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Paul Villain

@paul-villain.bsky.social
56 followers 81 following 2 posts

Postdoctoral fellow in the Evolution of Molecular Systems lab in Oxford. DNA topology / chromatin / microbiology

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Reposted by Paul Villain
FragileNucleosome @fnucleosome.bsky.social · 02/10/2026
📢🧬Join us on Wednesday, Oct 7th for the next #FragileNucleosome seminar to hear exciting chromatin stories from Moonmoon and Paul! If you still haven't registered for our series: us06web.zoom.us/webinar/regi...
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Reposted by Paul Villain
Lars Eicholt @lacholt.bsky.social · 26/08/2026
Two years ago @lassemiddendorf.bsky.social and I noticed that structure and disorder predictor are discordant for de novo emerged and randomized proteins. We now identified which sequences drive these discordant predictions and what properties they have. 1/6 www.biorxiv.org/content/10.6...
biorxiv.org
A discrete protein subset drives structure prediction discordance in orphan proteins
Structure and disorder predictors are increasingly used as decision-grade tools in protein engineering and in the analysis of newly emerged proteins, yet how the current state-of-the-art behaves on se...
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Reposted by Paul Villain
Antoine Hocher @ahocher.bsky.social · 22/08/2026
Don’t know what to read on the beach tomorrow? Meet E. coli strain tabula rasa chromatina. Thought-provoking study from Toby’s lab, spearheaded by the great @paul-villain.bsky.social. What’s a chromosome without chromatin? Grateful to have been part of this project. 🚀🚀 as they say on LinkedIn
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Reposted by Paul Villain
Tobias Warnecke @tobiaswarnecke.bsky.social · 22/08/2026
Who needs chromatin anyway...? NOT THIS GUY! www.biorxiv.org/content/10.6... 1/n
biorxiv.org
Chromatin is dispensable for bacterial life
Inside cells, DNA is intimately associated with proteins, forming chromatin. The protein constituents of chromatin vary across the tree of life: histones are the principal building blocks of chromatin...
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Paul Villain @paul-villain.bsky.social · 24/08/2026
Delighted to finally share the preprint on this crazy project! Deleting all the major NAPs of E. coli is viable. The strain, while fragile, grows surprisingly well. But, what happens with transcription, genome compaction, genome organisation...? Find out here: www.biorxiv.org/content/10.6...
biorxiv.org
Chromatin is dispensable for bacterial life
Inside cells, DNA is intimately associated with proteins, forming chromatin. The protein constituents of chromatin vary across the tree of life: histones are the principal building blocks of chromatin...
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Reposted by Paul Villain
PLOS Biology @plosbiology.org · 22/05/2025
#Bacteria use weapons to outcompete rivals, but what happens if they're transferred? @prokaryota.bsky.social @jdpal.bsky.social &co show that HGT of toxin #plasmids is rare but recipients can thrive under relaxed nutrient competition, reshaping bacterial warfare @plosbiology.org 🧪 plos.io/43vC3X7
 Modeling predicts that metabolic diversity increases the ecological impacts of weapon gene transfer. Modeling scenarios for each column are shown across the top row. Bottom row: Example dynamics of the strains (attacker, target, transconjugant) during a contest using parameters that correspond to the cross (X) shown in the parameter sweeps directly below.
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Reposted by Paul Villain
Tobias Warnecke @tobiaswarnecke.bsky.social · 11/04/2025
Join us in Catalonia to discuss chromatin evolution across the tree of life and from all angles (metabolism, synthetic chromatin, you name it!) meetings.embo.org/event/24-evo...
meetings.embo.org
EvoChromo: Evolutionary approaches to research in chromatin
Chromatin is the complex of DNA, RNA and protein that is found making up the chromosomes in eukaryotic cells. Chromatin is essential for proper genome function and is involved in chromosome segregati…
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Reposted by Paul Villain
Antoine Hocher @ahocher.bsky.social · 22/04/2025
Excited to announce the EMBO Conference: Molecular Biology of Archaea (MBoA) 2026! Join us in Cambridge, UK, from 6–10 July 2026 for the only international meeting dedicated entirely to Archaea.
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