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Becki Lee

@beckilee.bsky.social
3K followers 1.5K following 78 posts

Melanoma oncologist at The Christie. Wellcome early career fellow at University of Manchester, The Francis Crick and UCL. Interested in tumour local and systemic immune changes, metastasis, ctdna and cancer evolution. Music, art, politics, hiking.

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Becki Lee @beckilee.bsky.social · 22/05/2026
Pleased to share results from the CAcTUS Phase II trial of ctDNA-guided therapy in BRAF-mutant advanced melanoma are now published! 🌵🧬 CAcTUS is the first melanoma trial to adapt treatment based on ctDNA testing. Read: www.nature.com/articles/s41...
nature.com
Use of circulating tumour DNA to prospectively guide a switch from targeted to immune therapy in BRAF mutant advanced melanoma: the randomised phase II CAcTUS trial - Nature Communications
Targeted therapy (with BRAK and MEK inhibitors) and immune checkpoint blockade have improved survival for patients with advanced BRAF-mutant cutaneous melanoma, however, the optimal scheduling for the...
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Ben Goldacre @bengoldacre.bsky.social · 23/02/2026
OpenSAFELY is open from today! Huge thanks to all who supported this vast collaboration: whole population GP data; in a productive platform; innovative privacy protections; unprecedented support from professions, privacy campaigners; &c Now it's over to users! www.bennett.ox.ac.uk/blog/2026/02...
bennett.ox.ac.uk
OpenSAFELY news: you can apply to do non-COVID research, from today! | Bennett Institute for Applied Data Science
We are delighted to announce that - from today - you can submit applications to the OpenSAFELY service for non-COVID-19 studies.
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Mark O’Neill 🐻 @radiobeartime.com · 22/02/2026
www.deadlanguagesociety.com/p/how-far-ba... I cannot speak as to the accuracy of the piece yet I found it a fascinating exercise @adamroberts.bsky.social @drlauravarnam.bsky.social
deadlanguagesociety.com
How far back in time can you understand English?
An experiment in language change
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Jon Lim, FRCP PhD @drjonlim.bsky.social · 03/02/2026
👉...cutting-edge science, clinical insights & discussions re: real-world implementation of TIL therapy. Featuring keynote speakers: Inge Marie Svane 🇩🇰 & Sebastian Klobuch 🇳🇱. @sklobuch.bsky.social @debrajosephs.bsky.social @turajliclab.bsky.social @beckilee.bsky.social
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Becki Lee @beckilee.bsky.social · 22/01/2026
Exciting conference alert! sites.manchester.ac.uk/from-lab-to-... Fantastic speakers including Chris Marine, Christian Blank Melanoma evolution Local microenvironment of melanoma Melanoma-host interactions Precision immunotherapy Emerging therapeutics Clinical trials and real-world data
lab to life
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Jon Lim, FRCP PhD @drjonlim.bsky.social · 01/12/2025
🩺 Fantastic opportunity for #YoungOncologists: ICF-ESMO programme for an 8-week observership. We've excellent opportunities here in Manchester & would be happy to support (✉️: the-christie.observers@nhs.net). @christieinstitute.bsky.social @myesmo.bsky.social 📥 For more info (due 25 Jan 2026) 👇
esmo.org
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Becki Lee @beckilee.bsky.social · 30/11/2025
Excited about not one but 2 fantastic conferences in Manchester! So timely as cell therapies are on the standard care horizon!
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Jon Lim, FRCP PhD @drjonlim.bsky.social · 30/11/2025
⏰ Calling all melanoma enthusiasts! The abstract submission deadline for the inaugural “Lab to Life: Innovations in Melanoma Research Conference UK 2026” has been extended to 19 December 2025! Happening 12-13 March 2026 at The Midland Hotel, Manchester. Submit your abstract and register here:
sites.manchester.ac.uk
Home
Lab to Life: Innovations in Melanoma is a UK conference in Manchester on cutting-edge melanoma research, translational science and advances in treatments.
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Becki Lee @beckilee.bsky.social · 22/11/2025
Cancer detectives a hit in our house! Bench to bedside look at the DETECTION trial- Inspiring scientists of the future and an insight into why science is important, the breakthroughs they fund and what it means to the people involved www.channel4.com/programmes/c...
Cat watching cancer detectives
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Becki Lee @beckilee.bsky.social · 31/10/2025
Happy Halloween from these two!
