iiinova — where your digital self keeps evolving

Olivier Neyrolles @oneyrolles.bsky.social · 13/09/2026

𝐓𝐰𝐨 𝐬𝐭𝐮𝐝𝐢𝐞𝐬, 𝐨𝐧𝐞 𝐬𝐭𝐨𝐫𝐲: 𝐜𝐨𝐩𝐩𝐞𝐫, 𝐜𝐲𝐬𝐭𝐞𝐢𝐧𝐞 𝐚𝐧𝐝 𝐫𝐞𝐝𝐨𝐱 𝐚𝐝𝐚𝐩𝐭𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝑴. 𝒕𝒖𝒃𝒆𝒓𝒄𝒖𝒍𝒐𝒔𝒊𝒔 Our new @mbio.bsky.social paper shows that copper reaches intracellular M. tuberculosis and strongly induces CysK2, a cysteine synthase linking copper sensing to redox adaptation and persistence. 📖 shorturl.at/PSDbk

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Luiz Pedro Carvalho, PhD @luizcarvalholab.bsky.social · 21/08/2026

Wow. In a previously unknown toxin-antitoxin system (RelS-RelI) the RelS toxin halts bacterial growth by cleaving 16S rRNA at a unique site in the anti-Shine-Dalgarno region. Beautiful use of comparative genomics at the species level, powerful. @oneyrolles.bsky.social Makarova & Genevaux.

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CNRS Biologie @cnrsbiologie.bsky.social · 02/07/2026

#ResultatScientifique🔎| Camille Attané et ses collaborateurs décrivent une population de cellules jusqu'alors inconnue dans la moelle osseuse humaine ! 👋 @ipbstoulouse.bsky.social 📕 @cp-cellreports.bsky.social À lire sur notre site internet ! ⤵️

buff.ly

Un nouveau type de cellules graisseuses sans noyau découvertes dans la moelle osseuse humaine

Dans u

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Alexandra Delbot @alexandradelbot.bsky.social · 02/06/2026

Une méta-analyse de 100 études menées dans 36 pays montre que les citoyens préfèrent généralement les migrants qualifiés et maîtrisant la langue du pays d’accueil. Mais elle révèle aussi des attitudes envers l'immigration globalement plus positives que ne le suggère le débat public.

radiofrance.fr

Attitudes face à l'immigration : préfère-t-on certains immigrés à d'autres ?

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CNRS @cnrs.fr · 30/05/2026

Le #CNRS perd aujourd'hui l'une de ses figures les plus marquantes. Sociologue, penseur de la complexité et directeur de recherche émérite, #EdgarMorin a consacré sa vie à faire dialoguer les disciplines pour mieux comprendre le monde et l'humain. lejournal.cnrs.fr/articles/edg...

lejournal.cnrs.fr

Edgar Morin, un cheminement intellectuel

Edgar Morin est décédé ce 29 mai 2026. Nous republions ici le portrait que nous avions consacré à l’intellectuel le plus célèbre de France lors de son centenaire, retraçant huit décennies d’un parcour...

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jobRxiv @jobrxiv.org · 24/03/2026

Karolinska Institute is hiring for 9 new positions! Individual job details below!👇 #ScienceJobs

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Olivier Neyrolles @oneyrolles.bsky.social · 19/03/2026

Truly humbled and deeply honored to have been elected a Fellow of the European Academy of #Microbiology, @femsmicro.org Profoundly grateful to my mentors, collaborators, colleagues, and students, past and present, whose guidance, creativity, and dedication have shaped this journey 🙏 ♥️

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Alexandre Gouzy @alexandregouzy.bsky.social · 11/03/2026

I’m pleased 🤗 to share our new preprint exploring the mode of action and resistance of the antitubercular drug pyrazinamide (PZA) 💊 Thanks to everyone who have participated 🙌 We hope these findings will help the fight against drug resistance in tuberculosis. www.biorxiv.org/content/10.6...

