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Léa Swistak

@leaswistak.bsky.social

132 followers 138 following 5 posts

🇪🇺 | Cellular microbiology | Cryo-ET | EIPOD-LinC postdoctoral fellow Mahamid lab @EMBL | Before PhD in the Enninga lab @InstitutPasteur

Posts Replies Media

Reposted by Léa Swistak

EMBL Events @events.embl.org · 15/09/2026

Interested in gaining a theoretical foundation along with hands-on practice in Correlative Light and Electron Microscopy (CLEM) in both room temperature and cryogenic conditions? Then join us for #EMBOCLEM 🔬 🧪 s.embl.org/lem27-01-bl EMBL Heidelberg 31 Jan – 5 Feb 2027 Apply by: 25 Oct 2026

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Léa Swistak @leaswistak.bsky.social · 26/06/2026

Congrats everyone !!

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Reposted by Léa Swistak

EMBO Reports @emboreports.org · 26/06/2026

Margot Sahnine, Dorian Obino and co-workers @pasteur.fr show that N. meningitidis induces membrane protrusions with distinct #F-actin networks in epithelial and endothelial cells. The branched network in endothelia depends on Arf1. #Host-pathogen #membrane -> link.springer.com/article/10.1...

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Léa Swistak @leaswistak.bsky.social · 09/05/2026

LowDoseWitzard: Use it, love it, adopt it!

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Reposted by Léa Swistak

joe dobbs @joedobbs.bsky.social · 22/04/2026

See also our preprint about the microscope itself, which went up earlier this afternoon! www.biorxiv.org/content/10.6...

biorxiv.org

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Reposted by Léa Swistak

joe dobbs @joedobbs.bsky.social · 22/04/2026

Big news for correlative cryogenic SMLM/ET! With my colleague Soheil, we (Mahamid and @jonasries.bsky.social labs) indicate lamella-specific illumination can allow 500-1500x higher laser intensities, opening massive new possibilities for correlative imaging #teamtomo www.biorxiv.org/content/10.6...

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Reposted by Léa Swistak

Veijo Salo @veijosalo.bsky.social · 18/12/2025

Excited to share that as my group launches across Karolinska Institutet and the University of Helsinki, we’re recruiting postdocs and research assistants to study the nanoscale architecture of lipid flux using in-cell structural biology approaches, including cryo-ET and cryo-CLEM

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Reposted by Léa Swistak

EMBL @embl.org · 11/12/2025

Congratulations, Julia Mahamid! Julia Mahamid receives the @dfg.de Leibniz Prize for her work on structural cell biology! #LeibnizPreis

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Reposted by Léa Swistak

joe dobbs @joedobbs.bsky.social · 19/07/2025

New paper from my colleague Soheil in the Mahamid and @jonasries.bsky.social groups looking at factors influencing laser devitrification on frozen #cryoem samples. With a far-red fluorophore, all-gold support grids will be especially good for correlative cryo-SMLM and EM! doi.org/10.1016/j.js...

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Reposted by Léa Swistak

The Shigella Meeting @shigellameeting.bsky.social · 27/05/2025

Only 328 days to go! We're very busy behind the scenes getting thigns ready for the meeting! In the meantime you can add your email address for updates here: coming-soon.embo.org/w26-04

coming-soon.embo.org

Shigella, the first international meeting

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Léa Swistak @leaswistak.bsky.social · 26/05/2025

Diving “Google earth mode 🌍” in a Shigella infected cell 🔬🔎 Together with @m-albert.bsky.social

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Reposted by Léa Swistak

PLOS Biology @plosbiology.org · 02/05/2025

How do intracellular #bacteria breach vacuoles to enter the host cytosol? @leaswistak.bsky.social @matthijnvos.bsky.social @enningalab.bsky.social &co show that #Shigella uses its T3SS system to damage endomembranes via mechanoporation to initiate cytosolic access @plosbiology.org 🧪 plos.io/4jXrr9Z

Left: Group of three T3SS localizing in the same zone of the bacteria surface. T3SS n°1 and 2 contact, deform, and perforate the vacuole membrane at the same spot. T3SS n°1 needle (83 nm) is long and seems to deviate from basal body axis showing that strong constraints between T3SS and the vacuole at are play. The locally relaxed vacuole to bacteria space (~50–55 nm) potentially limits additional damage by the T3SS n°3 needle (56 nm) that only slightly deforms the membrane. Right: Model of initial vacuolar membrane breaching by T3SS-induced mechanoporation. Shigella actively enters host cells in a specialized endomembrane compartment, the vacuole, that is rapidly injured and ruptured for cytosolic access. After host cell entry, the vacuole membrane is intact and tightly juxtaposed to the surface of Shigella, permitting contact between T3SSs and the endomembrane. In the authors’ proposed model, vacuole membrane injury is supported both by the vacuole tightness and the length of individual T3SSs.

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Léa Swistak @leaswistak.bsky.social · 17/02/2025

Great event! Super experience as a speaker/trainer. Looking forward for the next edition 😄

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