CatCat
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Becki Lee @beckilee.bsky.social · 16/10/2025
Melanoma UK today visited the Smiths Melanoma hub today learning about the amazing work all of these lovely people are doing! Thanks for funding us! @mcrcnews.bsky.social
Lab group
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Séamus O’Reilly MDPhD @seamusoreilly.bsky.social · 14/10/2025
Attending #ESMO25 Join us to learn about sustainability integration into cancer care and the environmental impacts of AI 👇 @myesmo.bsky.social @robchuter.bsky.social @beckilee.bsky.social @pawelsobczuk.bsky.social @ouchinternational.bsky.social @irishdocsenv.bsky.social @cancertrialsie.bsky.social
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Becki Lee @beckilee.bsky.social · 07/10/2025
Amazing work throughout the UK to smash our recruitment target!
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Carers In STEMM @carersinstemm.bsky.social · 26/09/2025
We are pleased to announce the publication of our STEMM sector-wide survey The report highlights our findings & suggests recommendations. Now available to download here carersinstemm.co.uk Please share especially w/ institutions, funders & allies @laurawolz.bsky.social @carterlj.bsky.social
Screenshot of the front page of the carers in STEMM survey report
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Max Kozlov @maxkozlov.bsky.social · 25/09/2025
NEW: Nature trained AI to predict which NIH grants from 2014 would have been cut if the Trump admin had its way back then — and what science would have been lost to history. "The results show the damage that cuts in funding can do to research, and the unpredictable nature of the research process."
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Adrian Liston @labliston.bsky.social · 19/09/2025
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
currentprotocols.onlinelibrary.wiley.com
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Becki Lee @beckilee.bsky.social · 11/09/2025
Very pleased to say DETECTION2 has just randomised it's 50th patient! Awesome work by patient groups @melanomafocus.bsky.social , UK clinical teams @christieinstitute.bsky.social R+I and SCTU funded by @cancerresearchuk.org
media.tenor.com
snoopy is standing in front of a fireworks display and says `` congratulations ! ''
Alt: snoopy is standing in front of a fireworks display and says `` congratulations ! ''
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Bluesky @bsky.app · 08/09/2025
v1.108 is rolling out today 🚚 Now live, at long last: Bookmarks, aka Saved Posts. For all those posts you'll definitely plan to come back to! Update the app and give it a try. The button is right down there 👇
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Becki Lee @beckilee.bsky.social · 22/08/2025
The Lee lab is expanding! We are really interested in mechanisms of local and systemic immune tolerance particularly in liver metastases - X2 research technicians 💡 Creative fun environment 🌱 Opportunities to grow 🫂 Highly collaborative with clinical+basic research 📢 Please spread word!
jobs.manchester.ac.uk
Research Technician:Oxford Road
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Metastasis Research Society @metastasisresearch.bsky.social · 06/08/2025
Calling all ECRs in cancer and metastasis research. Don't forget to register for the upcoming ECR Virtual Symposium in November (FREE for MRS members). More details here metastasis-research.org/2025/08/06/2...
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Becki Lee @beckilee.bsky.social · 30/07/2025
⭐We have a clinical fellow opportunity with the melanoma team! ⭐ Very friendly and supportive team Lots of learning opportunities including clinical trials and immune therapy Apply here👇 urldefense.com/v3/__https:/...
urldefense.com
Job vacancy: Clinical Research Fellow, The Christie NHS Foundation Trust, Manchester | trac.jobs
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Becki Lee @beckilee.bsky.social · 24/07/2025
🚨 Exciting new paper alert 🚨 From the Marie lab ⭐They have identified new melanoblast cell states which are reawakened in metastasizing and immunotherapy resistant melanoma ⭐ Can target using hdac inhibitors #melsm #melanoma #cancer www.biorxiv.org/content/10.1...
biorxiv.org
Transitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasis
Melanoma plasticity, driven by phenotype state switching, underlies clinically relevant traits such as metastasis and therapy resistance. As melanoma progression is thought to recapitulate aspects of ...
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Jose M. Adrover @adrover.bsky.social · 17/07/2025
