Duan et al. solved the structure of ATRX ATPase-nucleosome complex, uncovering three distinctive features that enable ATRX to remodel nucleosomes. These newly identified features are indispensable for protecting cells from G4 stress. The work provides a framework for interpreting both known and future mutations linked to ATRX-related disorders.

Mitochondria are dynamic organelles that remodel their shape to regulate cell fate. Mitochondrial division involves interactions with the endoplasmic reticulum (ER), lysosomes, and trans-Golgi network...

Epithelial tissues undergo dynamic transitions between fluid-like collective motion and mechanically jammed states during development, injury repai...

Protocols for asymmetric synthesis and analysis of chiral materials

A recent study reveals how a single stop codon helps alphaviruses evade immune defenses in both mosquitoes and humans

QC6352, originally developed as a KDM4 inhibitor, exerts its anticancer activity in glioblastoma models primarily through inhibition of dihydroorotate dehydrogenase, a key enzyme in de novo pyrimidine...

An approach has been developed for NMR observation of proteins within intact mitochondria through delivery of proteins directly into isolated mitochondria via electroporation. This method offers a fra...

YouTube video by Broad Institute

YouTube video by Broad Institute

Nitroarenes are unstable in microbial cultures, limiting the biomanufacturing of these industrially and pharmaceutically important chemicals. Genome engineering of nitroreductase-deficient E. coli str...

Contribute to openai/math development by creating an account on GitHub.

How a group of historians took years to imagine Zotero, the research application that would eventually be used by millions

Postdoctoral Research Associate in Mathematical and Statistical Methods for Genome Privacy (Fixed Term) in the Department of Applied Mathematics and Theoretical Physics at the University of Cambridge.

Current genetic screens face a trade-off between scaling to large mutant libraries and measuring information-rich phenotypes. SPARCS automates laser microdissection to enable pooled forward genetic sc...

UniProt is allocated nearly half of new Horizon Europe funding announced today to safeguard three critical biodata resources for the life sciences and biotechnology. The grant involves its two Europea...

Metabolic engineering of mammalian cells is simplified and scaled by screening ‘shotgun’ modifications.

The 2026 Nobel Prize in Physics has been awarded to Francis Halzen “for decisive contributions to the IceCube Neutrino Observatory and the discovery of ...

Density-dependent regulation of collective order through collision sensing and collision-induced reversals provides a navigational advantage to Pseudomonas aeruginosa during surface colonization and n...

In a recent Nature paper, Witus et al. show that endogenous purine nucleotides and thiopurine drugs act as molecular glues to block purine synthesis by tethering PPAT to its inhibitor NUDT5 via a pocket highlighted by plasticity and cooperative interactions.