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Kyle MacQuarrie MD PhD

@kylemacquarrie.bsky.social
3.5K followers 777 following 861 posts

Pediatric oncologist and physician-scientist in Chicago, Asst Prof, big ol’ science nerd, 🏳️‍🌈, views my own, etc etc

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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 28/09/2026
It’s the last days of Childhood Cancer Awareness Month, and our fundraising with Alex’s Lemonade Stand Foundation will soon be coming to an end. Anything from donations, to reposts, to supporting another peds cancer effort is much appreciated! www.alexslemonade.org/2026/macquar...
alexslemonade.org
MacQuarrie Lab
Every day, there are almost 800 new cases of childhood cancer around the world. This adds up to an estimated 300,000 new cases of cancer that affect children under the age of 20 each year worldwide. A...
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 26/09/2026
There are worse places to do some work on the weekend.
A dog, a deck, some plants, and a real nice day, all around me while I do some work on my laptop.
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 20/09/2026
TFW your trip home goes from JFK -> ORD to JFK -> Cleveland -> ORD to JFK -> Cleveland (delayed x2) -> ORD to JFK -> Rochester NY (inflight diversion) to JFK -> Rochester Holiday Inn (x9 hours) to RCH (+1 day) -> ORD to RCH (+1 day) -> ORD (delay x1).
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 19/09/2026
I guess I do science with the deer and in the woods now. (Partially because my flight home got cancelled literally as I posted this.)
Me, in front of a field and woods.A deer that is really very close to me
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 17/09/2026
100% more deer content at this meeting at Cold Spring Harbor than any other scientific meeting I’ve been to.
A deer at a close distance to me.
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 15/09/2026
The views at Cold Spring Harbor Lab meetings just never miss. @cshlmeetings.bsky.social
One gorgeous view of a field and treesA second gorgeous view of a field and trees.
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 09/09/2026
Got to show up on FOX32 Chicago on Labor Day to talk about Childhood Cancer Awareness Month, how important it is to support pediatric cancer patients and families, and a little about my work. Unknowingly coordinating my tie with the anchor’s outfit was just an added bonus.
Me, smiling in a green room with the ‘FOX32 Chicago’ sign on the wall behind.A picture of a tv screen showing myself and a FOX32 anchor, Tia Ewing, talking on set about Childhood Cancer Awareness Month.
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 03/09/2026
Too many writing tasks to get through? Do what I (accidentally) did and write the list somewhere where visitors to your office will lean against the wall and unknowingly erase them for you. Problem solved. Follow me for more efficiency tips!
A list labeled ‘writing tasks’ on a wall that has had all the items smudged out.
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 02/09/2026
It’s Childhood Cancer Awareness Month, and we’re taking part in Alex’s Lemonade Million Mile Fundraiser. Please consider supporting pediatric cancer patients, families, and research this month! www.alexslemonade.org/2026/macquar...
alexslemonade.org
MacQuarrie Lab
Every day, there are almost 800 new cases of childhood cancer around the world. This adds up to an estimated 300,000 new cases of cancer that affect children under the age of 20 each year worldwide. A...
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 29/08/2026
*Very* excited to say that I and my lab are part of GENIE!
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Reposted by Kyle MacQuarrie MD PhD
@PhysGenCenter @physgencenter.bsky.social · 14/08/2026
Just published in Advanced Science: "Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States" "We may soon be able to engineer chromatin packing states to influence cell function” postdoctoral fellow Cody Dunton said. www.mccormick.northwestern.edu/news/article...
mccormick.northwestern.edu
Study Reveals New Way Cells Organize Their Genomes
Professor Vadim Backman’s group showed that changing the nucleus’s ionic environment can rapidly reshape chromatin and alter how cancer cells respond to chemotherapy.
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Microplastics Sommelier @leastactionhero.bsky.social · 25/08/2026
RIP to a legend
rob dubbin @robdubbin

MY MAN: (comes home)
ME: (nervous) how was the store
MY MAN: fine
ME: oh thank g-
MY MAN: ran into jolene
ME: oh no
MY MAN: she mentioned you left kind of an intense voicemail

