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Nonia Pariente

@npariente.bsky.social
4K followers 2.2K following 645 posts

Editor in Chief of the #NonProfit, #OpenAccess journal @plosbiology.org Former Chief Editor of Nature Microbiology. #Virologist. #Feminist. #Spaniard in the UK. #Galician. #European always. Views my own. orcid.org/0000-0002-3666-5683

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Nonia Pariente @npariente.bsky.social · 10h
This is really cool 🧪
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Kate Baker @ksbakes.bsky.social · 25/09/2026
We have an open Assistant/Associate Professor position in Pathogen Biology at the Department of Genetics - come and join us! 🦠 🧫 🧬https://www.cam.ac.uk/jobs/assistantassociate-professor-in-pathogen-genetics-pc51175
cam.ac.uk
Assistant/Associate Professor in Pathogen Genetics
Applications are invited for an Assistant or Associate Professorship in Pathogen Genetics to be held in the Department of Genetics. We are searching for a talented individual with a track record of fu...
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Yasin Dagdas @plantophagy.bsky.social · 29/09/2026
@e3chembio.bsky.social is telling us their efforts in understanding the role of giant E3 ligases in disease set up. #EMBOUbiquitin
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Nonia Pariente @npariente.bsky.social · 28/09/2026
⬇️⬇️ Important tool to identify and track #Dengue virus lineages #ViroSky 🧪
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PLOS Biology @plosbiology.org · 28/09/2026
#TrendingNow | How can we improve research #reproducibility? @kdcobey &co surveyed more than 1,900 biomedical researchers for thoughts on irreproducibility in research results, conducting replication studies, and relevant funding and training #ICYMI #AcademicSky 🧪 plos.io/3ApZJ4N
plos.io
Biomedical researchers’ perspectives on the reproducibility of research
There is growing interest in the reproducibility of research and ways to enhance transparency. This study uses an international survey of more than 1900 biomedical researchers to reveal the perceived…
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PLOS Biology @plosbiology.org · 21/09/2026
How do the brain's anatomical architecture & functional activity patterns become established during early life? This study of developmental changes in the #brain from perinatal to toddlerhood reveals the organization of networks & #cognitive development @plosbiology.org 🧪 buff.ly/UESbFve
Top: This illustration depicts the evolving spatial pattern of brain structure–function coupling from the perinatal period through infancy. Cortical colors represent regional coupling strength, while the circular arrangement and arrows indicate the temporal progression of early brain development. Bottom: This image separately visualizes the brain’s structural and functional organization. The left panel shows colored white-matter fiber pathways, whereas the right panel displays cortical functional connections as colored nodes and edges embedded within a brain surface. Image created by Ruoke Zhao, Dan Wu.
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PLOS Biology @plosbiology.org · 21/09/2026
#TrendingNow | How and why does #stuttering develop in children? This Unsolved Mystery looks at how genetics, interacting neural hierarchies, social context, and reward circuitry contribute to the many facets of stuttering. #ICYMI #NeuroSky 🧪 buff.ly/kVPTXuA
buff.ly
Knowns and unknowns about the neurobiology of stuttering
The origin of stuttering is closely linked to early brain development in children but ultimately unknown. This Unsolved Mystery highlights critical questions that could inspire future research to…
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PLOS Biology @plosbiology.org · 22/09/2026
#TrendingNow | The anatomy of multicellular structures such as #biofilms influences how cells can access resources. This study shows that #bacteria in biofilms divide along oxygen gradients, affecting the physiology and drug susceptibility of biofilm subzones. #ICYMI #MicroSky 🧪 buff.ly/aHITgjp
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Cellular arrangement impacts metabolic activity and antibiotic tolerance in Pseudomonas aeruginosa biofilms
Cells must access resources to survive, and the anatomy of multicellular structures influences this access. This study shows that bacteria in biofilms divide along oxygen gradients; their end-to-end…
