iiinova — where your digital self keeps evolving

Dave Shechner @shechnerlab.bsky.social · 02/09/2026

📄 Our latest review is now out in Current Opinion in Chemical Biology! We discuss a growing class of oligonucleotide-directed proximity labeling strategies that use programmable DNA hybridization to target RNAs and genomic loci. This was a fun one to write—I hope you enjoy it! bit.ly/4h6KaRV

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Dave Shechner @shechnerlab.bsky.social · 05/08/2026

🔥PREPRINT ALERT🔥 We often think of mitochondria as one interconnected network. But are all mitos the same? Our new preprint-a fantastic collaboration with @yasesancak.bsky.social -reveals that organelle contacts establish specialized mitochondrial populations. Check out Yasemin’s awesome thread 👇

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Dave Shechner @shechnerlab.bsky.social · 20/09/2025

AWESOME CONFERENCE ALERT!! I had an absolute blast at the Fusion “Genome Regulation Through RNA” meeting back in 2024, and psyched to see its upcoming return! Let’s geek out about all things Chromatin and RNA together, in Cancun! Talk abstract deadline: 10/17 Details👇

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Dave Shechner @shechnerlab.bsky.social · 02/08/2025

I’m a bit late to the game here, but wanted to highlight this very clever technique from @paraspeckle.bsky.social’s group! Congrats to all authors!!

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Dave Shechner @shechnerlab.bsky.social · 30/06/2025

Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit! tinyurl.com/ydn6e3ac

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Dave Shechner @shechnerlab.bsky.social · 14/03/2025

FUN FACT: In Europe, they celebrate #PiDay on the 3rd day of the 14th month.

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Dave Shechner @shechnerlab.bsky.social · 31/12/2024

TOP FIVE METABOLIC PATHWAYS …Based on whether they sound like the name of an old-school anime: 5. The Pentose-Phosphate Shunt 4. Peptidoglycan Degradation 3. Fatty Acid Beta-Oxidation 2. The Dark Reactions of the Calvin Cycle 1. Gluconeogenesis

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Dave Shechner @shechnerlab.bsky.social · 20/12/2024

Such awesome work from @nandangokhale.bsky.social, @ramlabuw.bsky.social, and colleagues! Fantastic seeing this paradigm-changing study out in the wild. Congrats, everyone!

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Dave Shechner @shechnerlab.bsky.social · 17/12/2024

Aw, yeah! It’s en-dash time, people!

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Dave Shechner @shechnerlab.bsky.social · 06/12/2024

Hallo! Does anyone have a robust protocol for coupling DNA oligos to proteins? The oligo will be fairly long, and so protocols that require lower mass inputs are preferred. We have free-rein over the oligo chemistry, but the protein is from a commercial source. Feel free to PM. Thanks in advance! 🙏

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Dave Shechner @shechnerlab.bsky.social · 05/12/2024

<Mind legitimately blown>. *Amazing* work from @aliceyting.bsky.social and colleagues, building programmable, synthetic GPCR’s. Congrats to all authors!!

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Dave Shechner @shechnerlab.bsky.social · 30/11/2024

Just updated my phone OS, and apparently the calendar doubles as a karyotype now?

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Dave Shechner @shechnerlab.bsky.social · 26/11/2024

In a world where you can be anything, be Reviewer #1.

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Dave Shechner @shechnerlab.bsky.social · 24/11/2024

Also, today I learned that the colloquial Turkish term for puberty is, “Delikanlık,” which literally translates to, “Crazy Blood-ness.” I assert once again that Turkish is the perfect language and none of you will be able to convince me otherwise.

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Dave Shechner @shechnerlab.bsky.social · 24/11/2024

It’s national Teachers’ Appreciation Day in Türkiye, and to all the Turkish teachers out there, Öğretmenler Günü Çok Kutlu olsun!!!

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Dave Shechner @shechnerlab.bsky.social · 21/11/2024

It's my great pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture. If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)

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Dave Shechner @shechnerlab.bsky.social · 15/11/2024

Woohooo! Fantastic seeing this out in print. Congrats to all the authors—it was an honor to play a small part in this exciting work!

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Dave Shechner @shechnerlab.bsky.social · 15/11/2024

This is an outrage, I tell you! AN OUTRAGE!!

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Dave Shechner @shechnerlab.bsky.social · 13/11/2024

Characteristically beautiful work from @jmtali.bsky.social and team!! A fine new addition to the growing barnyard of RNA-targeted proximity-labeling tools.

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Dave Shechner @shechnerlab.bsky.social · 13/11/2024

Meanwhile, basically my whole feed on the muskier platform:

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Dave Shechner @shechnerlab.bsky.social · 13/11/2024

Oh, why hello there! I was wondering where all the good folk of SciTwitter went. It’s fantastic seeing you all again.

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