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Schuller Jan

@schullerjm.bsky.social
277 followers 158 following 56 posts
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Reposted by Schuller Jan
Rhys Grinter @rhyswg.bsky.social · 18/08/2026
Out now in @natmicrobiol.nature.com: Bacillus subtilis builds protein filaments that act as a pseudomembrane, pulling quinone out of the bilayer and carrying it into the cytosol for reduction by NADH dehydrogenase, well away from the membrane itself. doi.org/10.1038/s415... 1/5
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Francis O'Reilly @fjoreilly.bsky.social · 14/08/2026
PhIX-MS is out in Molecular Cell! Rapid in situ photo-crosslinking traps transient proteasome interactions before purification; crosslinking MS, cryo-EM and AlphaFold tell us where they bind. Paper: doi.org/10.1016/j.mo... Preview: doi.org/10.1016/j.mo...
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Florent Waltz @florentwaltz.bsky.social · 07/08/2026
We've been seeing a lot of "in situ" lately in titles from fancy journals (not pointing any fingers 👀). I’ve delayed posting this, but as more and more come out, I'm afraid "in situ" is becoming an empty buzzword, much like "near-atomic" was for SPA 🔬 1/n #cryo-ET #cryo-EM #cryoET #cryoEM 🧪
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Schuller Jan @schullerjm.bsky.social · 21/07/2026
We currently have an opening for a PhD position in the lab. If you are interested in pursuing some serious structural biology of photosynthetic and chloroplast processes please apply. Prerequisite is previous experience in cryoEM and/or phototrophs. stellenangebote.uni-marburg.de/jobposting/2...
stellenangebote.uni-marburg.de
Doctoral and Postdoctoral Researcher Positions in the Cluster of Excellence ‘Microbes for Climate’
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Reposted by Schuller Jan
Laborjournal @laborjournal.bsky.social · 20/07/2026
Das größte bekannte #Enzym? Ein Team um @sophia-pa.bsky.social und @schullerjm.bsky.social vom @synmikro.bsky.social hat einen überzeugenden Kandidaten: einen katalytisch aktiven 8 MDa-Superkomplex aus einem Methan-produzierenden Archaeon … Mehr dazu: 👉https://www.laborjournal.de/editorials/3533.php
3D-Modell des Heterodisulfid-Reduktase-Superkomplexes aus dem Archaeon Methanococcus maripaludis sowie Porträts von Studienleiter Jan Schuller und Erstautorin Sophia Paul. (Fotos: Uni Marburg, Sandra Schuller)
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Gregor Weiss @weiss-lab.bsky.social · 10/07/2026
Some bacteria do not live as individuals. They build multicellular filaments and connect neighboring cells through tiny cell-cell junctions. Cyanobacteria are among the most beautiful examples 😍 In our new paper, we reveal first molecuar insights on the cyanobacterial septal junction architecture 🧵
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Roland Hatzenpichler @environmicrobio.bsky.social · 09/07/2026
Awesome work to determine the structure of a freakin 8MDa enzyme complex with over 600 FeS clusters! Sophia won the poster prize at the recent GRC C1 👏 www.nature.com/articles/s41...
nature.com
Architecture of the 8 MDa Hdr–Vhu–Fwd super-assembly in class I methanogens - Nature
The structure of the Hdr–Vhu–Fwd super-assembly reveals a lineage-specific and modular 8 MDa complex with the ability to adapt to diverse anaerobic niches.
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ProLOEWE @proloewe.bsky.social · 09/07/2026
Huge discovery from Marburg: Prof. Schuller (@synmikro.bsky.social),doctoral stud. @sophia-pa.bsky.social+colleagues have resolved1️⃣of the🧬🔬largest enzymes. Published in Nature, the study shows how methanogenic archaea generate energy under extreme conditions, offering🆕insights into the🌎carbon cycle.
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Sophia Paul @sophia-pa.bsky.social · 08/07/2026
Excited to share my paper! 🥳 Today in #Nature we reveal an 8 MDa Hdr electron bifurcating super-assembly in class I methanogens that couples the first and last steps of hydrogenotrophic methanogenesis. A lineage-specific adaptation to anaerobic niches. www.nature.com/articles/s41...