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Nonia Pariente @npariente.bsky.social · 21/09/2026
😎 paper alert Can viral infections reactivate dormant cancer cells? How does inflammation triggered by pathogens (or other stresses) intersect with anticancer immunity? Rincon, de Gregori and cols discuss the processes at this important interface 🧪 ⬇️
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Nonia Pariente @npariente.bsky.social · 21/09/2026
😎 paper alert Can viral infections reactivate dormant cancer cells? How does inflammation triggered by pathogens (or other stresses) intersect with anticancer immunity? Rincon, de Gregori and cols discuss the processes at this important interface 🧪 ⬇️
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PLOS Biology @plosbiology.org · 17/09/2026
#Flaviviruses reshape cell membranes to build replication sites, but how are these organized? This study shows that homotypic #membrane tethering driven by host ER protein atlastin-2 is essential for organizing these sites & supporting #viral replication @plosbiology.org 🧪 buff.ly/9MBKCbR
Left: A549 cells expressing HA-tagged ATL2 were infected with ZIKV. After 48 h, cells were fixed with paraformaldehyde and glutaraldehyde, followed by staining for dsRNA and HA using specific antibodies and reversible saponin permeabilization. Cells were imaged by confocal microscopy, then immediately embedded and processed for EM imaging. Right: Model. ATL2 membrane tethering is critical for the spatial organization of flavivirus genome replication. ATL2 tethering dimers bring ER membranes into close contact, facilitating the trafficking of newly synthesized viral genomes from existing vROs into vROs forming on juxtaposed membranes (top). This close connection forms a microdomain which brings together the necessary factors for nascent vRO formation and shields the cytosol-exposed viral RNA from innate immune sensors. Because membrane tethering is reversible, this also permits the expansion of viral genome replication away from sites of existing vRO biogenesis. In the absence of ATL2 membrane tethering (bottom), viral genomes extruded from the vRO are exposed to the cytosol and more likely to form new vROs on the same membrane, leading to the concentration of sites of vRO biogenesis and increased recognition by RIG-I-like receptors (RLRs) in the cytosol.
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PLOS Biology @plosbiology.org · 17/09/2026
#TrendingNow | Lighting conditions for laboratory mammals are currently set according to the sensitivity of human vision. This Consensus View defines alternative ‘animal-centric’ metrics and provides guidance for their application. #ICYMI #biomedical #AcademicSky 🧪 buff.ly/hk3IoQK
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Recommendations for measuring and standardizing light for laboratory mammals to improve welfare and reproducibility in animal research
Lighting conditions for laboratory mammals is currently set according to the sensitivity of human vision. This Consensus View defines alternative ‘animal-centric’ metrics and provides guidance for…
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PLOS Biology @plosbiology.org · 18/09/2026
Most #bacterial #immune systems raise an alarm when they sense a #phage. This Primer explores a @plosbiology.org study showing how type II Panoptes reverses this logic by maintaining a quiet signal & sensing infection through its sudden disappearance 🧪 Paper: buff.ly/1ixwg9v Primer: buff.ly/WmnHZBp
Type II Panoptes inverts the logic of nucleotide signaling in bacterial immunity. Top: In type III CRISPR-Cas, Cas10 synthesizes cyclic oligoadenylates (cAn) only upon infection; the signal binds and activates a CARF effector, arresting growth. Type II Panoptes does the reverse. Its mCpol enzyme produces cA3 constitutively at low levels, and this signal keeps the CARF-TM effector repressed. Infection is sensed not as the appearance of a signal, but as its disappearance: when phage enzymes (Acb1 given as an example) deplete cA3, the effector is released and growth arrests. Bottom: Because Acb1 evolved to disable cyclic-nucleotide defenses such as type III CRISPR, a phage carrying it strips cA3 as collateral damage and triggers Panoptes. A phage lacking Acb1 avoids this trap but remains vulnerable to CRISPR. Together, the two systems could impose an evolutionary trade-off on the phage.
