Epigenetic inheritance provides mutation-free mechanisms for phenotypic adaptation, including modifications to DNA or DNA-associated proteins that create patterns of heritable gene regulation. However...

Using rapid SPT5 depletion, Dulja et al. uncover different molecular phenotypes at different embryonic stages. In early embryos, SPT5 depletion shifts Pol II from the pausing site to the +1 nucleosome...

This passionate melodrama by Satyajit Ray, about four middle-class men on a heedless spree in a rural village, is a teeming panorama of social divisions and inequities.

Macroautophagy/autophagy is a process that degrades intracellular components and is strongly triggered by nitrogen starvation (-N). Some ATG (autophagy related) genes are activated at the transcriptio...

Nature Reviews Molecular Cell Biology, Published online: 30 July 2026; doi:10.1038/s41580-026-01003-wThis Review discusses how transcript elongation by RNA polymerase II is regulated and how obstacles such as nucleosomes are overcome. Also discussed are the roles of transcription surveillance machineries, which ensure mRNA integrity and suppress spurious transcription, and how elongation defects contribute to diseases.

Oct. 29 – Nov. 2, 2026 | Alexandria, VA

In eukaryotes, DNA is not a naked repository of genetic information but is tightly wound around histone octamers to form nucleosomes. While this packaging solves the spatial problem of fitting 2 mete...

Nature Structural & Molecular Biology, Published online: 03 July 2026; doi:10.1038/s41594-026-01836-1By integrating cryo-electron microscopy structural analysis with biochemical analysis, we demonstrate that an asymmetric non-canonical nucleosome, namely the overlapping dinucleosome, imposes directionality on transcription by RNA polymerase II. This finding demonstrates how non-canonical nucleosomes in the genome might regulate transcription.

Click the link provided to see the complete job description.

Poly (ADP-ribose) Polymerase 1 (PARP1) is an abundant nuclear enzyme that dynamically engages chromatin in diverse cellular scenarios. In the context of DNA repair, PARP1 becomes enzymatically activat...

YouTube video by the bumbling biochemist

Centromeric DNA repeat insertions and CENP-A chromatin assembly are identified as genomic signatures that preserve telomere integrity in ALT cancer cells.

YouTube video by the bumbling biochemist