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Schuller Jan @schullerjm.bsky.social · 08/07/2026
New preprint No7 - molecular architecture of the carbonyl branch enzyme in methanogens. Basically all enzymes of the pathway linked in a super assembly (2 MDa). One would expect a cryoEM study, but we miserably failed, so we used true integrative structural biology. www.biorxiv.org/cgi/content/...
biorxiv.org
Interface swapping orchestrates carbon transfer in the archaeal acetyl-CoA decarbonylase/synthase
The Wood-Ljungdahl pathway is one of biology's most ancient routes for carbon fixation and energy metabolism, used by organisms such as methanogenic archaea. One of its central metabolic complexes is ...
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Schuller Jan @schullerjm.bsky.social · 07/07/2026
Okay the lab is now really living preprints to accelerate Science. It takes so long to publish a story in journals. So the only option to talk openly about our work are preprints. We currently have 6 preprints - check them out! More coming, one currently uploading and another one ready soon.
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Sven T. Stripp @stripplab.bsky.social · 06/07/2026
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trisre.bsky.social @trisre.bsky.social · 06/07/2026
1/ Happy to share our preprint! The Mtr complex catalyses the second-to-last step of the methanogenesis and is an essential bioenergetic machine in most methanogenic archaea. Anaerobic cryo-EM of Mtr reveals a nitrogenase-like metallocluster bound at its active site! www.biorxiv.org/content/10.6...
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Ben Engel @cellarchlab.com · 03/07/2026
Super excited to launch this search for a new endowed professor at the @biozentrum.unibas.ch! Join us to build a research cluster in Climate Biophysics! 🌍🌊🌾🔬🧪 This is a unique opportunity to create a community in Basel🇨🇭working together on this timely topic! ⏳🌡️ Questions? Please reach out! 👩‍🔬👨‍🔬
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Ricardo D. Righetto @lifeonthewedge.bsky.social · 15/04/2026
Crazy biochemistry is the norm for @schullerjm.bsky.social, but here I wanna say I have witnessed up close the amazing effort from @tomaspascoa.bsky.social and @tamb-o.bsky.social to chase the BCRII complex in situ 🤩 Big congrats to Lena Appel and @rnfr2d2.bsky.social for the cryoEM structure too 👏🏽
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Ben Engel @cellarchlab.com · 14/04/2026
Across scales from cells🦠 to atoms⚛️ – We reveal how anaerobic #bacteria break down very stable aromatic compounds found e.g. in oil spills 🛢️ #Bioremediation #TeamTomo 🧪 🧶🧬 🔬 Awesome collab with Lena, Matthias, @schullerjm.bsky.social @rnfr2d2.bsky.social @tomaspascoa.bsky.social @tamb-o.bsky.social
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Ben Engel @cellarchlab.com · 14/04/2026
Thanks for the fun collaboration into this fascinating “oil eating” biomachine. I learned a lot! 🧪 #TeamTomo
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James Lingford @jameslingford.bsky.social · 15/04/2026
Amazing paper. A megadalton enzyme complex that: - combines both electron bifurcation AND confurcation steps - has a new type of iron-sulfur cluster - a new kind of weird electron transfer path - super charges electrons to reduce aromatic rings - also powers respiration 😳
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Anuj @rnfr2d2.bsky.social · 14/04/2026
How do “LEGO-like” electron-bifurcating modules combine to drive degradation in BTEX-contaminated ecosystems? Check out our latest preprint, where we use cryo-EM and cryo-ET to reveal how the 1 MDa BCRII complex powers extremely endergonic aromatic ring reduction. www.biorxiv.org/content/10.6...
biorxiv.org
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Schuller Jan @schullerjm.bsky.social · 14/04/2026
Happy to present our latest story: the BCRII complex with the Boll and @cellarchlab.com . Months of processing by @rnfr2d2.bsky.social. Also @tomaspascoa.bsky.social and @tamb-o.bsky.social managed an in-situ tour de force. And Lena Appel did amazing biochemistry. This story has it all. Enjoy it.
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Tomas Pascoa @tomaspascoa.bsky.social · 14/04/2026
1/ Excited to share our preprint! 🥳 Degradation of aromatic compounds, including BTEX pollutants, requires highly endergonic aromatic ring reduction. Using #cryoEM and in situ #cryoET, we show how BCRII couples electron bifurcation modules in one giant redox machine www.biorxiv.org/content/10.6...
