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Sarah Hainer

@hainerlab.bsky.social
931 followers 348 following 76 posts

Associate Prof @PittBioSci studying transcription dynamics and chromatin biology | passionate about equity in STEM | she/her

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Sarah Hainer @hainerlab.bsky.social · 25/08/2026
Precisely 20 years after Takahashi and Yamanaka reported fibroblast reprogramming with OSKM to iPSCs, we are excited to invite articles to our BMC Biology collection. Please see our short editorial here: link.springer.com/article/10.1... And submit your amazing work to this celebratory collection!
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Caitlyn Cardetti, PhD @caitlyncardetti.bsky.social · 10/08/2026
📢 Call for papers - Pluripotency, differentiation, and reprogramming 📢 #BMCBiology Guest Editors: Sekyu Choi, Pohang Ge Guo, Exeter @hainerlab.bsky.social Masaki Kinoshita, Nottingham @stanleystrawbridge.bsky.social Chengchen Zha, Westlake Fan Zhou, Tsinghua link.springer.com/collections/...
link.springer.com
Pluripotency, differentiation, and reprogramming
BMC Biology invites submissions to our Collection on Pluripotency, differentiation, and reprogramming. This Collection highlights the molecular and cellular ...
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Sarah Hainer @hainerlab.bsky.social · 17/07/2026
Hi friends! I am a guest editor for a new collection in BMC Biology called "Pluripotency, differentiation, and reprogramming" and we just opened for submissions. Looking for research articles and reviews, please reach out if you are interested. I'm excited for helping with this collection!
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Sarah Hainer @hainerlab.bsky.social · 13/07/2026
The talented @isa-ozdemir.bsky.social wrote a review of CHD remodelers, discussing all 9 family members and their roles in ES cells and early development. dx.doi.org/10.1002/bies... 1/2
dx.doi.org
Molecular Acrobats: How CHD Remodelers Shape the Genetic Playground to License Cell Identity
In eukaryotes, DNA is not a naked repository of genetic information but is tightly wound around histone octamers to form nucleosomes. While this packaging solves the spatial problem of fitting 2 mete...
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PLOS Biology @plosbiology.org · 16/06/2026
How has #evolution shaped Transcription Elongation Factors, important for #GeneExpression? This study by Alex Francette, Karen Arndt &co traces ten core factors to the last eukaryotic common ancestor, and shows they display both conserved and lineage-specific domains. 🧪#AcademicSky plos.io/4eaCUTJ
The authors' proposed model reflecting the acquisition and putative loss of transcription elongation factor domains across clades in the Tree of Life
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Genetics Society of America @genetics-gsa.bsky.social · 27/04/2026
New in #GENETICS from @hainerlab.bsky.social: The nucleosome remodelers esBAF and INO80 selectively influence subcompartment identity and enhancer–promoter communication at key regulatory loci during higher-order chromatin organization in mice. 🔗 buff.ly/0eU5xg0
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 02/05/2026
Great thread from an @nationalacademies.org award winner highlighting the current cowardice and capitulation of NAS, tech industry and the leaders of both to the demands of Trump that are destroying American science 🧪
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Craig Kaplan @triggerloop.bsky.social · 27/02/2026
Three @biorxivpreprint.bsky.social preprints on acute depletion of FACT in ES cells. First, from my colleague at Pitt Sarah Hainer's lab 1/ www.biorxiv.org/content/10.6...
biorxiv.org
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Sarah Hainer @hainerlab.bsky.social · 27/02/2026
Incredibly proud to share our new preprint, lead by the Incomparable Rithika Sankar. Here we temporally dissect the role of FACT in mES cells, finding that FACT loss drives progressive deterioration of chromatin architecture, leading to transcriptional collapse. www.biorxiv.org/content/10.6...
biorxiv.org
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Denis Duboule @denisduboule.bsky.social · 15/02/2026
Very sad news. Gail Martin (1944-2026) was a figure in developmental biology. She pioneered the field of ES cells. A great colleague, a friend and a lovely person.
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Crystal Rogers, PhD @rogerslabucd.bsky.social · 06/02/2026
Happy Black History Month! I am sharing a permanent and continuously updated list of inspiring Black scientists! Check it out! Huge thank you to the folks who gathered this info. Thank you to @drstarbird.bsky.social and the rest of the Index Committee! www.wiley.com/en-us/resear...
wiley.com
Index of Inspiring Black Scientists | Wiley
The Inspiring Black Scientists Index is a curated database celebrating diverse contributions to science. Join us in promoting education and collaboration.
