Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

Frogs have made significant contributions to Fred Hutch science over the years as a model organism that shares much of our biology, but they've been absent from the menagerie for about two decades. Dr...

Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

Nature Structural & Molecular Biology, Published online: 12 September 2025; doi:10.1038/s41594-025-01669-4The authors develop a computational method to design small DNA-binding proteins (DBPs) that target specific sequences. Designed DBPs show structural accuracy and function in both bacterial and mammalian cells for transcriptional regulation.

SARS-CoV-2 is under strong evolutionary selection to acquire mutations in its spike protein that reduce neutralization by human polyclonal antibodies. Here we use pseudovirus-based deep mutational sca...

Histone H3 cysteine 110 enhances iron metabolism and modulates replicative life span in yeast.

Tenthorey et al. compare the effects of missense and indel mutations on the acquisition of functional novelty by the rapidly evolving antiviral protein TRIM5α. They find that single indel mutations al...

Early embryos often have unique chromatin states prior to zygotic genome activation (ZGA). In Drosophila, ZGA occurs after 13 reductive nuclear divisions during which the nuclear to cytoplasmic (N/C) ...

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Legislative Mandates in Effect for FY 2024 NOT-OD-24-110. NIH

Specialized magnetic beads that bind target proteins to a cryogenic electron microscopy grid make it possible to study the structure of protein complexes from dilute samples.

We developed PRINT, a computational method that identifies footprints of DNA–protein interactions from bulk and single-cell chromatin accessibility data across multiple scales of protein size.

Why do authors choose the eLife Model? We spoke to Hironori Funabiki at the Rockefeller University to learn his reasons.

In situ cryo-electron tomography (cryo-ET) has emerged as the method of choice to investigate structures of biomolecules in their native context. However, challenges remain in the efficient production...

The 2024 Annual Report from the Basic Sciences Division at Fred Hutch features the divisions reflections for the year, as well as celebrations of faculty retiring and joining the division, events and...

This playlist contains six recordings covering single particle cryo-EM data processing in CryoSPARC from the 2024 Single-Particle Cryo-EM Image Processing Wo...

pSABER combines the power of signal amplification by exchange reaction (SABER) with the deposition of fluorescent or colorimetric substrates by horseradish peroxidase to enable enhanced signals for in...

By developing a long-read sequencing method to simultaneously map replication status and protein-DNA contacts in cells, Ostrowski, Yang, et al. show that newly replicated chromatin is enriched for unw...

Here, we introduce Magnetic Isolation and Concentration (MagIC)-cryo-EM, a technique enabling direct