Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stage...

Whole-genome sequencing analysis of tumour and matched non-tumour host tissues of the brown bullhead catfish reveals a type of naturally occurring transmissible cancer.

Vota a las finalistas del premio Vanguardia de la Ciencia

Nature Genetics - popEVE is a proteome-wide deep generative model to identify and predict pathogenicity of missense mutations causing genetic disorders.

Evolutionary medicine is an emerging interdisciplinary field with huge potential to improve human health and tackle a broad scope of major health challenges.

EvoMG-DN is a European Doctoral Network funded by the Horizon Europe Marie Skłodowska-Curie Actions (MSCA), composed of 14 beneficiaries and associated partners from both academic and non-academic sectors.

Carboplatin adaptive therapy improves treatment efficacy without increasing daily dose due to reduced fitness of drug-resistant populations, which can be tracked using cfDNA and could direct adaptive ...

In this review, we argue that mathematical modelling is an essential tool for understanding cancer cell evolution and phenotypic plasticity. We show t…

The study by IBE:CSIC-UPF and the University of São Paulo shows the great genetic diversity of Brazil and its implications for the health of the population.

Generative models trained on natural sequences are increasingly used to predict the effects of genetic variation, enabling progress in therapeutic design, disease risk prediction, and synthetic biolog...

Two new studies could help develop better therapies for rejuvenation and regeneration

PDF | Why do genes for mental disorders persist? This article argues it is because traits with a cliff-edged fitness function are shaped to a... | Find, read and cite all the research you need on Rese...

APOBEC enzymes are part of the innate immunity and are responsible for restricting viruses and retro

Evolutionary Biology and Ecology of Cancer