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Sarah Hainer @hainerlab.bsky.social · 21/01/2026
Proud to be Canadian 🇨🇦 www.cbc.ca/news/politic...
cbc.ca
Read Mark Carney's full speech on middle powers navigating a rapidly changing world | CBC News
Read the full text of Prime Minister Mark Carney's speech about a shakeup of the global order and role of middle powers at the World Economic Forum in Davos, Switzerland.
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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 14/12/2025
* vaccines keep kids from dying * guns cause kids to die these are unassailable conclusions based on mountains of evidence it is a crying shame that politicians pretend otherwise, endangering our kids and everyone else’s
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Dr. Kat Napaaqtuk❄️ @napaaqtuk.bsky.social · 27/09/2025
Comment period ends on Monday for a proposed rule change that would terminate student visas after 4 years. It also puts limits on exchange visitors and reps of foreign media, and shortens the length of time at the end of the visa from 60 days to 30 days. www.federalregister.gov/documents/20...
federalregister.gov
Establishing a Fixed Time Period of Admission and an Extension of Stay Procedure for Nonimmigrant Academic Students, Exchange Visitors, and Representatives of Foreign Information Media
Unlike most nonimmigrant classifications, which are admitted for a fixed time period, aliens in the F (academic student), J (exchange visitor), and most I (representatives of foreign information media...
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Sarah Hainer @hainerlab.bsky.social · 18/09/2025
New preprint is up, led by former postdoc Braulio Bonilla. We know these remodelers regulate nucleosome positions and occupancy, but do they have a role in regulating higher order chromatin structure? We take a peek for BAF and INO80C. www.biorxiv.org/content/10.1...
biorxiv.org
esBAF and INO80C fine-tune subcompartments and differentially regulate enhancer-promoter interactions
The genome is compacted in the nucleus through a hierarchical chromatin organization, ranging from chromosome territories to compartments, topologically associating domains (TADs), and individual nucl...
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Lucas Farnung @lucas.farnunglab.com · 29/08/2025
🧬 Transcription elongation by RNA polymerase II relies on a web of elongation factors. Our new work shows how IWS1 acts as a modular scaffold to stabilize & stimulate elongation. Fantastic work by Della Syau! www.biorxiv.org/content/10.1...
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Sarah Hainer @hainerlab.bsky.social · 29/08/2025
Our collaborative paper with the Arndt lab is out today: doi.org/10.1093/nar/... (originally bioRxiv: www.biorxiv.org/content/10.1...). Here we asked the question of how CHD1 localizes to chromatin.
doi.org
A direct interaction between the Chd1 CHCT domain and Rtf1 controls Chd1 distribution and nucleosome positioning on active genes
Abstract. The nucleosome remodeler Chd1 is required for the re-establishment of nucleosome positioning in the wake of transcription elongation by RNA Polym
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Karolin Luger @nucleosomepolice.bsky.social · 26/07/2025
if i were a better person i would do a tweetorial on our recent paper - but, hey, read the paper. its right there, waiting for you. #Giantvirus #histones are cool! their #nucleosomes are cool. check it out.! thats the tweetorial. rdcu.be/exXBX
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James Olzmann @olzmannlab.bsky.social · 21/08/2025
Tenure track position alert! Assistant Professor of Molecular Therapeutics in MCB @UCBerkeley. Apply and come be our colleague! 🎉 aprecruit.berkeley.edu/JPF05098
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Joanne Flynn @joanneflynn19.bsky.social · 20/08/2025
We are hiring! The Dept of Microbiology and Molecular Genetics is looking for faculty at the Assistant or Associate professor level (tenure track). Please consider joining our vibrant microbiology and immunology community at the University of Pittsburgh School of medicine
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Oregon State University Botany and Plant Pathology @osubpp.bsky.social · 06/08/2025
The successful candidate will oversee the management and direction of the OSU Herbarium and establish an independent research program by conducting original research in an area of plant systematics, ecology, and/or evolution.
jobs.oregonstate.edu
Assistant/Associate/Full Professor (Botany & Plant Pathology)
The Department of Botany and Plant Pathology invites applications for a full-time (1.00 FTE), 9-month, tenure-track or tenured Assistant, Associate, or Full Professor position.Any hiring at the rank o...
