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Julie Le Bris

@julielebris.bsky.social
1.3K followers 695 following 28 posts

PhD student interested in microbial evolution and ecology🧬 @Institut Pasteur #Klebsiella #MicroSky

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Reposted by Julie Le Bris
FEMS Journals @femsjournals.bsky.social · 01/08/2026
How does epithelial polarity shape Chlamydia trachomatis infection? 🦠 🧫 In this review, Hovhannisyan & Rudel @uni-wuerzburg.de highlight this overlooked aspect of host–pathogen interactions and its impact on disease. 👉️ buff.ly/lyElCoY
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FEMS Journals @femsjournals.bsky.social · 16/07/2026
How do commensal bacteria protect against pathogens? @jmghigolab.bsky.social lab identified CSAP-1, a pore-forming protein that mediates bacterial competition and enhances infected zebrafish survival —a promising lead for aquaculture antimicrobial strategies. 👉️ buff.ly/HSn0tLP @pasteur.fr
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Olaya Rendueles @olayarendueles.bsky.social · 01/06/2026
🌟 Very proud of the newest Dr. in the team , Dr. @julielebris.bsky.social 👩‍🎓! She brilliantly defended her PhD last Friday @pasteur.fr Excellent thesis in terms of output & quality! Thanks to the jury @lucyweinert.bsky.social @sylvainbrisse.bsky.social @edfeil.bsky.social Maria Halima Laaberki
The big moment
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Olaya Rendueles @olayarendueles.bsky.social · 19/05/2026
🔬🦠 Comment #Klebsiella parvient-elle à changer de capsule aussi fréquemment pour mieux s’adapter à son environnement ? Les travaux de @julielebris.bsky.social mis à la une par @cnrsbiologie.bsky.social 👏 -avec @epcrocha.bsky.social #MicroSky @cbitoulouse.bsky.social
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CNRS Biologie @cnrsbiologie.bsky.social · 19/05/2026
#ResultatScientifique🔎| Une bactérie capable de changer de « bouclier » pour mieux s’adapter à son environnement : une stratégie étonnante de Klebsiella pneumoniae qui éclaire ses capacités d’évolution et de résistance. ✍️ @olayarendueles.bsky.social @julielebris.bsky.social ▶️ buff.ly/q8AKHo1
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FEMS Journals @femsjournals.bsky.social · 03/05/2026
TraF from a broad-host monoderm plasmid is the first conjugative T4SS component with strong homology to T7SS pseudokinase 🧬 Grohmann & Keller labs elucidate its crystal structure, function and partners. @uni-grat.at & BHT_berliner 👉️ buff.ly/ndoiPD4
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FEMS Journals @femsjournals.bsky.social · 27/04/2026
A new era of bacteriophage research is underway. microLife’s thematic issue on Viruses of Microbes brings together studies exploring bacterial immunity, the role of phages in microbiomes, & their growing use in molecular biology & next-gen phage therapy. Explore the thematic issue: buff.ly/f8rLFus
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FEMS Journals @femsjournals.bsky.social · 18/04/2026
Fluorescent labeling extended to 3 streptococcal species 🧫✨ @veeninglab.com & coll. benchmarked 5 proteins and developed multicolor cassettes enabling triple labeling—expanding tools for gene expression, cell dynamics & infection studies. 👉️ buff.ly/DFMXjE7
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Eduardo Rocha @epcrocha.bsky.social · 27/03/2026
What happens when Klebsiella's capsule locus is swapped? Unexpectedly little in terms of cell growth. Yet, it does change the bacterium's environment and interactions with it: evolution by seamless plug-and-play capsule swap. Led by @julielebris.bsky.social @olayarendueles.bsky.social
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Olaya Rendueles @olayarendueles.bsky.social · 27/03/2026
Our latest manuscript explores capsule exchangeability & phenotypic portability We didn’t directly address its role in #virulence ⏩️ that was already elegantly shown here—worth a look 👀👇🏻 doi.org/10.1371/jour... 🎯 Their results supports our plug-and-play model! Bonus: we kept 🐭 alive #microsky
doi.org
Capsule type defines the capability of Klebsiella pneumoniae in evading Kupffer cell capture in the liver
Author summary Klebsiella pneumoniae is a major human pathogen. While capsule is the main virulence factor of the pathogen, only several of more than 80 capsule serotypes are frequently identified in ...