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Olivier Neyrolles @oneyrolles.bsky.social · 12/03/2026

AI agent Fleming accelerates antibiotic discovery for Mycobacterium tuberculosis by integrating generative and predictive models, achieving 83% in-vitro hit rates and identifying novel compounds with favorable ADMET profiles across unexplored chemical space. www.biorxiv.org/content/10.1...

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 25/02/2026

🚨 𝐀𝐈 𝐦𝐞𝐞𝐭𝐬 𝐓𝐁 𝐝𝐫𝐮𝐠 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲! Imaging 𝐶. 𝑔𝑙𝑢𝑡𝑎𝑚𝑖𝑐𝑢𝑚 (a model for 𝑀. 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠) + deep learning reveals known, unseen, and novel antibiotic modes of action from images alone, a leap for TB drug discovery. ✍️ @awehenkel.bsky.social & coll. 📖 shorturl.at/9QPDy #Tuberculosis #MicroSky

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Geanncarlo Lugo @gclugo.bsky.social · 20/02/2026

Our new paper is out in @lsajournal.org We explored how glycolysis inhibition in tuberculosis-infected macrophages can reduce HIV-1 spread. 🔗 Read it here: doi.org/10.26508/lsa... Huge thanks to @Zoi Vahlas, @lucianabalboa.bsky.social, @oneyrolles.bsky.social & @chrisverollet.bsky.social

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The EMBO Journal @embojournal.org · 13/02/2026

How can bacterial pathogens weather metal ion stress during infection? @pierredupuy.bsky.social, @oneyrolles.bsky.social et al implicate ‘effluxosomes’, membrane clusters of metal-binding chaperones & exporters coordinating M. tuberculosis resistance to toxic metals link.springer.com/article/10.1...

link.springer.com

Membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis - The EMBO Journal

Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a prev...

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CNRS Biologie @cnrsbiologie.bsky.social · 13/02/2026

#ResultatScientifique🔎| La bactérie responsable de la tuberculose est capable d'évacuer les métaux toxiques pour résister au système immunitaire ✍️ @oneyrolles.bsky.social 🤝 @ipbstoulouse.bsky.social 📕 buff.ly/4R5iaMB ▶️

buff.ly

Tuberculose : comment la bactérie évacue les métaux toxiques pour résister au système immunitaire

Le bacille de la tuberculose survit dans les cellules immunitaires en neutralisant des métaux toxiques comme le zinc.

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Olivier Neyrolles @oneyrolles.bsky.social · 13/02/2026

🎉 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐧𝐞𝐰 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐓𝐡𝐞 𝐄𝐌𝐁𝐎 𝐉𝐨𝐮𝐫𝐧𝐚𝐥! After 8 months of revision, our work is now online: shorturl.at/WHmFq We uncover a previously unrecognized way that 𝑀𝑦𝑐𝑜𝑏𝑎𝑐𝑡𝑒𝑟𝑖𝑢𝑚 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠 survives toxic metal stress during infection. ...

shorturl.at

Membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis - The EMBO Journal

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Olivier Neyrolles @oneyrolles.bsky.social · 29/01/2026

So inspiring to see the next generation of researchers in action. Their science gets clearer and more impactful every year. Watching Max Caouaille and Aizat Abdul at #TBVAC was genuinely moving. Great science, great storytelling, huge passion. The future of research is in very good hands. 👏

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Daniel L. Barber, PhD @danbarberphd.bsky.social · 15/01/2026

The Barber lab is looking to hire post-docs to work on #tuberculosis #immunology using murine and NHP models. BSL3 experience not required. Check out our lab in the NIH intramural program in Bethesda MD!

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Max Gutierrez @maxgg.bsky.social · 12/01/2026

A great meeting ahead for host and pathogen aficionados! Keynote speakers: Florence Niedergang (Cochin) and Raphael Valdivia (Duke)- plenty of opportunities for early career researchers to present their work and a very collegial and supportive network. Belfast here we go! Please repost.