12:50 AM • Jul 29, 2019
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Phil Lewis @phillewis.bsky.social · 25/08/2026
Two people have died in Pennsylvania from measles, the state health department said. Both were unvaccinated. These the first deaths related to measles within the state in 35 years, it reports
abcnews.com
2 people die from measles in Pennsylvania
Two people have died in Pennsylvania from measles, the state health department said Tuesday.
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 24/08/2026
Now that I know ‘expensive tastes’ is a keyword you can use, all my papers with pricey sequencing library prep are getting labeled this.
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Reposted by Kyle MacQuarrie MD PhD
Med - a Cell Press journal @cp-med.bsky.social · 21/08/2026
Online Now: Melanoma to rhabdomyosarcoma plasticity in the setting of immunotherapy
dlvr.it
Melanoma to rhabdomyosarcoma plasticity in the setting of immunotherapy
Knight et al. present the first molecularly validated case of metastatic melanoma that divergently evolved into rhabdomyosarcoma under treatment with immune checkpoint inhibitor. Longitudinal multiomic profiling revealed that this divergence was characterized by transcriptional changes rather than genetic mutations, providing insights into the mechanisms of lineage plasticity.
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 20/08/2026
You’re right, LinkedIn, I *haven’t* calculated the cost per wear of putting my lab members into these uniforms to do science. 🤔🤔 (And I guess waiters don’t exist?)
A LinkedIn ad for ‘waitressville’ uniforms.
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Reposted by Kyle MacQuarrie MD PhD
NEJM.org @nejm.org · 19/08/2026
In a child with advanced nephroblastoma, T-cell therapy targeting preferentially expressed antigen in melanoma led to a 69% tumor reduction, with molecular, metabolic, and histologic evidence of complete remission at 200 days. Full case details: nej.md/3U8jVl2
A graph showing the change in the diameter of respective target lesions measured according to Response Evaluation Criteria in Solid Tumors, version 1.1, which documents pseudoprogression in liver metastases.
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 16/08/2026
When life gives you lemons (a 4 lb bag of plums from Costco), make lemonade (a plum upside-down cake).
A plum upside down cake on a plate.A slice of plum upside down cake
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 13/08/2026
My assistant for tonight’s final grant edits has assumed the appropriate vantage point to monitor my progress.
A corgi curled up in a chair in an office, watching me closely.
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Harmit Singh Malik @harmitmalik.bsky.social · 12/08/2026
Amid the rush to burn DEI infrastructure to the ground, it’s worth remembering that the goal was never favoritism. It was a fair shot for people long excluded by unconscious or real bias — prominent scientists, including Nobel laureates, openly argued some “races” were innately unsuited for science.
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Seth Trueger @mdaware.org · 05/08/2026
in addition to the ablism, it's false reassurance -- nearly half of adults have hypertension, a lot have diabetes or high cholesterol, 7% are immunocompromised… people we encounter in our daily lives all the time we think of as healthy take BP meds, cholesterol meds, take mAbs for IBD…
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Stephen Nuñez @socio-steve.bsky.social · 03/08/2026
Not a big fan of the "sick, elderly and/or disabled people don't count" discourse that appears to follow public health disasters these days.
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 28/07/2026
This is exceptionally cool transcriptional biology (and science in general).
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 27/07/2026
Not my area of expertise, but it’s probably bad when water is shooting UP from drains during a downpour?
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 20/07/2026
Devastating office pineapple plant update - it toppled over sometime during the weekend and now looks sort of drunk when I flipped it back upright. I suspect its remaining days are numbered. 🫡
The pineapple plant in my office with its pineapple upside down and hanging on for dear life.A severely askew pineapple on a pineapple plant (after I pushed it back into place).
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Reposted by Kyle MacQuarrie MD PhD
Costa Samaras @costasamaras.com · 19/07/2026
Could Excel be conscious? We surveyed more than Jan 1 1900 people to find out.
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Maggie Astor @maggieastor.bsky.social · 08/07/2026
One minute these babies are fine. The next they're seizing, or vomiting blood, or not waking from a nap, or not breathing. I spoke with more than a dozen doctors who have seen the consequences of more parents declining the routine vitamin K shot for their newborns. This is what it looks like.
nytimes.com
As Parents Reject Vitamin K Shots, Some Babies Develop Devastating Bleeding
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 08/07/2026
On today’s episode of Adventures in Berry Farming - about $15 worth of raspberries if they were from the store and with a bonus of getting a bunch of stabs from thorns while picking em.
A Tupperware container of freshly harvested raspberries from my yard
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 01/07/2026
Just gonna say my Chicago-based office has been tropical way before it got trendy here.
A screenshot of a news article mentioning Chicago is currently more humid than the Amazon rainforest.The pineapple plant in my office is happy as a clam and continuing to grow.
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Reposted by Kyle MacQuarrie MD PhD
Harmit Singh Malik @harmitmalik.bsky.social · 24/06/2026
