In eukaryotes, ribosome biogenesis initiates within the nucleolus, a hallmark multilayered compartment of the nucleus. Structures of pre-ribosomes have been characterized ex situ, but their assembly p...

The move came after the NIH director refused Trump’s request to cut Harvard grants in an Oval Office meeting.

The Trump administration’s deep cuts to health and public health and assaults on science-based policy are already being felt across the country—from Medicaid, research and staffing cuts to attacks on ...

ALT: Sesame Street's Cookie Monster: 'So Share It Maybe'

It’s far too early to declare a discovery, physicists with the LZ detector say

Authored by anonymous current and former NIH workers with experience in peer review

Letter to the Editor

A June 2026 Nature report revealed that mandatory reviews by top officials, checking for a list of 235 disfavored terms, have left hundreds of meritorious NIH applications in administrative limbo (Koz...

Proteome-wide prediction and structural modeling of disordered protein interaction interfaces advance characterization of disease-associated variants in disordered protein regions.

Brandon, Robinson-Thiewes, Kaulage et al. report that targeted BRD4 recruitment enables transcription through H3K9me3/HP1-marked heterochromatin without erasing repressive marks, identifying condensat...

Macroautophagy/autophagy is a process that degrades intracellular components and is strongly triggered by nitrogen starvation (-N). Some ATG (autophagy related) genes are activated at the transcriptio...

In Schizosaccharomyces pombe , the conserved CHD remodeler Mit1 function within the SHREC remodeler-deacetylase complex (a homolog of the metazoan Mi-2/NuRD complex), which is essential for H3K9 methy...

Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information: Proposal to Cap the Number of Simultaneous Research Project Grants per Principal Investigator ...

Instead of only addressing the core values of the peer review system (that must be retained or enhanced), as requested in the recent RFI from the NIH, I thought I’d highlight the core values …

I had reason this week to post data on the relative proportions of the NIH appropriation that are devoted to each Institute, in this case for the FY2025 appropriation. This came up in relationship …

A synthetic cell can now grow and divide—but it’s still far from alive

White House asserts expanded authority to prosecute any wasteful spending “in the national interest”

Abstract. Chromatin has a complex 3D structure and diverse binding proteins that coordinate the genome’s most essential functions. Many microscopy and geno

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ALT: Welcome Back Students - Zhivago1955