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Benedetta Bolognesi

@bennibolo.bsky.social
429 followers 530 following 29 posts

Biologist, Explorer. Group Leader @ibecbarcelona.eu‬ Protein Phase Transitions.

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Benedetta Bolognesi @bennibolo.bsky.social · 30/03/2026
Our latest paper is out! We built a large-scale mutational map of amylin to understand how sequence drives #amyloid formation, a process linked to type 2 #diabetes🩸📈📉. It’s a step towards connecting molecular mechanisms with human genetic variation in a systematic way.
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Benedetta Bolognesi @bennibolo.bsky.social · 05/03/2026
This time we went “functional.” 🙂 After years studying pathological amyloids, we followed RIPK1/3 into the other side of aggregation - where amyloids help cells decide when to die. 🔗🔗 🔗 www.biorxiv.org/content/10.6...
biorxiv.org
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Kalli Kappel @kallikappel.bsky.social · 17/06/2025
In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out! rdcu.be/eq975
rdcu.be
Characterizing protein sequence determinants of nuclear condensates by high-throughput pooled imaging with CondenSeq
Nature Methods - CondenSeq is an imaging-based, high-throughput platform for characterizing condensate formation within the nuclear environment, uncovering the protein sequence features that...
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Benedetta Bolognesi @bennibolo.bsky.social · 12/06/2025
New cocktail 🍹 in town - in collaboration with @benlehner.bsky.social : Massive combinatorial mutagenesis + amyloid kinetics selection + thermodynamic modelling showing us the portrait 🎨 of an amyloid transition state. Read about it in this great thread:
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Danielle Beckman @daniellebeckman.bsky.social · 05/06/2025
A black hole in the early universe? Sometimes I like to imagine that I operate a telescope, not a microscope 😁. The hole in the middle of the image is actually a blood vessel. The stars are astrocytes🟡 in the human brain, interacting with beta-amyloid🔵. The brain is from a donor with #Alzheimer.
Confocal microscopy photo
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Benedetta Bolognesi @bennibolo.bsky.social · 04/06/2025
Candle-lit commuting sponsored by @rodalies.info 🕯️🕯️🕯️
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John Burn-Murdoch @jburnmurdoch.ft.com · 04/06/2025
Full slide deck here from our talk yesterday on the gender divide and relationship recession, featuring many more countries and plenty of economic data too: www.dropbox.com/scl/fi/1lp1d...
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Ed Yong is offline @edyong209.bsky.social · 30/05/2025
I urge everyone to read Unbreaking’s new page on everything the govt is doing to destroy & diminish medical research funding. It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job. unbreaking.org/issues/medic...
unbreaking.org
Medical Research Funding — Unbreaking
How the administration is breaking the government, and what that means for all of us.
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Benedetta Bolognesi @bennibolo.bsky.social · 23/05/2025
And what a great talk to end #VariantEffect25 ! Thanks to the amazing crowd that travelled to Barcelona and made MSS25 such a fantastic meeting. Lots to think about now! 🧦🗺️☀️
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Benedetta Bolognesi @bennibolo.bsky.social · 22/05/2025
Fantastic talk #VariantEffect25 by @pollyfordyce.bsky.social on how much we can understand about sequence-function relationships once we are able to factor in kinetic 🏎️rates. Microfluidics 💧💧for the win!
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Isabelle Zane @isabellease.bsky.social · 22/05/2025
@pollyfordyce.bsky.social at #VariantEffect25
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Jonathan Frazer @jonnyfrazer.bsky.social · 22/05/2025
Good views, food and even better company at #VariantEffect25
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IBEC | Institute for Bioengineering of Catalonia @ibecbarcelona.eu · 21/05/2025
The first poster session just started! #VariantEffect25
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Jonathan Frazer @jonnyfrazer.bsky.social · 21/05/2025
Welcome back from the lunch break. Kicking off the afternoon session at #VariantEffect25 we welcome ​​Patrick Hsu @pdhsu.bsky.social all the way from @arcinstitute.org – Bridging biology and AI for genome design 💥🧬🤖 #SynBio #AI Let’s gooo! 🚀
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Jonathan Frazer @jonnyfrazer.bsky.social · 21/05/2025
It is a deeply inspiring story, reminding us why we do what we do.
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Jonathan Frazer @jonnyfrazer.bsky.social · 20/05/2025
Welcome back from the coffee break and to the last session of Workshop 1 of #VariantEffect25. @pascalnotin.bsky.social is giving us an overview of protein fitness prediction models! #AI #ProteinML
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Jonathan Frazer @jonnyfrazer.bsky.social · 20/05/2025
Next up at #VariantEffect25 Workshop 1 we have Noelia Ferruz! From Rosetta to Flow Matching: The Evolution of Protein Design -How Should You Begin Today?