I know it seems like a heretical idea, but one way to figure out if a preprint is really interesting (to you) is... to read the preprint. Then, in the spirit of sharing, send a note to authors: a simple kudos or a more detailed question. I do this a dozen times a year. It's awesome. Try it.
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 24/06/2026
I’ve been pretty sure autocorrect has gotten worse, but this is a whole new level.
My phones autocorrect suggesting that I want to type ‘edicruok’ or ‘edu dupl’ in response to me leaving the ‘a’ out from the word ‘education’, but otherwise spelling it correctly.
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Reposted by Kyle MacQuarrie MD PhD
Grantham Research Institute at LSE @granthamlse.bsky.social · 23/06/2026
We regret that our event on Extreme Heat: Improving governance and strengthening action around the world has been cancelled due to the red extreme heat warning issued by the UK Met Office. Our apologies to everyone who was planning to attend the event.
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Reposted by Kyle MacQuarrie MD PhD
APHA @apha.org · 22/06/2026
If OMB's proposed changes to the federal grant process are enacted, political appointees could: 1. Make funding decisions regardless of the advice of scientists. 2. Stop funding midway through a promised grant period. 3. Institute new rules, including rules severely limiting foreign interactions.
nejm.org
The OMB and the Politicization of Science | NEJM
The Editors highlight three aspects of OMB’s recently proposed rule changes as particularly striking: that decisions on research funding would be made by political appointees, that funding could be...
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 22/06/2026
Don’t mind me, just adding in a work deadline for the end of November 2028 to my calendar on a sunny summer Monday morning in 2026.
static.klipy.com
Dean Winchester's Exasperated Sigh
ALT: Dean Winchester's Exasperated Sigh
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 09/06/2026
We *were* wondering why our strawberry patch seemed slow to produce this year.
A raised strawberry bed with a rabbit sitting in the middle of it.
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 07/06/2026
I get the occasional gardening success.
A pruned rose that I somehow grew successfully.
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Reposted by Kyle MacQuarrie MD PhD
Colette Delawalla, PhD @cdelawalla.bsky.social · 05/06/2026
Members of the American Diabetes Association (ADA) were removed by police during the organization's annual meeting on Friday as they handed out copies of an editorial criticizing Trump administration changes to U.S. biomedical research. www.medpagetoday.com/special-repo...
medpagetoday.com
Video: Police Tussle With Diabetes Experts at ADA Meeting
Researchers told they could no longer attend the annual scientific sessions
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 02/06/2026
Celebrating the start of Pride in true physician-scientist fashion: working on a grant at home while also on call.
a platypus holding its head in horror in front of a flaming laptop with the word ‘cooked’ above it.
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Reposted by Kyle MacQuarrie MD PhD
Ben Hall @hallben.bsky.social · 29/05/2026
New preprint! Why does the timing of mutations during B-cell development matter for childhood #leukaemia? Using a new computational model of B-cell differentiation, we explain observations from BCP-ALL patient data and predict how it shapes #cancer evolution. www.biorxiv.org/content/10.6...
biorxiv.org
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Jeremy Berg @jeremymberg.bsky.social · 27/05/2026
I heard from several sources yesterday that NIH is planning to release a Request for Information (RFI) that apparently will include this: Scores and percentiles for NIH grant applications will not be shared with applicants although they will be provided to NIH program officers and staff. 1/3
static.klipy.com
Huh Kermit
ALT: Huh Kermit
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Benoit Bruneau @benoitbruneau.bsky.social · 26/05/2026
A UCSF colleague got a perfect 1. He won’t get it. Why? 1. He has nih funding already (not relevant). 2. Institute (can’t remember which) priorities have changed to more clinically relevant. 3. Geographical considerations.
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 24/05/2026
Today’s grant writing assistants.
A Vallhund asleep on the floor and a corgi asleep on my lap
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 23/05/2026
Someone in the news departments of @nature.com or @science.org needs to take a look at this--its a huge scandal from the scientific supplier that has become a monopoly
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Abraham Palmer @abepalmer.bsky.social · 15/05/2026
A colleague received bad news from her NIH program officer today: my colleague’s grant got a great score, but NIH still can’t pay it, and my colleague will have to closer her lab. The call ended with the program officer (not my colleague) crying. Awful on so many levels.
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Wallace Marshall @wallaceucsf.bsky.social · 14/05/2026
you've heard alot about how cells are or are not crowded at the molecular scale, but what about at the organelle scale? in her new preprint, @marymirvis.bsky.social develops a quantitative way to ask this question in budding yeast - see her thread below www.biorxiv.org/content/10.6...
biorxiv.org
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Elphege Nora Lab at UCSF @elphegenoralab.bsky.social · 13/05/2026
Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 12/05/2026
The face of a dog who does NOT APPRECIATE me taking out the trash to the bins without his help.
An indignant Vallhund seen through a fence
The Vallhund has become even more indignant and is seen closer up
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Kyle MacQuarrie MD PhD @kylemacquarrie.bsky.social · 10/05/2026
Look, I know the clover in our yard is good rabbit food but you’re flirting with danger here, buddy.
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