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Reposted by Julie Le Bris
Olaya Rendueles @olayarendueles.bsky.social · 26/03/2026
So happy to see this finally published in @plosbiology.org! This is the first chapter of @julielebris.bsky.social PhD thesis demonstrating how capsules are exchanged by plug-and-play dynamics w/ @epcrocha.bsky.social #microsky @klebclub.bsky.social Link below- Check out her 🧵 for more details!
doi.org
Plug-and-play evolution of the Klebsiella pneumoniae capsule locus enables serotype exchange across genetic backgrounds
How complex multi-gene systems evolve across genetic backgrounds without disruptive epistasis remains unclear, particularly in highly exchangeable loci such as the capsule of Klebsiella pneumoniae. Th...
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PLOS Biology @plosbiology.org · 26/03/2026
How do multi-gene systems evolve across genetic backgrounds without disruptive epistasis? @julielebris.bsky.social @olayarendueles.bsky.social &co show the #Klebsiella capsule locus is a plug&play module that swaps with low fitness cost while preserving #virulence @plosbiology.org 🧪 plos.io/4s64Ko0
Characteristics and capsule production of capsule-swapped strains. Genetic (lower triangle) and biochemical (upper triangle) relatedness between the different capsule types analyzed in this study. Biochemical similarity was calculated as the percentage of residues shared between two K types (# of shared unique oligosaccharides/# of different nonredundant oligosaccharides). Oligosaccharidic compositions and models were taken from K-PAM. Genetic relatedness was calculated taking into account all homologous genes between two K types. Monosaccharides composing the different capsules are depicted according to the Symbol Nomenclature for Glycans convention.
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FEMS Journals @femsjournals.bsky.social · 10/03/2026
🦠 How does #Salmonella find #iron in the gut? @ferrytin.bsky.social & colleagues show acidic pH pushes it to switch from using endogeneous to exogeneous #siderophores—revealing a flexible, pH-driven iron uptake strategy. 👉 buff.ly/90EZoqQ
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FEMS Journals @femsjournals.bsky.social · 03/03/2026
🦠 Beyond classic probiotics: @schmitzstreitslab.bsky.social lab reveals diverse #Bacteroidota gut strains that block #biofilms of major pathogens. Many also disrupt quorum sensing & show bile salt hydrolase activity—expanding the #microbiome toolbox against infection. 👉 buff.ly/sjPk8ZD
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Pedro Dorado-Morales @doradomoralesp.bsky.social · 26/02/2026
New preprint out on bioRxiv! www.biorxiv.org/content/10.6... Can conjugative plasmids be used to control plasmid and pathogen spread? Follow me down the rabbit hole that led to this story 🧵
biorxiv.org
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FEMS Journals @femsjournals.bsky.social · 31/01/2026
🧬 Dive into the small proteome of Methanosarcina mazei (across 5 conditions)! A key resource by @schmitzstreitslab.bsky.social @uni-kiel.de for uncovering #smallproteins functions, motifs and proteoforms in #archaea. 👉 buff.ly/HJOi3E0
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FEMS Journals @femsjournals.bsky.social · 26/01/2026
🦠 @laurentterradot.bsky.social lab reviews #Brucella’s #T4SS—a key virulence factor—covering its structure, function, and growing effector arsenal. It also explores how effectors enter host cells, opening new paths to understand and target infection. 🔬 👉 buff.ly/KW4kVN4
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Olaya Rendueles @olayarendueles.bsky.social · 15/01/2026
My team at @cbitoulouse.bsky.social is recruiting a postdoc #bioinformatics with solid experience in metagenomic analyses. Interest in evolution, ecology & MGEs is important. The offer stands until the perfect candidate is found, and it could be you 🫵 🔁 🙏 #microSky #phagesky #UTIsky @cnrs.fr
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FEMS Journals @femsjournals.bsky.social · 13/01/2026
@archaellum.bsky.social lab reveals how #cdiAMP and 4 RCK proteins shape osmotic stress responses in H. volcanii 🧬🦠. In highly halophilic #archaea, c-di-AMP coordinates ion balance and cell volume—mirroring bacterial strategies for environmental stress adaptation. 👉 buff.ly/ApWkCtg
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FEMS Journals @femsjournals.bsky.social · 09/01/2026