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georghochberg.bsky.social @georghochberg.bsky.social · 04/04/2026
I will probably be hiring either a PhD or a Postdoc in the near future. If you are interested in deep biochemical history or molecular mechanisms of evolution please get in touch.
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Schuller Jan @schullerjm.bsky.social · 28/03/2026
Congratulations 🎉 Anuj. This is well earned and I am a proud supervisor. There is much more coming. @rnfr2d2.bsky.social will present a paradigm shifting story this year at the GRC C1 and EBEC.
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Sven T. Stripp @stripplab.bsky.social · 24/03/2026
Carbonic anhydrase catalyses the interconversion of CO2 and HCO3- and helps increasing the net-CO2 concentration inside cells. Why? CO2-reducing enzymes like RuBisCO are notoriously slow and ineffective. However, import of HCO3- is typically coupled to ATP consumption...
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Duncan Kountz @dkountz.bsky.social · 15/01/2026
Thrilled to be able to finally post my first adventure into secondary metabolism!: Flavoaffinins, Elusive Cellulose-Binding Natural Products from an Anaerobic Bacterium pubs.acs.org/doi/full/10.... Co-authors: Ruocheng Yu, f. undergrad Jessie Lee, @katherinem.bsky.social , and Emily Balskus!
pubs.acs.org
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Fidel Ramírez-Amador @fidelormz.bsky.social · 08/12/2025
Last Friday was the defense of my PhD thesis entitled "Structural basis of anaerobic enzymes mediated by noncanonical metalloclusters" after 4 yrs at the @synmikro.bsky.social 🎓🎓 Big thanks to my supervisor @schullerjm.bsky.social and the whole Schuller lab for their continuous and massive support!
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Schuller Jan @schullerjm.bsky.social · 25/11/2025
The largest challenge of the day. Try to assemble 5 structural biology papers (each more than 100 pages incl. Supplements) in a single pdf with less than 15MB to upload as a document for a prize nomination for a student. Not sure compression algorithms are that good...
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Martin Thanbichler @thanbichlerlab.bsky.social · 02/11/2025
📢 Postdoc position: Cell Biology of Cyanobacteria in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany. More information at shorturl.at/wNnDT (see Project 2) 🔗Apply at shorturl.at/VsEDl 📅Deadline: Nov 16, 2025 Please repost. #Postdoc
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georghochberg.bsky.social @georghochberg.bsky.social · 24/09/2025
A new preprint from the lab. I won't do a tweetorial until this is peer reviewed, but I think it's a banger, led by @JedNzy. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can. www.biorxiv.org/content/10.1...
biorxiv.org
Origin of chaperone dependence and assembly complexity in Rubisco biogenesis
Molecular chaperones assist with the folding and assembly of protein clients. Consequently, they are essential to diverse cellular functions. In most aerobic photosynthetic organisms such as B-cyanoba...
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ProLOEWE @proloewe.bsky.social · 05/09/2025
Die aller♥️lichsten Glückwünsche🍾🥂auch von uns an Jan Schuller, Wissenschaftler👨🏼‍🔬bei LOEWE-Tree-M & zuvor bereits beim ehem. LOEWE-Zentrum SYNMIKRO, zu seinem #Explorationsstipendium der Boehringer Ingelheim Stiftung! @synmikro.bsky.social @loewe-tree-m.bsky.social.
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Francis O'Reilly @fjoreilly.bsky.social · 05/08/2025
‼️ Exciting new preprint from a close collaboration with Kylie Walters' group. Our study maps the binding sites of key regulators of the proteasome in situ. www.biorxiv.org/content/10.1...
biorxiv.org
Structures of dynamic interactors at native proteasomes by PhIX-MS and cryoelectron microscopy
Proteasome function depends on a network of transient interactions that remain structurally and functionally unresolved. We developed PhIX-MS (Photo-induced In situ Crosslinking-Mass Spectrometry), a ...
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Ville Kaila @kailalab.bsky.social · 01/08/2025
Thank you Knut and Alice Wallenberg Foundation for producing this wonderful video on our research, and for the generous long-term support on our work. youtu.be/A12FvTn812Q
youtu.be
He wants to reveal the secret behind the body's battery
YouTube video by Wallenbergstiftelserna
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Olalla Vázquez @olallalab.bsky.social · 29/07/2025
#PhDposition #OrganicChemistry #ChemBio - deadline 03.08 - please RT ❤️ Application online stellenangebote.uni-marburg.de/jobposting/d...