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) www.nature.com/articles/s41...
nature.com
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
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Becki Lee @beckilee.bsky.social · 02/07/2025
Mathematical models and ctdna have reached the clinic - the ultimate personalised trial testing adaptive targeted therapy highlighted in the news today! #EBEcancer25 www.express.co.uk/life-style/h...
express.co.uk
UK cancer breakthrough as simple blood test could help pinpoint treatment
EXCLUSIVE: Skin cancers can be among the most aggressive forms of the disease so using drugs to shrink them must be used with precision.
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Becki Lee @beckilee.bsky.social · 02/07/2025
Absolutely loving this course - fantastic discussions between all and the delegates and faculty. So many exciting Q's coming out of this!
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eriksahailab.bsky.social @eriksahailab.bsky.social · 17/06/2025
Excited to share our new study on how resistance to AKT inhibition is linked to lineage differences within breast cancer 👇🏽 Stellar work @colindhratcliffe.bsky.social www.biorxiv.org/content/10.1... and also surprisingly/worryingly good AI generated podcast 🎧 notebooklm.google.com/notebook/28e...
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The Francis Crick Institute @crick.ac.uk · 03/06/2025
The deadline for early bird registration for the 5th Crick Cancer Conference has been extended. See the full programme and book by 15 July to take advantage of reduced ticket rates for early bookers ⤵️ www.crick.ac.uk/whats-on/5th...
crick.ac.uk
5th Crick International Cancer Conference
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Becki Lee @beckilee.bsky.social · 03/06/2025
Super proud of our fellow Tomasso Bosetti presenting his poster at #ASCO25 on the impact of timing of immune therapy and outcomes across cancers - the early 🐦catches the 🪱!
Conference poster
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Becki Lee @beckilee.bsky.social · 03/06/2025
Our data and the lung cancer trial also presented are very compelling for early time of day immune therapy treatment urldefense.com/v3/__https:/...
urldefense.com
Program Guide – ASCO Meeting Program Guide
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Trevor Graham @trevorgraham.bsky.social · 22/05/2025
Single cell whizz with green fingers for molecular genomics? Want to develop and apply new technologies for profiling #cancer #evolution? Like single cell WGS + ATAC: www.biorxiv.org/content/10.1... Perhaps our senior scientific officer role is for you? jobs.icr.ac.uk/vacancies/12... @icr.ac.uk
jobs.icr.ac.uk
Higher or Senior Scientific Officer in Sutton | The Institute of Cancer Research
View details and apply for this Higher or Senior Scientific Officer vacancy in Sutton. Salary : Salary from 39,805 to 49,023 Reporting to: Prof Trevor Graham Duration of ...
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Becki Lee @beckilee.bsky.social · 20/05/2025
Happy international trials day! Bit more info on one of the trials we have developed from research done @cruk-mi.bsky.social and now bringing to patients thanks to CRUK and @southamptonctu.bsky.social
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Rob Noble @robjohnnoble.bsky.social · 06/05/2025
The Department of Integrated Mathematical Oncology @mathonco.bsky.social (Moffitt Cancer Center, Tampa, Florida) is also advertising an Open Rank Tenure-earning Faculty Position in Mathematical Oncology. For this and other openings see mathematical-oncology.org/jobs
mathematical-oncology.org
Jobs
mathematical-oncology.org
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Waggoner Lab @labwaggoner.bsky.social · 05/05/2025
Review @cp-immunity.bsky.social Role of specialized sensory neuron subtypes in modulating peripheral immune responses www.cell.com/immunity/ful...
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Becki Lee @beckilee.bsky.social · 05/05/2025
Fantastic news for Europe - does anyone know what this means for the UK and whether we are part of it now we are back in Horizon?
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Cancer Research UK Manchester Institute @cruk-mi.bsky.social · 02/05/2025
We are recruiting - two exciting positions to check out this Bank Holiday weekend: 🥼 #Postdoctoral Scientist with @sylvaindelaunay.bsky.social 🥼 Amit Patel #Leukaemia Research Fellowship & Cancer Research UK Manchester Institute Senior Clinical Institute Fellow www.cruk.manchester.ac.uk/careers/
Photograph shows a closeup of a series of microscope lens against a bright green background