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Olivier Neyrolles @oneyrolles.bsky.social · 13/01/2026

🥳 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐥𝐚𝐭𝐞𝐬𝐭 𝐰𝐨𝐫𝐤 𝐬𝐡𝐨𝐰𝐢𝐧𝐠 𝐡𝐨𝐰 𝐩𝐨𝐥𝐲𝐬𝐢𝐚𝐥𝐲𝐥𝐚𝐭𝐢𝐨𝐧, 𝐚 𝐫𝐚𝐫𝐞 𝐩𝐫𝐨𝐭𝐞𝐢𝐧 𝐦𝐨𝐝𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧, 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐞𝐬 𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐨𝐫𝐲 𝐦𝐨𝐧𝐨𝐜𝐲𝐭𝐞 𝐦𝐨𝐛𝐢𝐥𝐢𝐳𝐚𝐭𝐢𝐨𝐧 𝐟𝐫𝐨𝐦 𝐭𝐡𝐞 𝐛𝐨𝐧𝐞 𝐦𝐚𝐫𝐫𝐨𝐰. ✍️ Aurélien Boyancé, Nelly Gilles, @yoannrombouts.bsky.social & coll. @ipbstoulouse.bsky.social 📖 shorturl.at/IDwza 👇 A short thread...

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Olivier Neyrolles @oneyrolles.bsky.social · 08/01/2026

Nothing like a good meal with an even better team. Here’s to a bright, productive 2026! 🤩 @mcaouaille.bsky.social @saurabhchugh09.bsky.social @vogeleerp.bsky.social @yoannrombouts.bsky.social & more!

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Bryan Bryson @thebrysonlab.bsky.social · 18/12/2025

Two pieces of fun news: 1. We've launched a new website for our lab: www.brysonlab.org 2. With some new funding, we are recruiting for new postdocs and graduate students. The projects build upon our previous studies of antigen presentation and phagosome biology and go into new exciting dimensions!

brysonlab.org

The Bryson Lab | Vaccine Development & Research at MIT

Developing effective accessible vaccines to end tuberculosis worldwide. Combining immunoengineering, molecular microbiology & systems biology at MIT.

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IPBS Toulouse @ipbstoulouse.bsky.social · 18/12/2025

🚨 We are excited to announce that @virginiestevenin.bsky.social has been awarded a starting grant from the @frm-officiel.bsky.social to establish her research team at IPBS and study the nutrition of pathogenic bacteria inside human host cells. More info: shorturl.at/U6zSa #MicroSky #Salmonella

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Olivier Neyrolles @oneyrolles.bsky.social · 12/12/2025

A big thank-you to @sheetalgandotra.bsky.social & @vivekrao.bsky.social and everyone at CSIR-IGIB for their warm welcome! 😊 What a wonderful day with incredibly friendly hosts and such brilliant, motivated students! 🇫🇷🇮🇳 Long live Franco-Indian cooperation!

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Olivier Neyrolles @oneyrolles.bsky.social · 11/12/2025

🚨 𝐍𝐞𝐰 𝐩𝐫𝐞𝐩𝐫𝐢𝐧𝐭 𝐟𝐫𝐨𝐦 𝐨𝐮𝐫 𝐥𝐚𝐛, 𝐚𝐧𝐝 𝐚 𝐟𝐢𝐫𝐬𝐭 𝐢𝐧 𝐭𝐡𝐞 𝐓𝐁 𝐟𝐢𝐞𝐥𝐝! 🚨 We’re thrilled to share our new study revealing how the chromatin regulator SP140 preserves protective T cell immunity during #tuberculosis infection by restraining harmful type I IFN responses. 📖 𝗥𝗲𝗮𝗱 𝘁𝗵𝗲 𝗽𝗿𝗲𝗽𝗿𝗶𝗻𝘁: shorturl.at/r5jd9

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Olivier Neyrolles @oneyrolles.bsky.social · 05/12/2025

