The authors demonstrate that KMT2B primarily regulates gene expression through LINE-1 elements with enhancer-like function, rather than by counteracting Polycomb repression, revealing an underapprecia...

Transcription factors (TFs) form dynamic, high-concentration clusters, condensates, or hubs, proposed to increase TF binding frequency at target enhancers. However, how enhancer sequence shapes hub pr...

Noncoding regulatory elements in the human genome can control gene expression through distinct mechanisms, including acting as enhancers, silencers, or topological elements. However, we lack tools to ...

The differentiation variability of human pluripotent stem cell lines is diagnosed and corrected.

Technological advances over the past decade have enabled genome-wide mapping of chromatin organization across diverse organisms at unprecedented resolution. These studies have uncovered both conserve…

Simulations integrating micro-C and imaging data provide a coherent view of chromatin organization from nucleosomes to clutches to domains, revealing that most regions form compact domains but short r...

Cyclin-dependent kinase 9 (CDK9) inhibition represents a promising therapeutic strategy in cancers that disrupts RNA polymerase II pause release and collapses oncogenic transcripts. Here, we show that...

Retrotransposons can infect neighboring cells using a mechanism that relies on a small fusogen-like protein rather than on the envelope protein that is typically required for infection.

In memoriam: Professor Timothy H. Bestor 1952-2026

In memoriam: Professor Timothy H. Bestor 1952-2026

Morphogen gradients require ligands to disperse across tissues from their sites of production, yet receptor engagement can consume ligand before it reaches distant cells. This poses a particular chall...