Nucleosome spacing influences higher-order chromatin fiber organization in vitro but how this relates to cellular chromosome structure remains contentious. To address this, we developed Ligation Analy...

Cryogenic electron tomography of condensed chromatin enables multiscale analysis of its structure

The cell’s ability to rapidly partition biomolecules into biomolecular condensates is linked to a diverse range of cellular functions. Understanding how the structural attributes of biomolecular conde...

Assistant/Associate Professor in Computational Biology in the Department of Applied Mathematics and Theoretical Physics at the University of Cambridge.

Mutations in certain protein regions have predictable effects on the stability of cellular droplets and the risk of harmful protein clumps forming inside them.

Biomolecular condensates composed of highly charged biomolecules, such as DNA, RNA, chromatin, and nucleic-acid binding proteins, are ubiquitous in the cell nucleus. The biophysical properties of thes...

Description of the project: During every cell cycle, our cells need to accurately copy their DNA and chromatin organization. This process is essential for life, and when faulty, it leads to diseases, ...

The Institut Pasteur, a research organization which for more than 130 years has been committed to tackling infectious diseases, sharing knowledge and defending science, has decided to leave X because ...

Torrino et al. identify the mechanosensitive polyol pathway as a natural mediator of cytoplasmic and nuclear protein condensates through tightly controlled intracellular sorbitol accumulation. Extrace...

Biomolecular condensates play key roles in the spatiotemporal regulation of cellular processes. Yet, the relationship between atomic features and condensate function remains poorly understood. We stud...

Cells must limit RNA-RNA interactions to avoid irreversible RNA entanglement. Cells may prevent deleterious RNA-RNA interactions by genome organization to avoid complementarity however, RNA viruses ge...

Subtle forms of misogyny attack female leadership and coerce women to conform to conventional gender norms. It’s time to call out these behaviours, say Alison Bentley and Rachael Garrett.