During EMT, PBRM1 targets PBAF to H3K14Ac sites, opening chromatin to activate TGFβ targets and enable breast cancer metastasis.

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This study uses single-molecule footprinting to quantify chromatin accessibility at enhancers and promoters in mouse embryonic stem cells and to dissect the contributions of transcription factor bindi...

The 2027 Gordon Research Conference on Epigenetics will be held in Holderness, New Hampshire. Apply today to reserve your spot.

The PR-DUB complex is responsible for erasing the repressive histone modification, H2AK119ub1. ASXL1-3 proteins are mutually exclusive catalytic partners of BAP1 in the PR-DUB complex. Somatic heteroz...

Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...

The kidney proximal tubule undergoes dramatic cell-state transformations during recovery from injury, serving as a unique model to study the dynamic t…

Tünnermann et al. use live-cell imaging to study promoter activity under the control of an enhancer inserted at different genomic distances. RNA production from the promoter occurs in clusters of tran...

This study uses a precise and efficient clustered regularly interspaced short palindromic repeats (CRISPR) prime editing system to substitute lysine residues in histone H3, individually or in combinat...

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Some report burning through their whole monthly "AI credit" allotment in a single day.

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Come to this beautiful Swedish inland scenario to learn the most advanced technologies to study transcriptional regulation.

Postdoctoral Scientist Salary £42,694 per annum pro rata Fixed term for 3 years MRC Laboratory of Molecular Biology, Cambridge, UK Applications are...