Review –by J. Yuan @mpimicrobiomarburg.bsky.social, HG. Koch & B. Berghoff— highlights bacterial small membrane proteins (SMPs) 🧫: from regulating membrane targets and insertion pathways to toxin roles. SMPs also offer potential as tools and templates for new antibiotics.💊 👉 buff.ly/9UzCwF2
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FEMS Journals @femsjournals.bsky.social · 05/01/2026
As 2026 begins, the EAM, @Vdlorenzo.bsky.social, Paul B. Rainey and many others remind us the urgency of renewing support to Society Journals and, taking action to reward quality research and curb predatory publishing. 👉 buff.ly/V36xgMO 👉 buff.ly/T8QE90G
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FEMS Journals @femsjournals.bsky.social · 30/11/2025
🦠Insight into the resilient world of prokaryotes! Koch lab – @sfb1381.bsky.social – reveals that E.coli use small membrane proteins (YohP & YncL) to condense their DNA & slow down metabolism, helping them survive to stresses. 🧬 buff.ly/dMzcQsP
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International Microbiology Literacy Initiative - IMiLI @imili-micro.bsky.social · 20/11/2025
Everything you need to explain AMR to family and friends-12: @pablolaborda.bsky.social @crisherencias.bsky.social @pharmageddon.bsky.social @ecdc.europa.eu @eberllab.bsky.social @klebclub.bsky.social ‪ @olayarendueles.bsky.social‬ the ESKAPE Rogues www.imili-eah.com/prod-api/pro...
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FEMS Journals @femsjournals.bsky.social · 17/11/2025
New insights into #Hpylori’s virulence machinery 🕵️🧪 Josenhans lab & coll. unravel new interactions between CagT4SS surface proteins and outer membrane proteins HopQ & HopZ—key for host interaction and #proinflammatory signaling. 🦠 @lmumuenchen.bsky.social 👉 buff.ly/toApn0c
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FEMS Journals @femsjournals.bsky.social · 06/11/2025
🦠 Small changes, big defense! Jordan Vacheron & coll. show specific SNPs in #Pseudomonas protegens CHA0 (algC & ykcC) remodel LPS to block #phage ΦGP100—while growth, competitiveness & root colonization stay intact, in lab conditions. 🧬 @unil.bsky.social 👉 buff.ly/MFOH2er
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FEMS Journals @femsjournals.bsky.social · 03/11/2025
What can an “orphan” #Cas4 do? 🧫 In #archaea M. mazei, Solo-Cas4 cleaves dsDNA in a metal-dependent manner and is upregulated in stationary phase—hinting at roles in stress or DNA metabolism. Biochemical characterization by Schmitz lab @uni-kiel.de 👉 buff.ly/kpz0yZ1
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FEMS Journals @femsjournals.bsky.social · 02/11/2025
#C.albicans invades tissues as hyphae but spreads as yeast, How? @jlspragu.bsky.social & coll. show yeast can reach the bloodstream by hitchhiking with invasive hyphae or by switching forms. 🧫 More clues for understanding systemic infections ! 👉 buff.ly/0vklJeb
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FEMS Journals @femsjournals.bsky.social · 27/10/2025
🔍 From rods to stars, bacteria craft their shapes using bPBPs & GTases. Garcia-del Portillo lab’s global analysis reveals unexpected diversity & flexibility in these morphogenetic complexes. 🦠 @cnb-csic.bsky.social 👉 Read more : buff.ly/D0pMhMr
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FEMS Journals @femsjournals.bsky.social · 21/10/2025
De-DUFing the DUFs 🧩 @franznarberhaus.bsky.social lab uncovers how small DUF1127 proteins regulate #phosphate uptake by binding the sensor kinase PhoR. Their conserved role from Agrobacterium to E. coli highlights how even small DUFs can shape bacterial physiology 🦠 buff.ly/jJd9Eho
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FEMS Journals @femsjournals.bsky.social · 17/10/2025
New insights from #CRISPR-Cas systems! 🧬 @cyanolab.bsky.social reveals that in the #cyanobacteria Synechocystis, RNase J works with RNase E to mature CRISPR3 RNAs—key for RNA-based immune defense. RNase J can also team up with PNPase in a degradosome-like complex. buff.ly/CrxiQPy
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FEMS Journals @femsjournals.bsky.social · 14/10/2025
New tools unlock #Bdellovibrio bacteriovorus’s predatory secrets 🦠. By combining inducible gene expression with #CRISPRi-mediated depletion for precise control of essential genes, @lalouxlab.bsky.social uncovered new insights into its unique lifecycle and cell division. buff.ly/FcDzAY4
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David Bikard @dbikard.bsky.social · 11/10/2025
Entretien pour Brut sur la vie Miroir, l'ingénierie génétique et l'éthique de ces recherches: www.brut.media/fr/videos/sc...