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Lisa Maier Lab | Tübingen @lisamaierlab.bsky.social · 16/07/2025
Finally online! Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections. rdcu.be/ewwrG
rdcu.be
Non-antibiotics disrupt colonization resistance against enteropathogens
Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...
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STCmicrobeblog @stcmicrobeblog.bsky.social · 21/06/2025
we were already happy that these fascinating microbes were called 𝗶𝗻𝘁𝗿𝗮𝘁𝗲𝗿𝗿𝗲𝘀𝘁𝗿𝗶𝗮𝗹𝗲𝘀, but 𝗮𝗲𝗼𝗻𝗼𝗽𝗵𝗶𝗹𝗲𝘀 sounds definitively more, well... scientific (😎) #MicroSky
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SchmitzStreitsLAB @schmitzstreitslab.bsky.social · 04/06/2025
Amazing paper, the best of two worlds- combination of high resolution cryoEM and small proteins - posttranslational Regulation of the core bioenergetic machinery of methanogenesis by a small protein! Well done Tristan and Eva!!👍🥂🥂 @schullerjm.bsky and @Schmitz-Streit lab - possible through @dfg.de
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Schuller Jan @schullerjm.bsky.social · 04/06/2025
Proud to present the lab's latest work. The full structure of the sodium translocating methyltransferase (Mtr) bound to a small oxygen-responsive small protein MtrI. Work by Tristan and together with @schmitzstreitslab.bsky.social . www.biorxiv.org/content/10.1101/2025.06.02.657420v1
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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 03/06/2025
Our structural core gene pipeline Unicode is now published at GBE 📄 doi.org/10.1093/gbe/... Please also check out @dongwookkim.bsky.social’s 🧵 bsky.app/profile/dong...
doi.org
Unicore Enables Scalable and Accurate Phylogenetic Reconstruction with Structural Core Genes
Abstract. The analysis of single-copy core genes, common to most members of a clade, is important for key tasks in biology including phylogenetic reconstru
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SchmitzStreitsLAB @schmitzstreitslab.bsky.social · 02/06/2025
Check out our latest preprint on small proteins with big impact: MtrR fine-tunes energy metabolism in M.mazei by modulating the Mtr complex in response to H₂. Great work of Tim Habenicht + @SPP2002 collegues + @schullerjm.bsky.social - congrats TIM, 2. step to PhD! www.biorxiv.org/content/10.1...
biorxiv.org
Small ORF16 modulates the Mtr complex activity in Methanosarcina mazei Gö1 depending on the molecular hydrogen availability
Small open reading frame (small ORF)-encoded proteins, with less than 100 amino acids in length, have attracted increasing attention over the past decade after being largely overlooked due to limitati...
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Randall Munroe @xkcd.com · 30/05/2025
Archaea xkcd.com/3095/
Comic. PERSON: It’s weird how, despite being one of the main branches of the tree of life, no archaea species are known to cause disease in humans. PERSON WITH SHORT HAIR: Personally, I think it’s because those gross methane breathers are too weird and incompetent to figure out how to hurt us even if they wanted to. [from small point under microscope on desk]: *Hey!* [caption] Bad news: After overhearing a conversation in our lab, Archaea has finally started harming humans.
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European Commission @ec.europa.eu · 23/05/2025
Here is one big reason to choose Europe to advance with your research career: We 💙 science.
Two scientists, a woman and a man, wearing safety goggles and lab coats, examine a robotic device. Overlaid text reads "Choose Europe – Freedom to explore, research and innovate. Discover how" with the European Union flag.

The EU flag is shown with a headline "Europe offers:" followed by a list: Stable funding and careers, Academic freedom and scientific excellence, High quality of life (healthcare, education, pensions), and Collaboration beyond borders.

Two young women smile while looking at a tablet, surrounded by EU stars. Text reads: "Choose Europe – €500 million for 2025–2027 to make Europe a magnet for researchers."