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Jonathan Frazer @jonnyfrazer.bsky.social · 20/05/2025
Let’s get this party started! Kicking off workshop 1 of #VariantEffect25 we have Albert Escobedo — From Fitness to Free Energy: Thermodynamic Modeling of Protein DMS Data for Accurate Genetic Prediction with MoCHI 🍡🧬
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Doug Fowler @dougfowler.bsky.social · 15/05/2025
Our "Atlas of Variant Effects 2030 Roadmap" is live: zenodo.org/records/1542... 1/n
zenodo.org
Atlas of Variant Effects 2030 Roadmap: resolving human variants of uncertain significance
At the Clinical Atlas of Variant Effects meeting (CLAVE meeting, July 2024, Pittsburgh USA), we developed recommendations for a draft atlas that can be realized by 2030, with a focus on empowering gen...
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Jamison Foser @jamisonfoser.bsky.social · 14/05/2025
there are 1,100 words in this article and zero of them are "bus"
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Benedetta Bolognesi @bennibolo.bsky.social · 09/05/2025
@marianomartin.bsky.social discussing amyloid formation from random sequence extensions at our first CNS 🧠network event @ibecbarcelona.eu Find out more this week on @pnas.org! www.pnas.org/doi/10.1073/...
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Benedetta Bolognesi @bennibolo.bsky.social · 09/05/2025
Countdown officially started! #VariantEffect25 @varianteffect.bsky.social
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IBEC | Institute for Bioengineering of Catalonia @ibecbarcelona.eu · 02/05/2025
CAT 1/ 🧵 Una IA catalana desxifra el llenguatge secret de les proteïnes "enganxoses" CANYA, desenvolupada pel @crg.eu i l’ #IBEC, pot predir quan i per què es formen agregats proteics, un procés relacionat amb malalties com l’Alzheimer 👇
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Benedetta Bolognesi @bennibolo.bsky.social · 28/04/2025
Blackout pipetting @ibecbarcelona.eu
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IBEC | Institute for Bioengineering of Catalonia @ibecbarcelona.eu · 08/04/2025
🏆 Congrats to #IBEC researcher Dr. Irene Marco-Rius on winning the 2025 Anatole Abragam Prize! 🎉 Her groundbreaking work in hyperpolarized #MRI & organ-on-a-chip tech is transforming disease diagnosis & therapy monitoring. 🔬👏 #MagneticResonance #ScienceExcellence #ISMARENC2025
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Itai Yanai @itaiyanai.bsky.social · 25/03/2025
David Baker talks about how the current uncertainty and instability hinder creativity because of the difficulty in thinking long-term. From this week’s Night Science Podcast nightscience.buzzsprout.com/1744020/epis... @nightsciencepod.bsky.social
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Gabi Heller @g-heller.bsky.social · 24/03/2025
We’re looking for fellow nerds to help us make disordered proteins druggable. Love #IDPs, #MD, #NMR, #AI, #DrugDiscovery, or #MassSpec? Let’s talk. @bindresearch.org is hiring across the board: bindresearch.org/careers/ #compchem #compbio #NMRChat #TeamMassSpec #chemjobs @chemjobber.bsky.social
bindresearch.org
Careers
Careers
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John Bull @garius.bsky.social · 17/03/2025
“If she wants to know something specific, but doesn’t want people to notice her asking questions, she should simply make incorrect statements while in the company of experts. Her companions will correct her, especially if they're men.” - Advice for female agents in WW2, provided during SOE training
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Dave Baltrus 🦦 @surtlab.bsky.social · 15/03/2025
In my 25 years since high school I’ve seen 1. HIV/AIDS go from death sentence to manageable with drugs 2. Cystic fibrosis go from pretty much an extended death sentence to manageable with drugs 3. Sickle cell go from a horrible disease to (almost maybe) cured by gene therapy Simply incredible
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Nicky Whiffin @nickywhiffin.bsky.social · 02/03/2025
A few weeks ago, I had an incredibly emotional call with James Coney, a writer for the Sunday Times whose son Charlie was in the @genomicsengland.bsky.social 100k project and was recently diagnosed with ReNU syndrome. This beautiful article tells their story ❤️ www.thetimes.com/article/0bcc...
thetimes.com
My son Charlie — and the breakthrough that changed our lives
James Coney and his wife, Sarah, struggled not knowing why their 12-year-old was born with a severe learning disability. In their darkest moments, they blamed themselves. Then, out of the blue, came a...