𝗜𝗣𝗕𝗦 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵𝗲𝗿𝘀 𝗶𝘀𝗼𝗹𝗮𝘁𝗲𝗱 𝗵𝘂𝗺𝗮𝗻 𝗿𝗲𝗴𝘂𝗹𝗮𝘁𝗼𝗿𝘆 𝗯𝗼𝗻𝗲 𝗺𝗮𝗿𝗿𝗼𝘄 𝗮𝗱𝗶𝗽𝗼𝗰𝘆𝘁𝗲𝘀 𝗳𝗼𝗿 𝘁𝗵𝗲 𝗳𝗶𝗿𝘀𝘁 𝘁𝗶𝗺𝗲! These anucleate fat cells still metabolize lipids and glucose, support blood cell production, and may shape the bone marrow niche and hematopoiesis.🩸 📖 shorturl.at/bunUV #Hematopoiesis #Adipocytes #BoneMarrow

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Joanne Flynn @joanneflynn19.bsky.social · 04/12/2025

Hey friends. I’m looking for a postdoc interested in studying host-pathogen interactions and immunology of tuberculosis. Send me some good people! We have a great group here! Email me joanne@pitt.edu. Thanks!

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IPBS Toulouse @ipbstoulouse.bsky.social · 03/12/2025

IPBS researchers created LiveLung-TB, a BSL-3 imaging platform that visualizes real-time immune responses in Mtb-infected lungs. They found most CD4 T cells fail to reach infected cells, revealing physical barriers that limit TB immunity—a new window into host-pathogen dynamics! 🔬🫁 #Tuberculosis

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Mélanie Foulon @mel-foulon.bsky.social · 20/11/2025

Why would Mycobacterium shed its surface right after entering a host cell? Host phagocytes rapidly strip its outer layer, releasing components that alert neighbors and trigger defense responses Our preprint is out, curious to hear your take! 👀 www.biorxiv.org/content/10.1...

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Max Gutierrez @maxgg.bsky.social · 19/11/2025

👇👇Last days to submit your abstract to be considered for a short talk! Deadline 24 November!https://www.keystonesymposia.org/conferences/conference-listing/meeting/travel/c42026

keystonesymposia.org

Tuberculosis: Understanding the Disease Across Scales | Keystone Symposia

Join us at the Keystone Symposia on Tuberculosis: Understanding the Disease Across Scales, March 2026, in Cape Town, with field leaders!

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 18/11/2025

Two M. tuberculosis RelE toxins don’t cut mRNA, they slice 16S rRNA itself, shutting down translation in a totally unexpected way, new study reveals. A big leap in understanding TB’s survival tricks and new angles for therapies. 📖 shorturl.at/Z8MVX ✍️ @genevauxpierre.bsky.social & coll. #MicroSky

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Olivier Neyrolles @oneyrolles.bsky.social · 13/11/2025

👏👏👏 So proud of our co-PI! This well-deserved recognition honors Luciana’s outstanding scientific contributions, her dedication to mentoring, and her support for young women in research. Please join me in congratulating her on this incredible achievement!

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IPBS Toulouse @ipbstoulouse.bsky.social · 05/11/2025

Un immense merci à nos doctorants, au comité organisateur et à nos orateurs invités @mblokesch.bsky.social, F. Mechta-Grigoriou & E. Crubezy, pour la réussite de ce superbe 10e Symposium des étudiants de l’IPBS. Bravo à toutes et à tous ! Cap sur le 11e Symposium !

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IPBS Toulouse @ipbstoulouse.bsky.social · 05/11/2025

A huge thank you to our PhD students, the organizing committee, and our guest speakers @mblokesch.bsky.social, F. Mechta-Grigoriou & E. Crubezy for making the 10th IPBS Student Symposium such a success. Kudos to everyone involved! On to the 11th Symposium! 🎉

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IPBS Toulouse @ipbstoulouse.bsky.social · 04/11/2025

Exciting #postdoc opportunity in T. Gensollen's group! How early-life interactions between the immune system and microbiota shape lifelong immune imprinting and disease risk Learn more: shorturl.at/F8hqE Deadline: January 15, 2026 Contact: recruit@ipbs.fr #Immunology #Microbiology #Microbiota #Omics

shorturl.at

Early-life Immune Imprinting and Inflammatory Diseases - IPBS-Toulouse

Our team studies neonatal immunity. We are particularly interested in mapping the mucosal cell subsets[…]

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IPBS Toulouse @ipbstoulouse.bsky.social · 04/11/2025