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Democracy Forward @democracyforward.org · 29/04/2025
We built a team to represent a coalition of unions, non-profits, & local governments in the largest lawsuit challenging Trump’s authority to remake the government without congressional approval. Trump's efforts to dismantle the federal government are unconstitutional and we will see him in court.
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Abby Thurm @abbythurm.bsky.social · 28/04/2025
Interested in synthetic approaches to both understand and manipulate gene expression? We (the Bintu lab) wrote a review that discusses just that - how modern low- and high-throughput approaches can dissect gene regulation at the DNA, RNA, and protein level. www.annualreviews.org/content/jour...
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Jeremy Berg @jeremymberg.bsky.social · 24/04/2025
ATTENTION: NSF GRANT RECIPIENTS We received a heads up from a trusted source that you should proactively download/print/screen shot any documentation on research.gov pertaining to your NSF awards, both those that are current and any that have closed in the last 5-6 years. 1/n
media.tenor.com
a cartoon of a man holding a frying pan and a spoon with red alert written above him
ALT: a cartoon of a man holding a frying pan and a spoon with red alert written above him
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Carmelo Ferrai @carmeloferrai.bsky.social · 13/03/2025
Profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&Tag Nadiya Khyzha ∙ Kami Ahmad∙ Steven Henikoff www.cell.com/molecular-ce...
cell.com
Profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&Tag
Khyzha et al. developed SLAM-RT&Tag, a kinetic labeling strategy for profiling RNA dynamics within nuclear compartments. Applied to Polycomb domains and nuclear speckles, they identified compartment-s...
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LauberthLab @lauberthlab.bsky.social · 12/03/2025
Join us at the 2025 Epigenetics Society International Conference in Chicago! Discover the latest in DNA, RNA, and chromatin epigenetics, steps from Navy Pier & Michigan Ave! www.esconference25.com. #Epigenetics2025 #DNA #RNA #Chromatin #ScientificConference #Chicago
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Sherry Pagoto, PhD @drsherrypagoto.bsky.social · 12/03/2025
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024. That's not to mention the countless lives that biomedical research has saved. Show me a better investment than that. www.forbes.com/sites/michae...
forbes.com
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
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Richard Sever @richardsever.bsky.social · 11/03/2025
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n
openrxiv.org
Homepage - openRxiv
openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.
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Jackson Hoffman @jxhoffman.bsky.social · 26/01/2025
First @fnucleosome.bsky.social talks of the year coming up on Wednesday! Register to join us And, if you're interested in presenting with us this year, you can fill out this survey: docs.google.com/forms/d/e/1F...
docs.google.com
Application to speak in the Fragile Nucleosome series
Thank you for your interest in our seminar series! We use a variety of different session formats but, in general, trainees can plan for a ~15 min talk + 5min Q/A and PIs can plan for a ~25min talk +...
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Ben Martin @benjaminmartin.bsky.social · 27/01/2025
In case you missed them, a number of our @fnucleosome.bsky.social talks from 2024 are now up on our youtube channel! Check out the recently uploaded seminars below: Julia Rogers: Notch induces transcription by stimulating release of paused RNA Pol II www.youtube.com/watch?v=GME2...
youtube.com
Julia Rogers
YouTube video by Fragile Nucleosome
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Surfin' NuRD @surfinnurd.bsky.social · 09/01/2025
PhD studentship! Chromatin! Structural Biology! Signaling! Stem Cells! Beautiful Devon! Honestly, what more could you want? APPLY NOW! Deadline Friday 10 Jan! @lsiexeter.bsky.social
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Sarah Hainer @hainerlab.bsky.social · 01/01/2025
Happy New Year from us to you!
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Sarah Hainer @hainerlab.bsky.social · 10/12/2024
Happy to share the latest preprint which is a close collaboration with Karen Arndt with a shared PhD student, Sarah Tripplehorn. Here we show a direct interaction between Chd1 and Paf1C subunit Rtf1 required for nucleosome positioning across genes: t.co/E9FSj2nHv8
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Sarah Hainer @hainerlab.bsky.social · 07/12/2024
Happy to share work with my close colleague Karen Arndt through a joint PhD student. Here we explored how Chd1 localizes across gene bodies, following up from previous Arndt lab studies identifying Rtf1 as require for Chd1 localization.