brut.media
Manipulations génétiques, virus créés par l’IA, bactéries miroirs : quelles limites à la recherche scientifique ?
Elles pourraient aider à lutter contre les cancers… mais aussi détruire toute trace de vie sur Terre ! Ce sont les bactéries miroirs. En avez-vous déjà entendu parler ? Et la vie miroir, ça vous dit q...
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FEMS Journals @femsjournals.bsky.social · 08/10/2025
A new subgroup of #CRISPR-associated transposons, V-K_V2, has been discovered in Nostocales #cyanobacteria by @cyanolab.bsky.social & colleagues 🧬. Its unique features suggest genetic mobility and V2 tracrRNAs are now included in the updated CRISPRtracrRNA tool. buff.ly/gioIfEB
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FEMS Journals @femsjournals.bsky.social · 04/10/2025
Some #Pseudomonas aeruginosa strains naturally lack the major virulence system T3SS. 🦠 @inaattree.bsky.social & @cbuch.bsky.social labs reveal that avirulent isolates still produce valuable metabolites (e.g. rhamnolipids, elastase, pyoverdine)—making them promising for #biotech use. buff.ly/JST7ZR1
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FEMS Journals @femsjournals.bsky.social · 27/09/2025
Phages are promising against antibiotic-resistant bacteria—but resistance can emerge. 🦠 New work from @baerboletta.bsky.social lab shows E. coli can resist phages in the lab, but in the gut that resistance comes at a cost: context is crucial for #PhageTherapy success. buff.ly/NLOjnE2
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Jeunes microbiologistes de la SFM @jm-sfm.bsky.social · 24/09/2025
Cyril Anjou, 2e candidat au prix de thèse nous a présenté ses travaux sur les rôles physiologiques des systèmes thioredoxine de Clostridioides difficile, impliqués dans les étapes du cycle de vie de la bactérie, ainsi que sur l’intérêt thérapeutique potentiel de la modulation de leur expression.🦠
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Enninga Lab @enningalab.bsky.social · 18/09/2025
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫 Thread coming soon!
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FEMS Journals @femsjournals.bsky.social · 18/09/2025
New tool alert! 🚀 MCAAT uses de Bruijn graphs to detect #CRISPR arrays in #metagenomes, capturing data lost in assemblies. A step forward in uncovering the hidden diversity of CRISPR-Cas systems. By Talibli & Voß buff.ly/QMX9yIe
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FEMS Journals @femsjournals.bsky.social · 15/09/2025
Archaea thrive in harsh niches that challenge DNA integrity. 🧬 In H. volcanii, Sailer et al. revealed Cas1 & Hel308a as new Microhomology-Mediated End Joining (MMEJ) players, expanding the toolkit for archaeal genomes repair. buff.ly/lnyY7JF
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Benoit Pons @benoitjpons.bsky.social · 04/09/2025
How do bacteria choose what type of defences to use against phages? We explored that question in the last paper I worked on as a postdoc at the Uni of Exeter @uniofexeteresi.bsky.social with Stineke van Houte, Stefano Pagliara and Edze Westra (not on Bluesky) doi.org/10.1098/rstb...
doi.org
Phage provoke growth delays and SOS response induction despite CRISPR-Cas protection | Philosophical Transactions of the Royal Society B: Biological Sciences
Bacteria evolve resistance against their phage foes with a wide range of resistance strategies whose costs and benefits depend on the level of protection they confer and on the costs for maintainance....