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BWJones @bwjones.bsky.social · 27/02/2025
By @katherinejwu.com "The NIH... supported 99 percent of the drugs approved in the U.S. from 2010 to 2019. The agency has had a hand in “nearly all of our major medical breakthroughs over the past several decades,” The NIH is in a struggle for its (and our) lives. This is existential to America:
theatlantic.com
Inside the Collapse at NIH
Administration officials pressured NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now.
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IBEC | Institute for Bioengineering of Catalonia @ibecbarcelona.eu · 26/02/2025
⏰ Deadline alert! 🔴 Last week to submit abstracts & get early bird registration for the 8th Mutational Scanning Symposium! Join experts in genomics, protein science & precision medicine to discuss cutting-edge variant interpretation #VariantEffect25 🔗 events.ibecbarcelona.eu/mutational-s...
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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 25/02/2025
The 8th Annual Mutational Scanning Symposium is just around the corner! #VariantEffect25 What we are looking forward to: 🗣️Great talks! 🛠️Workshops! 🏆Poster session and awards! 🌏Amazing community! ⌛️March 1st deadline for abstracts!
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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 18/02/2025
Register soon to receive the early bird rate! Mutational Scanning Symposium "Mapping and Modelling Variant Effects at Scale" #VariantEffect25 🗓️ May 21-23, 2025 📍Barcelona (or online) ℹ️ www.varianteffect.org/mss2025
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Benedetta Bolognesi @bennibolo.bsky.social · 31/01/2025
👇👇 check this out for exciting+impactful science in a great working environment. 💻☀️
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IBEC | Institute for Bioengineering of Catalonia @ibecbarcelona.eu · 27/01/2025
🚨 PhD Opportunities at IBEC! 🚨 Join #IBEC, a Severo Ochoa Research Centre, and start your research career with one of 12 fully-funded PhD fellowships in bioengineering! 🌟
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Benedetta Bolognesi @bennibolo.bsky.social · 24/01/2025
Countdown has started! Excited to welcome you in Barcelona for the 8th Mutational Scanning Symposium #VariantEffect25 🌍 @ibecbarcelona.eu @crg.eu @varianteffect.bsky.social events.ibecbarcelona.eu/mutational-s...
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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 24/01/2025
🗓️ Mark your calendars! This is one not to miss! www.varianteffect.org/seminar-series
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Tobias Warnecke @tobiaswarnecke.bsky.social · 14/01/2025
Wanna work with us? This is one great vehicle for international postdoc applicants to join a UK lab, including ours: royalsociety.org/grants/newto...
royalsociety.org
Newton International Fellowships | Royal Society
This fellowship is for non-UK scientists who are at an early stage of their research career and wish to conduct research in the UK.
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Yaroslav Trofimov @yarotrof.bsky.social · 27/12/2024
Iranian authorities detain Italian war correspondent Cecilia Sala and jail her in Evin prison. Journalism is not a crime. Bring her home. www.ilfoglio.it/esteri/2024/...
ilfoglio.it
Journalism is not a crime. Bring Cecilia Sala home
The journalist was arrested in Iran on December 19th and is now detained in Evin Prison. Tehran has chosen to challenge everything the West universally hol
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Reuters Institute @reutersinstitute.bsky.social · 27/12/2024
Award-winning Italian reporter and podcaster Cecilia Sala was arrested in Tehran earlier this month. Our colleague @marinaadami.bsky.social profiled this pioneering and fearless journalist in this piece we published back in 2022 reutersinstitute.politics.ox.ac.uk/news/how-pio...
reutersinstitute.politics.ox.ac.uk
How a pioneering Italian podcaster is leading innovation in a print-focused media industry
“The idea for the podcast was to tell a story from the world every day,” says Cecilia Sala, the 26-year-old Italian journalist behind 'Stories'.
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Fritz Roth @fritzroth.bsky.social · 20/11/2024
Calling all systems and computational biologists in search of a faculty position: We have Assistant and Associate Professor positions! 🚀 Pittsburgh is beautiful, and we are doing amazing science here. cfopitt.taleo.net/careersectio... cfopitt.taleo.net/careersectio... Please apply by Dec 2!
cfopitt.taleo.net
Faculty.Professor.Assistant - Full-Time
Click the link provided to see the complete job description.
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Jonathan Frazer @jonnyfrazer.bsky.social · 19/11/2024
Models for predicting the effect of genetic variation have come a long way in the last few years. When it comes to diagnosis and preventative care, how can we make safe and yet efficient use of them? Here are some of our thoughts authors.elsevier.com/c/1k7J9_4GsX...
authors.elsevier.com
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