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Sarah Hainer @hainerlab.bsky.social · 18/11/2024
What an amazing time! Students at #ABRCMS2024 were so impressive! Incredibly proud of all the Pitt Biosci undergrads and grad students
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Sarah Hainer @hainerlab.bsky.social · 17/11/2024
I could not be more proud of these two amazing women: I told you to watch out for Kya Foxx last year: here she goes giving a talk and winning! And then introducing Bryona Jackson who you should be on the lookout for; just won a poster presentation award. #ABRCMS2024
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Sarah Hainer @hainerlab.bsky.social · 15/11/2024
Pitt BIOSC undergrads at #ABRCMS2024
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Sarah Hainer @hainerlab.bsky.social · 14/11/2024
Pitt Biosci grad students at #ABRCMS2024! So many amazing posters last night!
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Karim-Jean Armache @kjarmache.bsky.social · 13/11/2024
Please see our paper in Nature on read-write mechanisms of H2AK119 ubiquitination by Polycomb repressive complex I. Congrats to the whole team, especially Victoria and huge thanks to our collaborator JP Armache! Also big thanks to Mark Foundation for Cancer Research for the support! rdcu.be/dZ5HZ
rdcu.be
Read–write mechanisms of H2A ubiquitination by Polycomb repressive complex 1
Nature - Cryo-electron microscopy and biochemical studies elucidate the read–write mechanisms of non-canonical PRC1-containing RYBP in histone H2A lysine 119 monoubiquitination and their...
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Sarah Hainer @hainerlab.bsky.social · 13/11/2024
Kya Foxx checking her talk for Friday at 11:15am (CC-407) #ABRCMS2024 #proudmentor
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Sarah Hainer @hainerlab.bsky.social · 13/11/2024
We made it! See you at #ABRCMS2024!
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Sophien Kamoun @kamounlab.bsky.social · 04/03/2024
I just published: What’s a toxic environment for a PhD student? Being aware of potential red flags when selecting a host lab is crucial. Here are some issues I’ve witnessed over the years. #phdchat #AcademicChatter link.medium.com/O5fd2PQ0GHb
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Lydia Jennings, PhD @1nativesoilnerd.bsky.social · 04/03/2024
“Integrating cultural relevance into STEM education, promoting culturally responsive mentoring, engaging communities, and showcasing role models are all crucial strategies for empowering NA/AN students in their STEM pursuits.” www.openaccessgovernment.org/article/indi...
openaccessgovernment.org
Indigenous students face disparities in STEM
Dr. Judith Brown Clarke and Dr. Wendy K’ah Skaahluwaa Todd, shed light on the crucial role of cultural identity in native American-Alaskan students’ persistence and success in STEM fields and the Geos...
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Karolin Luger @nucleosomepolice.bsky.social · 04/03/2024
reviewing many grants and I will say that three letter acronyms are the WORST. why do I need to learn a new language for every grant? Folks, let me say this loud and clear: the space you gain by using TLAs is proportional to reviewer irritation. Use them sparingly. or NOT AT ALL! You are welcome
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Sarah Hainer @hainerlab.bsky.social · 01/01/2024
Happy New Year from us to you!
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Sarah Hainer @hainerlab.bsky.social · 19/11/2023
Incredibly proud of superstar Kya Foxx. Not only a full travel awardee but also a poster presentation award from #ABRCMS2023 - and this was her first poster presentation and first conference! Watch out science world! #proudmentor
Kya holding her certificate of award for poster presentationKya Foxx and Sarah Hainer smiling together
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Crystal Rogers, PhD @rogerslabucd.bsky.social · 30/10/2023
When I struggled to write a fundable grant back in 2020 and 2021, I applied for a JEDI award with LSEF and got it. I received the guidance I needed. If you are in a similar situation- please check it out! lifescienceeditors.org/apply/ youtu.be/lvguQrYgL1A?...
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Sarah Hainer @hainerlab.bsky.social · 22/10/2023
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Sarah Hainer @hainerlab.bsky.social · 22/10/2023
#NIH revises its research grant review process. For applications submitted on or after Jan. 25, 2025. go.nih.gov/9EROYa2
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