iiinova — where your digital self keeps evolving

Reposted by francette-lab.social

Nature Portfolio @natureportfolio.nature.com · 03/08/2026

Correction! It's from Nature Medicine, not Nature Communications.

francette-lab.social @transcribe-or-die.bsky.social · 23/07/2026

Knowledge is power and whether you are a pro-, anti-, or have complicated feelings about AI (<- this one), I think it is impossible to ignore it. I want to share a few youtube channels that I feel do a good job of making the risks and/or advancements in AIs approachable.

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francette-lab.social @transcribe-or-die.bsky.social · 30/06/2026

I love that it is so easy now to just build an application to solve whatever problem you have. Just made it so I can pull a bioRxiv DOI and parse the text/images/etc into a split-view to make reading just a little easier. Mostly inspired by the eLife "side-by-side" article view (which I love).

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Reposted by francette-lab.social

Genetics Society of America @genetics-gsa.bsky.social · 29/06/2026

New from @faseborg.bsky.social: a free tool to respond to the proposed OMB rule. ✅ 1-minute, 6-question assessment ✅ Personalized impact analysis ✅ Customizable draft comment letter for submission. 🔗Check it out: buff.ly/iyCXcy5

buff.ly

Defend Research

We advance health and well-being by promoting research and education in biological and biomedical sciences through collaborative advocacy and service to our societies and their members.

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francette-lab.social @transcribe-or-die.bsky.social · 23/06/2026

Falling down the rabbit hole of Bayes-factors vs p-values. It definitely feels a little more rigorous to use BFs! I want to better understand the appropriate standards for practice before committing to go full-Bayes, but I am getting increasingly convinced. doi.org/10.1016/j.to...

doi.org

Redirecting

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francette-lab.social @transcribe-or-die.bsky.social · 22/06/2026

The subject of moonlighting/specializing proteins is always fascinating, but complicated. This review from Verger et al. discusses this concept with respect to Mediator doi.org/10.1042/BST2..., and I started to think about this in context of the PAF1 Complex.

doi.org

Non-canonical subunit functions in multiprotein complexes: insights from the Mediator complex

Abstract. The Mediator complex is a central regulator of RNA polymerase II transcription, integrating signals from transcription factors and coordinating pre-initiation complex assembly. Beyond this c...

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Reposted by francette-lab.social

Seychelle Vos @voslab.org · 29/05/2026

⚡New preprint from the lab⚡: A key early checkpoint in gene expression is promoter proximal pausing of RNA polymerase II. For over 20 years, we as field have not been able to recreate pausing under realistic cellular conditions. @robertovn.bsky.social shows that ELOF1 is the missing piece.

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Reposted by francette-lab.social

PLOS Biology @plosbiology.org · 16/06/2026

How has #evolution shaped Transcription Elongation Factors, important for #GeneExpression? This study by Alex Francette, Karen Arndt &co traces ten core factors to the last eukaryotic common ancestor, and shows they display both conserved and lineage-specific domains. 🧪#AcademicSky plos.io/4eaCUTJ

The authors' proposed model reflecting the acquisition and putative loss of transcription elongation factor domains across clades in the Tree of Life

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Reposted by francette-lab.social

Reese Richardson @reeserichardson.bsky.social · 05/06/2026

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)

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francette-lab.social @transcribe-or-die.bsky.social · 16/06/2026

Thought it was finally time to start up my Lab's BlueSky account! I still feel a bit of awe in even being able to say "my Lab". It is such an honor, privilege, and responsibility to be able to pursue an independent research program immediately after my Ph.D. Hope to stay active on BSKY!

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