/s41... Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social
nature.com
Structure of a functional archaellum in Bacteria of the Chloroflexota phylum - Nature Microbiology
Bona fide gene clusters for archaella are widespread across a bacterial phylum and encode functional motility machinery.
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Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · 10/09/2025
Story on our Asgard microtubule paper by Nikki Greenwood: www.quantamagazine.org/tiny-tubes-r... Thanks to all interviewees🎤
quantamagazine.org
Tiny Tubes Reveal Clues to the Evolution of Complex Life | Quanta Magazine
Scientists have identified tubulin structures in primitive Asgard archea that may have been the precursor of our own cellular skeletons.
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 14/09/2025
Peptidoglycan turnover promotes active transport of protein through the bacterial cell wall www.biorxiv.org/content/10.1101/202…
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Phill Stansfeld @pstansfeld.bsky.social · 07/07/2025
New paper out, with a contribution from Dom Gurvic and I; led by Andy Lovering and @lalouxlab.bsky.social: www.nature.com/articles/s41...
nature.com
A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily
Nature Communications - This study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows...
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cryoEM papers @cryoempapers.bsky.social · 10/09/2025
Genetically encoded FerriTag as a specific label for cryo-electron tomography pubmed.ncbi.nlm.nih.gov/40925364/ #cryoEM
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Sven Klumpe @svenklumpe.bsky.social · 15/08/2025
Extremely excited for the second version of this workshop at the MPI of Biophysics l, Frankfurt, that will happen 12-20. April 2026. Absolutely amazing lineup of speakers, I am very much looking forward to learning from everyone! Apply here: meetings.embo.org/event/26-in-...
meetings.embo.org
In situ structural biology by Cryo-FIB and Cryo-ET
Cryo-focused ion beam/scanning electron microscopy (cryo-FIB/SEM) and cryo-electron tomography (cryo-ET) are emerging, versatile tools for structural cell biologists, aiming at the exploration of mol…
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Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · 12/08/2025
Check out 🧐 our new preprint 📜: www.biorxiv.org/content/10.1... Congrats🎉 to @vasilgaisin.bsky.social and Corina Hadjicharalambous, who studied contractile injection systems directly in hot spring♨️ bacterial mats🦠 #microsky #teamtomo #Chloroflexota
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 28/07/2025
Tn7 family bacterial transposons known for tightly controlled target site selection are distributed across Asgard and archaeal groups www.biorxiv.org/content/10.1101/202…
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Typas Lab @typaslab.bsky.social · 30/07/2025
Ready to lead pioneering research that bridges systems-level investigations of biological systems to molecular mechanism? The EMBL Molecular Systems Biology Unit in Heidelberg is hiring a Group Leader!
embl.wd103.myworkdayjobs.com
Group Leader – Molecular Systems Biology Unit
Are you ready to lead groundbreaking research in Molecular Systems Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group, addressing original biological ...
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Institut Pasteur Education @pasteuredu.bsky.social · 25/07/2025
🚨 Only 6 days left to apply! Cryo-Electronic Microscopy – Pasteur Course Master cryo-EM fundamentals through a fully hands-on, 2-week training at the Institut Pasteur. 📅 September 29 – October 10, 2025 🗣️ Course in English ⌛ Application deadline: July 31, 2025 👉 bit.ly/4o1KD9H @pasteur.fr
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Camille Keck @camimille.bsky.social · 02/07/2025
my little zebra friends
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Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · 02/07/2025
Excited and honored to be joining the EMBO Member community 🥳 Congratulations also to all the other newly elected members! -Martin
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Léa Swistak @leaswistak.bsky.social · 26/05/2025
Diving “Google earth mode 🌍” in a Shigella infected cell 🔬🔎 Together with @m-albert.bsky.social
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Alex Crits-Christoph @acritschristoph.bsky.social · 29/06/2025
Cool result: Transposon insertion sequencing reveals novel hypermutator genes in Acinetobacter baumannii "Exposure of a transposon insertion mutant library to extended weak antibiotic selection ... revealed genes that indirectly increased fitness due to elevated general mutation rates"
journals.asm.org
Transposon insertion sequencing reveals novel hypermutator genes in Acinetobacter baumannii | mBio
All organisms have the capacity for evolution through mutation. Bacteria with high mutation rates have a survival advantage in some stressful environments because they generate beneficial mutations mo...
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Josh Dickerson @joshdcryoem.bsky.social · 28/06/2025
Check out our recent review discussing the merits of tilt series vs single micrographs for in situ cryo-EM! www.sciencedirect.com/science/arti...
sciencedirect.com
To tilt or not to tilt? Strategies for in situ cryo-EM data collection
Recent breakthroughs in single-particle cryogenic electron microscopy (cryo-EM) and protein structure prediction have transformed our ability to resol…
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