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Arjen Jakobi @cryotud.bsky.social · 22/05/2025
Want to try LocScale-2.0 without installing locally? Check out ColabScale: just upload your maps or enter your favourite EMDB ID and run LocScale-2.0 in the cloud. edu.nl/ur3ge
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Universität Marburg @unimarburg.bsky.social · 22/05/2025
🎉Doppelerfolg für die #UniMarburg in der Exzellenzstrategie! 🎉 Zwei Cluster zu Klimawandel und menschlicher Wahrnehmung sichern sich Förderung. Marburg beweist Forschungsstärke und Innovationskraft.🚀 @proloewe.bsky.social @synmikro.bsky.social @maxplanck.de @jlugiessen.bsky.social @tuda.bsky.social
uni-marburg.de
Marburg feiert Doppelerfolg in der Exzellenzstrategie
Zwei Cluster erhalten Förderung im wichtigsten deutschen Forschungswettbewerb
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Max Planck Institute for Terrestrial Microbiology @mpimicrobiomarburg.bsky.social · 22/05/2025
📢 Wir sind stolz und freuen uns, dass unser Exzellenzcluster Microbes-for-Climate (M4C) in der Exzellenzstrategie 2025 ausgewählt wurde! 🌟Wir freuen uns gemeinsam mit @unimarburg.bsky.social auf spannende #Mikrobenforschung - stay tuned ! @unimarburg.bsky.social @maxplanck.de‬ @synmikro.bsky.social
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Matt Johnson @profmattjohnson.bsky.social · 21/05/2025
Pleased to share my very general review of Photosynthesis now published in Nature Reviews Mol Cell Biol 🌞🌱 rdcu.be/em1lz Hopefully a useful primer for Postgrad and undergrad students
rdcu.be
Structure, regulation and assembly of the photosynthetic electron transport chain
Nature Reviews Molecular Cell Biology - The electron transfer chain in chloroplast thylakoid membranes uses solar energy to produce NADPH and ATP, which power carbon fixation into biomass. This...
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John Rubinstein @johnrubinstein.bsky.social · 16/05/2025
EtfD links beta oxidation to OxPhos in mycobacteria - recent work suggests that targeting EtfD could shorten #tubeculosis treatment. But how does EtfD work? And how can you assay its activity? In his final PhD manuscript @courbongautier.bsky.social provides answers! www.biorxiv.org/content/10.1...
A) Diagram showing how EtfD transfers electrons from beta oxidation to the menaquinol pool in the membrane, linking beta oxidation to oxidative phosphorylation in mycobacteria.
B) A growth curve showing the Mycobacterium smegmatis lacking EtfD can grow when glucose is provided as the carbon source, but has a slight growth delay. Complementing the ∆etfD strain with M. tuberculosis on a plasmid rescues the defect.
C) A growth curve showing that ∆etfD M. smegmatis cannot grow on medium where the fatty acid oleic acid is the only carbon source. A plasmid with with M. tuberculosis EtfD rescues the defect.
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bioRxiv Plant Bio @biorxiv-plants.bsky.social · 15/05/2025
Catch & Release - rapid cost-effective protein purification from plants using a DIY GFP-Trap-protease approach www.biorxiv.org/content/10.1101/202…
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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 15/05/2025
We've updated our AFESM website to now include biome filtering, allowing exploration of protein structures adapted to specific environments. 🌐 afesm.foldseek.com Read more about the work in the skeetorial 🦋 bsky.app/profile/mart... or our preprint 📄 www.biorxiv.org/content/10.1...
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Priya Ramakrishna @priyaramakrishna.bsky.social · 14/05/2025
🌱 Excited to share that I will start my lab at EPFL, CH this June supported by a @snsf.ch Starting Grant! ramakrishna.ch We are interested in plant mineral nutrition and will deep-dive into the fine-tuned mechanisms employed by plants to adapt to abiotic stresses such as salinity. #newPI #plantsci
ramakrishna.ch
Plant Adaptation Lab (PAL) – Situated at Institute of Environmental Engineering, EPFL, Switzerland
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Tanai Cardona @tanaicardona.bsky.social · 14/05/2025
Our paper: Structure and evolution of photosystem I in the early-branching cyanobacterium Anthocerotibacter panamensis is out now in PNAS! www.pnas.org/doi/10.1073/... Great collab with the labs of Ming-Yang Ho and Chris Girsiel.
pnas.org
Structure and evolution of photosystem I in the early-branching cyanobacterium Anthocerotibacter panamensis | PNAS
Thylakoid-free cyanobacteria are thought to preserve ancestral traits of early-evolving organisms capable of oxygenic photosynthesis. However, and ...
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