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Kako Nakazato

@kakonakazato.bsky.social
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Reposted by Kako Nakazato
Kazuhiro Maeshima @kazu-maeshima.bsky.social · 26/09/2026
🧬 Highly related @natgenet.nature.com paper from @binzmit.bsky.social group, using nucleosome-resolution chromatin modeling: Euchromatin forms condensed domains with short active regions on the surface www.nature.com/articles/s41... Congratulations! 🎉
nature.com
Euchromatin forms condensed domains with short active regions on the surface - Nature Genetics
Simulations integrating micro-C and imaging data provide a coherent view of chromatin organization from nucleosomes to clutches to domains, revealing that most regions form compact domains but short r...
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Reposted by Kako Nakazato
Kazuhiro Maeshima @kazu-maeshima.bsky.social · 18/09/2026
🧬 Our “Behind the Paper” is now online at Nature Communities: “Active chromatin is not simply open—it forms compact domains that cohesin keeps from mixing.” 📖 A short story behind our recent @natgenet.nature.com paper. communities.springernature.com/posts/active... www.nature.com/articles/s41...
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Reposted by Kako Nakazato
Kazuhiro Maeshima @kazu-maeshima.bsky.social · 15/09/2026
How are mitotic chromosomes built? Our Review @cp-trendsgenetics.bsky.social revisits the classical chromosome scaffold model and connects it to condensins, topoIIα, and physical forces. We propose interphase chromatin domains as “building blocks”🧩of chromosomes: authors.elsevier.com/a/1nmwrcQbJI...
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Reposted by Kako Nakazato
Kazuhiro Maeshima @kazu-maeshima.bsky.social · 08/09/2026
Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @natgenet.nature.com reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗 www.nature.com/articles/s41... (1/2)
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Reposted by Kako Nakazato
Kazuhiro Maeshima @kazu-maeshima.bsky.social · 10/04/2026
Our linker histone H1 paper is featured on the cover of the April 10 issue of #ScienceAdvances. www.science.org/doi/10.1126/... A molecular dynamics simulation of nucleosomes and linker histone H1, with single-H1 trajectories (background). 🎉 Full cover caption: www.science.org/toc/sciadv/1...
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Reposted by Kako Nakazato
Kazuhiro Maeshima @kazu-maeshima.bsky.social · 07/07/2026
Our new preprint @biorxivpreprint.bsky.social, led by @katsuminami.bsky.social‬ et al.! 🎉 www.biorxiv.org/content/10.6... Machine learning-assisted Repli-Histo labeling and single-nucleosome imaging reveal distinct transcription-dependent chromatin constraints across euchromatin and heterochromatin.
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Reposted by Kako Nakazato
Kazuhiro Maeshima @kazu-maeshima.bsky.social · 18/06/2025
Our new review paper is out@JMB!🧬 @katsuminami.bsky.social‬ @semeigazin.bsky.social‬ ‪@kakonakazato.bsky.social‬ discuss DNA accessibility in euchromatin and heterochromatin of live cells. Free access: authors.elsevier.com/a/1lHgb54HFZ... Also check our previous work: www.science.org/doi/10.1126/...
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Reposted by Kako Nakazato
Kazuhiro Maeshima @kazu-maeshima.bsky.social · 29/03/2025
We quantitatively measured nucleosome motion across the 4 chromatin classes, from euchromatin to heterochromatin. 🧪 More euchromatic regions (i.e., earlier-replicated regions) show greater nucleosome motion. 🎉 Congrats @katsuminami.bsky.social @kakonakazato.bsky.social and all collaborators! 2/2
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Kazuhiro Maeshima @kazu-maeshima.bsky.social · 29/03/2025
Our new paper is out@ScienceAdvances👇 www.science.org/doi/10.1126/... 🧬Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live human cells. 🔍 @katsuminami.bsky.social et al. have developed a chromatin behavior atlas within the nucleus. 1/2
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Reposted by Kako Nakazato
Kazuhiro Maeshima @kazu-maeshima.bsky.social · 07/03/2025
Our new preprint is out@bioRxiv: www.biorxiv.org/content/10.1... @masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in living cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/
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