Wickström discovered how cells sense the physical world around them. Her research showed that cells can “feel” forces such as pressure and stretching and relay these signals all the way to their DNA. ...

Single-nucleosome imaging/tracking and super-resolution three-dimensional structured illumination microscopy within euchromatic regions show that cohesin-mediated loops constrain condensed euchromatic...

Nature - Myb1 functions as a switch-like regulator of state transitions in Hortaea werneckii, whereby its expression and degradation are coupled to nutrient conditions, stabilizing unicellular or...

Cells in tissues need to know when to start growing and when to stop growing to quickly heal wounds but prevent tumorous overgrowth. Membrane potential allows cells to sense physical forces, including those from neighboring cells, and thereby regulates growth.

Enhancers are critical genetic elements controlling transcription from promoters, yet how they convey regulatory information across large genomic distances remains unclear. Here, we engineer pluripote...

Reconstituting 20-kb chromatin shows that tuning acetylation alone reshapes its folding, dynamics, and contact domain formation.

Reconstituting 20-kb chromatin shows that tuning acetylation alone reshapes its folding, dynamics, and contact domain formation.

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

Nature Communications - Cells can regulate their mass density. Here, the authors demonstrate how eukaryotes establish and maintain a lower density in the nucleus than in the cytoplasm via pressure...

Local chromatin motion remains steady during interphase, allowing cells to conduct housekeeping tasks under similar environments.

RAD21 contributes to nascent packing domain formation, but maturation requires nucleosome posttranslational modifications.