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Julie Le Bris @julielebris.bsky.social · 10/09/2025
How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes? That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus. The paper: www.biorxiv.org/content/10.1... Thread👇
biorxiv.org
Serotype swapping in Klebsiella spp. by plug-and-play
Understanding how complex, multi-gene systems evolve and function across genetic backgrounds is a central question in molecular evolution. While such systems often impose costs through epistatic inter...
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Olaya Rendueles @olayarendueles.bsky.social · 09/09/2025
Check out @julielebris.bsky.social’s thread on our latest manuscript describing phenotypic heterogeneity in capsule production in Klebsiella & Acinetobacter @klebclub.bsky.social This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social #microsky #phagesky
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Julie Le Bris @julielebris.bsky.social · 05/09/2025
Delighted to share our recently published work! Ever wondered how Klebsiella (and others) deals with capsule production’s costs ? The paper: journals.asm.org/doi/10.1128/... Thread👇
journals.asm.org
Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio
The polysaccharidic capsule is present in ~50% of species across the bacterial phylogeny, including all ESKAPE microorganisms, the six most significant multidrug-resistant (MDR) nosocomial pathogens. It is also an important virulence factor and a major ...
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FEMS Journals @femsjournals.bsky.social · 27/08/2025
#CRISPR is more than Cas9 ✂️ 🧬 @BeiselLab reveals a short tracrRNA from S. pyogenes is toxic in L. paracasei, even without Cas9, underscoring challenges of using CRISPR-Cas9 in non-native hosts. #microsky buff.ly/qWjkxdK
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Anne Chevallereau @annechevallereau.bsky.social · 19/08/2025
#phagesky I am looking for phages infecting Streptococcus pneumoniae to test a phenotype - does anyone have some and willing to share ? Repost appreciated :)
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Olaya Rendueles @olayarendueles.bsky.social · 18/08/2025
Looking forward to #ESEB2025 Day 1! In this meeting, the team has two talks: I’ll present coevolutionary dynamics between bacteria & their prophages in S43 Tuesday PM & @julielebris.bsky.social will speak on Thursday AM, S34, on phenotypic heterogeneity of capsule expression.
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FEMS Journals @femsjournals.bsky.social · 13/08/2025
🔬 We’re past the midpoint of the year; perfect time to look back at what’s been discovered so far. From how Salmonella slows its escape from immune cells to the microbes thriving in oil reservoirs, these are the most-read #microLife papers of 2025 so far: buff.ly/TfhOvEc
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Olaya Rendueles @olayarendueles.bsky.social · 01/08/2025
Manuscript accepted just in time for #ESEB2025 @eseb2025.bsky.social @julielebris.bsky.social will present phenotypic heterogeneity in some #ESKAPE pathogens 🧫 ! S34.01 - Mechanisms of adaptation to changing conditions in microorganisms Those not going to Barcelona, stay tuned for details!
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FEMS Journals @femsjournals.bsky.social · 31/07/2025
🌍 Health isn’t just about medicine. #WHO’s Health in All Policies (HiAP) shows every sector—transport, housing, economy—shapes our health. 🏙️ Since all human activity impacts the microbiosphere—life’s foundation—HiAP must go #microbial. 🧫 🔬 Read the editorial by K.Timmis & colleagues: buff.ly/pcOjL6h
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FEMS Journals @femsjournals.bsky.social · 24/07/2025
#Actinomycetes are rich in #CRISPR-Cas systems—many with unique features—yet their roles remain largely unknown.🧬 Mitousis et al. review highlights the need to explore these systems to unlock better genetic tools & new #naturalproducts.🦠 ⚙️ @unituebingen.bsky.social buff.ly/84sehNp
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