Logo shows the Cancer Research UK Manchester Institute Logo

Text says "We are recruiting" and "see all opportunities at cruk.manchester.ac.uk/careers/"
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Cold Spring Harbor Laboratory @cshlnews.bsky.social · 29/04/2025
A new Science summary spotlights a paper by CSHL’s Tobias Janowitz and colleagues that uncovers a neural circuit linking inflammation to reduced motivation in a mouse model of cancer cachexia. Check out the Science summary here: www.science.org/doi/10.1126/... #Cachexia #ScienceMagazine
science.org
How does cancer affect motivation?
Inflammatory cytokines hijack a brain circuit to cause apathy in cancer
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Waggoner Lab @labwaggoner.bsky.social · 26/04/2025
Review @annualreviews.bsky.social @lindavsinclair.bsky.social @cantrell-lab.bsky.social Protein Synthesis and Metabolism in T Cells www.annualreviews.org/content/jour...
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Becki Lee @beckilee.bsky.social · 24/04/2025
20th patient recruited to DETECTION2! 🎉 Amazing work across the UK to get this study done!
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Becki Lee @beckilee.bsky.social · 23/04/2025
Great paper from the Fairfax lab interrogating the effect of CMV status and immune therapy response www.nature.com/articles/s41...
nature.com
CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade - Nature Medicine
Analysis of multiple cohorts of patients with melanoma demonstrates a positive association between cytomegalovirus serostatus and overall survival in patients treated with monotherapy but not combinat...
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Waggoner Lab @labwaggoner.bsky.social · 22/04/2025
IL-10 targets IRF transcription factors to suppress IFN and inflammatory response genes by epigenetic mechanisms @natimmunol.bsky.social www.nature.com/articles/s41...
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Waggoner Lab @labwaggoner.bsky.social · 14/04/2025
Review @natbiotech.nature.com Engineering innate immune cells for cancer immunotherapy www.nature.com/articles/s41...
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Abhishek Garg LAB @abhishekgarglab.bsky.social · 11/04/2025
📢Happy to share our @natrevimmunol.bsky.social article; Result of #collaboration with @deadoc80.bsky.social @labliston.bsky.social & K Smith! 📑Read here: rdcu.be/ehm67 🔥Take🏠msg: Time to move away from narrow concept of #exhausted T cells to other #hypofunctional #states! 1/6🧵 @oncodaily.bsky.social
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Becki Lee @beckilee.bsky.social · 03/04/2025
Melanoma team are out in force at EADO/WCM with some really interesting data on adjuvant therapy in old Vs young patients with melanoma
Poster presentation 
Poster presentation
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Becki Lee @beckilee.bsky.social · 03/04/2025
New video highlighting our work translating bench work to the clinic. It's exciting to see how liquid biopsies can be used to track cancer in real time enabling switching of treatments for patients- watch this space for the publication!
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Becki Lee @beckilee.bsky.social · 31/03/2025
This is going to be so much fun! Get those applications in!
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Becki Lee @beckilee.bsky.social · 28/03/2025
Sometimes you just got to take a day off and enjoy the view
Sky and tree
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Becki Lee @beckilee.bsky.social · 07/03/2025
Even my cat knows how important reading about science is! Thinking of all those standing up for science today and every day! #standupforscience2025 #sciencenotsilence #scienceforall
Cat looking at computer screen
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Cancer Research UK Manchester Institute @cruk-mi.bsky.social · 06/03/2025
We are recruiting #postdoctoral scientists to join @giampazolias.bsky.social and our Cancer Immunosurveillance group 🧪🥼🧫🦠 For full details of the position, please visit our website: www.cruk.manchester.ac.uk/career/mi-24... Closing date: 4th April #OncoSky #CanSky #CancerResearch #microbiome
Job Advert for Postdoctoral Scientist in the Cancer Immunosurveillance Group

Salary £37,000-£44,852 dependent upon qualifications and experience

Job ID MI/24/55-2

Apply by 4th April 2025
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Denis Wirtz @deniswirtz.bsky.social · 06/03/2025
These are extremely challenging times for early-career faculty. Here is my office's small contribution to make their hard and important work a bit easier: Download our curated and comprehensive database of funding opportunities for early-career faculty. Here: research.jhu.edu/rdt/funding-...
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EACR - European Association for Cancer Research @helloeacr.bsky.social · 05/03/2025
Join us today by signing the Milan Declaration! The EACR, alongside 55 Nobel Laureates and 70+ organisations, has signed the Milan Declaration on the Crucial Role of Science in meeting Global Challenges: www.febs.org/milan-declar...
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