Every day, there are almost 800 new cases of childhood cancer around the world. This adds up to an estimated 300,000 new cases of cancer that affect children under the age of 20 each year worldwide. A...

Theory can help address cell and molecular biology’s major challenges, particularly those arising from large omics datasets.

Biayna, Baranovskii and colleagues report that intron-retained RNAs derived from cell cycle- and genome maintenance-related genes are pooled at the periphery of nuclear speckles and undergo synchronou...

Intercellular mRNA transfer between mammalian cells in vitro occurs via tunneling nanotubes to express functional proteins upon translation that complement genetic mutation. Complementation via RNA tr...

In this Perspective, Haubrock et al. argue that today’s scientific structures constrain creativity and that strategic conformity is a rational response. They discuss how this holds back early-career r...

Inflammation induces interchromosomal DNA interactions that bring parent genes into close proximity, facilitating the formation of chimeric mRNAs that encode physiologically relevant, functional prote...

Led by Northwestern Engineering’s Vadim Backman, the multi-institutional Science and Technology Center will integrate experts in physics, biology, engineering, AI, and medicine to understand how the g...

Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...

Popular vendors’ catalogs feature more than 18,000 manipulated images

A non-profit creating and applying tools to characterize the molecules and wiring of the human brain, as well as to interpret how they contribute to brain functions and dysfunctions, openly sharing to...

Transcription factors (TFs) are central to gene regulation and play critical roles in development, cellular homeostasis and disease. The ability to accurately measure TF activity is essential to under...

Super-enhancers have been proposed to cluster in the nucleus when compared to other genomic elements. Le et al. found that super-enhancer clustering was rare and driven by non-specific interactions. P...

Learn about new NSF funding opportunities prioritizing foundational research across the sciences and engineering.

Professor Vadim Backman’s group showed that changing the nucleus’s ionic environment can rapidly reshape chromatin and alter how cancer cells respond to chemotherapy.

Large-scale chromatin compaction quantitatively predicts the percentage of cells with durable epigenetic memory of gene silencing.

Landmark project that solved protein folding gives way to a wider race to build AI systems for scientific discovery

Elimination of all spliceosomal introns reveals a spliceosome-independent eukaryote.

The 3D organisation of chromatin inside a human cell is still not fully resolved. Here the authors reveal that in situ cryo-ET resolves individual nucleosomes and predicts DNA linkers, thus showing th...

Direct validation of the nanoscale structural organization of membrane proteins requires localization precision that matches their molecular dimensions. The sodium-potassium pump, or the Na,K-ATPase i...

Enhancers activate specific target promoters, but whether intrinsic enhancer-promoter compatibility contributes to this specificity is debated. Recent studies using different reporter assays have reac...

Abstract. Chromatin has a complex 3D structure and diverse binding proteins that coordinate the genome’s most essential functions. Many microscopy and geno