Exciting #postdoc opportunity in KL Ung's group! Understanding the molecular mechanisms of cell wall remodeling in pathogens Learn more: shorturl.at/gPuFV Deadline: January 15, 2026 Contact: recruit@ipbs.fr #Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM

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Journal of Experimental Medicine @jem.org · 28/10/2025

Insights from Andrea Cooper: Mtb drives expression of type I IFN–mediated #neutrophil accumulation, which limits interaction btwn CD4 T cells & macrophages. Failure to limit type I IFN very early in the process allows rapid progression of disease rupress.org/jem/article/... #Tuberculosis

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Olivier Neyrolles @oneyrolles.bsky.social · 29/10/2025

Women's medicine, a 'bikini medicine'… « You do realize we have other organs too, right? » That joke is so true, unfortunately! ✍️ Camille Van Belle

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Olivier Neyrolles @oneyrolles.bsky.social · 27/10/2025

👏👏👏 Ophélie Dufrançais, @chrisverollet.bsky.social et leurs collègues ! Un travail soutenu par @frm-officiel.bsky.social et @agencerecherche.bsky.social et réalisé en collaboration avec @lp2mlab.bsky.social et @embl.org, entre autres.

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IPBS Toulouse @ipbstoulouse.bsky.social · 27/10/2025

Des chercheurs de l’IPBS (@chrisverollet.bsky.social et coll.) ont découvert que la protéine moésine régule les ostéoclastes, les cellules qui résorbent l’os. Sans elle, les os s’affaiblissent. Une piste prometteuse contre l’ #ostéoporose. 📘 @jcb.org shorturl.at/OhNSa

shorturl.at

La protéine Moésine régule le remodelage osseux en modulant la fusion et l’activité des ostéoclastes - IPBS-Toulouse

Des chercheurs de l’Institut de Pharmacologie et Biologie Structurale (IPBS) ont mis en évidence un[…]

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IPBS Toulouse @ipbstoulouse.bsky.social · 27/10/2025

Too much cell fusion can break your bones, literally! IPBS researchers @chrisverollet.bsky.social & coll. found that moesin keeps bone-resorbing cells (osteoclasts) in check. Without it, bones weaken, a discovery that could inspire new #osteoporosis treatments. 📘 @jcb.org shorturl.at/N0Esc

ipbs.fr

Moesin Protein Controls Bone Remodeling by Regulating Osteoclast Fusion and Function - IPBS-Toulouse

Researchers at the Institut de Pharmacologie et Biologie Structurale (IPBS) have uncovered a pivotal role[…]

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Tom Scriba @tomscriba.bsky.social · 09/10/2025

We are inviting applications for postdoctoral fellows in immunology of TB at the South African Tuberculosis Vaccine Initiative, University of Cape Town. For more information see the attached ad: idm.uct.ac.za/media/739223

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Cascales Lab @cascaleslab.bsky.social · 09/10/2025

Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here: emploi.cnrs.fr/Offres/Docto...

emploi.cnrs.fr

Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F)

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Olivier Neyrolles @oneyrolles.bsky.social · 09/10/2025

What a fantastic event! Thanks to @carobarisch.bsky.social, Oliver Jäckle-Tietjen, and the amazing students for the kind invite and great organization. Such a pleasure to join! 🤩 @fzborstel.bsky.social

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Olivier Neyrolles @oneyrolles.bsky.social · 08/10/2025

What an honor and joy to speak at Borsteler Herrenhaus for #NDI3 2025! Thrilled to reconnect with friends & colleagues. Special thanks to the brilliant students and @carobarisch.bsky.social for the kind invite & flawless organization! #Immunology #InfectionBiology #NordInfect Fotos: Kerstin Pukall

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Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 08/10/2025

A big thank you to our Scientific Advisory Board for their engagement during out meeting this week. So many thoughtful questions and insightful comments! Hans-Georg Kräusslich, @oneyrolles.bsky.social, @sykhalid.bsky.social, @thamlab.bsky.social, Joost Enninga, Friedrich Förster, Ilaria Ferlenghi

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