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PLOS Biology @plosbiology.org · 18/09/2026
#TrendingNow | This study reveals how the >10,000 different possible amino-acid mutations in hemagglutinin affect cell entry, receptor preference, protein stability and neutralization by antibodies for H5 #influenza, which is a potential pandemic threat. #ICYMI #MicroSky🧪 buff.ly/ojZfSyG
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Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance
H5 influenza is considered a potential pandemic threat. Using deep mutational scanning, this work reveals how the >10,000 different possible amino-acid mutations in hemagglutinin affect cell entry,…
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Aaron Reichlin-Melnick @reichlinmelnick.bsky.social · 18/09/2026
My grandfather, who is 102 and a medical doctor, has told me about the times before polio was cured. Most years, upon returning to school after summer’s break, there would be some children would didn’t make it back to school because of polio.
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PLOS Biology @plosbiology.org · 16/09/2026
#Phages can evade #bacterial #immunity by disrupting #antiviral signals like cA3, triggering the Panoptes defense systems. @mfwhite2.bsky.social &co show that Type II Panoptes detects cA3 loss and activates a CARF-TM effector to disrupt membranes & stop infection @plosbiology.org 🧪 buff.ly/1ixwg9v
Left: Organisation and mechanism of the Panoptes System. In type I Panoptes systems, mCpol is constitutively active, generating signalling molecules that inactivate the cognate effector, 2TMβ. When an infecting phage expresses a sponge protein, the cyclic oligonucleotide pool is depleted. The Panoptes effector oligomerises, leading to membrane disruption and growth arrest or cell death. Right: CARF-TM model structure and cA3 binding. Alphafold3 model of CARF-TM in complex with cA3, including POPG molecules to simulate the membrane bilayer. The position mutated to generate the truncated CARF protein is shown by black arrows.
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PLOS Biology @plosbiology.org · 16/09/2026
#TrendingNow | Is cancer is purely a ‘genetic disease’? This Essay delves into cancer omics data that questions the somatic mutation theory and presents theories based on gene regulatory networks and tissue fields that help explain inconsistencies in the data. #ICYMI #cancer 🧪 buff.ly/s49Y8ms
buff.ly
The end of the genetic paradigm of cancer
Genome sequencing results and single-cell transcriptomics continue to produce findings that challenge the idea that cancer is purely a ‘genetic disease’. This Essay delves into cancer omics data that…
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PLOS Biology @plosbiology.org · 16/09/2026
🧪 #Microsky #Virosky
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Malcolm White @mfwhite2.bsky.social · 16/09/2026
Our paper on type II Panoptes is now published at PLOS Biology with new data on phage escapers - quite a step up in microbiology for our lab, led by Sabine Gruschow. Thanks to @erc.europa.eu for funding dx.plos.org/10.1371/jour...
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PLOS Biology @plosbiology.org · 15/09/2026
#TrendingNow | Current treatments for #AlzheimersDisease are hampered by limited efficacy, side effects and high costs. This Essay highlights non-invasive sensory stimulation as a promising emerging technology for the treatment of Alzheimer's disease. #ICYMI #NeuroSky 🧪 buff.ly/jYJJu6u
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Innovations in noninvasive sensory stimulation treatments to combat Alzheimer’s disease
Current treatments for Alzheimer disease are hampered by limited efficacy, side effects and high costs. This Essay highlights non-invasive sensory stimulation as a promising emerging technology for…
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PLOS Biology @plosbiology.org · 14/09/2026
#TrendingNow | There has been an explosion of formulaic research articles, including inappropriate study designs and false discoveries. This study highlights how new unethical research practices using #AI are exploiting the US NHANES resource. #ICYMI #biomedical 🧪 buff.ly/PxKxi6m
buff.ly
Explosion of formulaic research articles, including inappropriate study designs and false discoveries, based on the NHANES US national health database
The combination of AI and national health databases offers opportunities, but may also be exploited by unethical agents. This study shows that there has been an explosion of formulaic research…
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PlantEvolution 🌱🌾 @plantevolution.bsky.social · 14/09/2026
Please consider submitting comments on the implementation for genome edited plants in the EU. Reminder: this is not the place for general statements regarding your personal vie of #NGT. Instead, the Commission is asking for input for the development of workable rules.
