A Junior Research Fellow at St Catharine's is part of an international team of scientists responsible for a long-awaited visualisation of liquid droplets forming inside a cell nucleus known as condensates, which help regulate essential processes such as gene expression, DNA repair and stress responses.

The structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo–electron tomography and molecular dynamics simulations, we elucidated the structur...

During cell division, chromosomes reorganise into compact bodies in which centromeres localise precisely at the chromatin surface to enable kinetochore-microtubule interactions essential for genome se...

Internucleosomal linker length alters the stability and dynamics of chromatin condensates by shifting the balance between inter- and intramolecular interactions. Further, by changing the linker length...

The cell’s ability to rapidly partition biomolecules into biomolecular condensates is linked to a diverse range of cellular functions. Understanding how the structural attributes of biomolecular conde...

Temperature influences nucleosome dynamics, and thus chromatin, to regulate gene expression. Such mechanisms underlie the epigenetic silencing of Arabidopsis FLOWERING LOCUS C (FLC) by prolonged cold....

Mutations in certain protein regions have predictable effects on the stability of cellular droplets and the risk of harmful protein clumps forming inside them.