Reposted by Calum Gabbutt
In a new preprint led by Ves Manojlovic, we develop an agent-based model and an ABC-SMC inference workflow to infer tumour growth parameters from methylation arrays, focussing on sites whose states fluctuate on clinically relevant timescales. We applied this workflow to 10 colorectal tumours. 1/2
biorxiv.org
Fluctuating DNA methylation sites encode colorectal tumour growth history
Determining the nature of human tumour growth is challenging given the impracticality of obtaining detailed data across time. A promising solution is to examine DNA regions whose methylation states fl...