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Inga Songailiene @ingasongailiene.bsky.social · 11/09/2026
great stuff! Tried it already 🥼
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Diversify Microbiology @diversifymicro.bsky.social · 11/09/2026
UNC Greensboro Department of Biology is hiring for three positions this year including one in microbiology! spartantalent.uncg.edu/postings/35918
spartantalent.uncg.edu
Assistant Professor Microbiology
The Department of Biology at UNC Greensboro (UNCG) seeks an individual with a strong record of accomplishment in microbiology broadly defined for a tenure-track faculty position at the rank of Assista...
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PLOS @plos.org · 08/09/2026
The first articles have now been published in our new journal, PLOS Ecosystems. These papers bring together open research from multiple disciplines to address the challenges facing our terrestrial, freshwater and marine ecosystems. Read the first articles: buff.ly/8rsP0Z3
PLOS Ecosystems banner announcing "First articles now published" and urging readers to "Read the first papers," set over a split underwater coral and shoreline photo to promote multidisciplinary ecosystem research.
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Prof Ian Hall @ianhall.bsky.social · 09/09/2026
🌊 Kelp forests are estimated to be losing ~1.8% (~11,500 km²) of their area annually. The striking part? The carbon-sink capacity lost from the climate-driven decline is 1,000–10,000× larger than the gains achieved via seaweed restoration, afforestation & farming. journals.plos.org/plosbiology/...
journals.plos.org
Seaweed carbon removal cannot keep up with climate-driven loss
Seaweed forests are widely viewed as natural climate solutions, yet warming oceans are driving their rapid decline. This Essay reveals that losses are outpacing restoration efforts by orders of magnit...
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Cameron Thrash @jcamthrash.bsky.social · 02/09/2026
The 100 Diatom Genomes Project journals.plos.org/plosbiology/... #jcampubs
journals.plos.org
The 100 Diatom Genomes Project
This Community Page presents the 100 Diatom Genomes Project, which aims to sequence the genomes and transcriptomes of 100 diatom species across major lineages, life forms and ecological strategies. Th...
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PLOS Biology @plosbiology.org · 10/09/2026
#Seaweed forests are widely viewed as natural climate solutions, but warming oceans are driving their rapid decline. Karen Filbee-Dexter, @twernberg.bsky.social &co reveal that losses are outpacing restoration efforts by orders of magnitude, raising urgent concerns @plosbiology.org 🧪 buff.ly/C8mfltu
Left: Productive Laminaria hyperborea kelp forests in Norway (credit: Jonas Thomar). Right:  Interventions to reduce degradation of seaweed forests, listed in rough order of area affected by stressor. These actions (1) should be the first steps in seaweed forest conservation and can lead to prevention of future loss in intact areas or passive restoration in degraded areas (2). In cases where the outcome following step 1 is no recovery, additional active restoration interventions such as seeding, grazer control, or transplanting may be necessary (3).
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PLOS Biology @plosbiology.org · 10/09/2026
#TrendingNow | The proportion of studies that successfully translate from animals to humans may be greater than we think. However, the low rate of final regulatory approval indicates potential design flaws of both animal studies and early clinical trials. #ICYMI #biomedical 🧪 buff.ly/XAysMWI
journals.plos.org
Analysis of animal-to-human translation shows that only 5% of animal-tested therapeutic interventions obtain regulatory approval for human applications
Based on the analysis of 376 therapies in 54 human diseases, this study shows that, contrary to widespread assertions, the proportion of successful animal-to-human translation may be higher than…
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Nonia Pariente @npariente.bsky.social · 12/09/2026
Experimenting with new models of peer review is essential to move to a future of #publishing that better serves science and researchers ⬇️ DiscoveryStack is an interesting attempt, aiming to separate the assessment of quality & impact @maxkrummel.bsky.social @richardsever.bsky.social 🧪
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Nonia Pariente @npariente.bsky.social · 12/09/2026
We’re reposting some trending articles from our recent past, for those that may have missed them. Below is an excellent resource from @aharms485.bsky.social lab expanding the BASEL phage collection 🧪#ViroSky #Microsky
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Francesca Cesari @francesari.bsky.social · 09/09/2026
Tested in female mice only, semaglutide given late in life improved physical, metabolic and cognitive function and extended lifespan. The mechanisms partly overlap with calorie restriction, but human ageing effects are untested. 🧪 www.nature.com/articles/s41...
nature.com
Late-life semaglutide treatment slows ageing and extends lifespan in female mice - Nature
Semaglutide treatment for 3 months in female mice improved physiological function, attenuated hallmarks of ageing and modulated nutrient sensors and conserved genetic regulators of ageing.
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Antonio Martínez Ron @aberron.bsky.social · 06/09/2026
La candidez y permisividad con la que las democracias liberales han tratado el fascismo las vamos a pagar muy caras.
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Nonia Pariente @npariente.bsky.social · 04/09/2026
Whatever could go wrong in this scenario, I wonder
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Thomas Mock @thomasmock.bsky.social · 04/09/2026
Thanks Nonia! Indeed, we aim to go beyond 100 diatom genomes based on a global community effort. Another goal is to link genetic variants with traits for integrative diatom research. This helps to address questions from the origin of evolutionary innovations to ecology and biotechnology.
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Nonia Pariente @npariente.bsky.social · 04/09/2026
After the wildly successful 1000 fungal genomes project... make way for the 100 #diatom genomes project (to go beyond 100 eventually) The 100DGP portal provides users with access to all genome assemblies, transcriptomes and annotations (phycocosm.jgi.doe.gov/100_Diatom_G...) @plosbiology.org 🧪
phycocosm.jgi.doe.gov
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Thomas Mock @thomasmock.bsky.social · 01/09/2026
On behalf of 108 colleagues and friends from 11 countries, thrilled to share the first paper from our 100 #Diatom Genomes Project (100DGP). Just out @plosbiology.org | @norwichmicro.bsky.social | @ueaenv.bsky.social | @jgi.doe.gov doi.org/10.1371/jour...
doi.org
The 100 Diatom Genomes Project
This Community Page presents the 100 Diatom Genomes Project, which aims to sequence the genomes and transcriptomes of 100 diatom species across major lineages, life forms and ecological strategies. Th...
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Nonia Pariente @npariente.bsky.social · 01/09/2026
Timely issue given situations such as the one below - women's basic physiology is far from understood, chronically underfunded and understudied. This needs to change to improve health outcomes. @plosbiology.org calls for more funding & more exposure of basic research in this field plos.io/4ckiAOu
plos.io
Basic research into Women’s Health should be a priority for all
Despite recent progress in clinical research into Women’s Health, basic research is still lagging behind. This Editorial calls for a renewed focus on basic physiology research into both sexes to close the gap.
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Nonia Pariente @npariente.bsky.social · 01/09/2026
This is an issue particularly close to my heart - women's basic physiology is far from understood, chronically underfunded and understudied. This needs to change to improve health outcomes. Here @plosbiology.org calls for more funding for basic research in this area & more exposure of the results 🧪
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U. Nomi @uniofnomi.bsky.social · 02/09/2026
The degree of bias is an embarrassment for #science. Example: T. vaginalis, the most prevalent nonviral STI that disproportionately affects women everywhere. It's caused by a #parasite that's easy to see & recognize under a microscope. So why is it "neglected"? pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
Trichomoniasis: The “Neglected” Sexually Transmitted Disease
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Nonia Pariente @npariente.bsky.social · 01/09/2026
Timely issue given situations such as the one below - women's basic physiology is far from understood, chronically underfunded and understudied. This needs to change to improve health outcomes. @plosbiology.org calls for more funding & more exposure of basic research in this field plos.io/4ckiAOu
plos.io
Basic research into Women’s Health should be a priority for all
Despite recent progress in clinical research into Women’s Health, basic research is still lagging behind. This Editorial calls for a renewed focus on basic physiology research into both sexes to close the gap.
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Nonia Pariente @npariente.bsky.social · 01/09/2026
This is an issue particularly close to my heart - women's basic physiology is far from understood, chronically underfunded and understudied. This needs to change to improve health outcomes. Here @plosbiology.org calls for more funding for basic research in this area & more exposure of the results 🧪
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Nonia Pariente @npariente.bsky.social · 28/08/2026
This guy’s seen too much “For all mankind”…
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Hiten Madhani @hitenmadhani.bsky.social · 27/08/2026
Most basic science departments at UCSF are having faculty searches this year. Biochemistry & Biophysics, Microbiology & Immunology, Cellular and Molecular Pharmacology, Physiology and more. We're looking for new and exciting science and nice people. You'll find them all at aprecruit.ucsf.edu
aprecruit.ucsf.edu
Welcome - AP Recruit
University of California, San Francisco Online Faculty Recruitment
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James Briscoe @jamesbriscoe.bsky.social · 27/08/2026
Our latest: We develop a dynamical landscape modelling framework based on time resolved single-cell data Applied to neural tube fate decisions it shows cell fate decisions as flip bifurcations, a circular topology & it predicts unseen signalling regimes @plosbiology.org doi.org/10.1371/jour...
doi.org
Dynamic Landscape Analysis of cell fate decisions provides predictive models of neural development from single-cell data
Applying dynamical systems theory to single-cell data can provide a detailed picture of the cellular states observed during cell fate decisions. This study presents a dynamic landscape analysis (DLA) ...
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Nonia Pariente @npariente.bsky.social · 26/08/2026
*Is the scientific paper still a fraud?* How we write scientific papers does not reflect how we do science, argues @prof-tregoning.bsky.social This matters in the AI age because it masks the human in the process @plosbiology.org plos.io/4xn4OlZ
plos.io
Is the scientific paper still a fraud?
How we write scientific papers does not reflect how we do science, masking the human in the process by design. This Perspective invites us to consider the structure of the scientific paper, and the ne...
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Nonia Pariente @npariente.bsky.social · 26/08/2026
"The minister stated that it is “time for women to be included in agendas and health studies, and for the male body to cease being the universal reference point for everything" I'd say it is high time yes #WomenHealth
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Antonio Martínez Ron @aberron.bsky.social · 26/08/2026
ÚLTIMA HORA ‼️ Igualdad pide que se revise el estudio sobre menopausia con datos de hombres: “Esperamos que no se vuelva a repetir” www.eldiario.es/1_cd8387?utm...
eldiario.es
Igualdad pide que se revise el estudio sobre menopausia con datos de hombres: “Esperamos que no se vuelva a repetir”
La ministra Ana Redondo ha pedido la revisión del polémico trabajo sobre la alimentación en la menopausia basado en datos obtenidos en varones que ha revelado por elDiario.es. "Ya es hora de que las m...
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Nonia Pariente @npariente.bsky.social · 25/08/2026
RIP Dolly Parton
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Kristian G. Andersen @kgandersen.bsky.social · 24/08/2026
We have a (dry lab) Postdoc Position in Viral Genomics & Pathogen Surveillance here in wonderful and sunny San Diego 🏄‍♂️☀️! We're looking to continue to build our AI and broader infectious disease surveillance efforts, with a focus on our outbreak.info platform. Read more: andersen-lab.com/about/
andersen-lab.com
About | Andersen Lab
Learn more about the Andersen Lab, as well as jobs and career opportunities.
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