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Pranav NM Shah

@proteincapsid.bsky.social
489 followers 253 following 81 posts

Postdoc at STRUBI. Using cryo-EM to see viruses better.

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Reposted by Pranav NM Shah
Lorna Malone @drlornamalone.bsky.social · 28/09/2026
We’re delighted to welcome participants from around the world for Day 1 of the Wellcome-MRC in situ Cryo-ET Workshop at @diamondlightsource.bsky.social and @astburycentre.bsky.social Welcome everyone! 🧊🔬 #CryoET #CryoEM #InSituCryoET #StructuralBiology #DiamondLightSource
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Basil Greber @bjgreber.bsky.social · 28/09/2026
This further highlights the risks of using tools that were created by companies who were, well, "not very selective" with how they sourced the information required to develop their models. It is becoming increasingly unlikely that users of these tools are being treated any differently.
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Claudia Alen Amaro @claudialen.bsky.social · 25/09/2026
Today I am @diamondlightsource.bsky.social to celebrate the great contribution of Dave Stuart to Diamond and the structural biology community @walshdls.bsky.social starts the symposium with key highlights For @instruct-eric.bsky.social his vision was instrumental personally I can only say thank you!
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Cathy Spangler @cathyspangler.bsky.social · 22/09/2026
I'm excited to share our new preprint, where we show that fine-tuning gold nanoparticle conjugation to different Fab structural elements can produce powerful, rigidly coupled, labeling tools for in-situ cryo-ET. Take a look if you want to see an AuNP in an EM map!🔬🧠 www.biorxiv.org/content/10.6...
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Martin Pacesa @martinpacesa.bsky.social · 21/09/2026
And ʙɪɴᴅᴄʀᴀꜰᴛ2 is for everyone: we've teamed up with @adaptyv.bio, AriaX Bio & Tamarind Bio to host it, so anyone can run it without a GPU. Built by @erikmaeots.bsky.social, @liza-ch.bsky.social , Leonardo Tredese & Jan Dernic. Special thanks to @sokrypton.org & Lennart Nickel. 🚀
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Daniel Hurdiss @danielhurdiss.bsky.social · 21/09/2026
Excited to share that our norovirus NS3 study is now online in Nature Communications! 🎉 These enzymes, found across an entire order of RNA viruses, have long been molecular motors in search of a function. We think we’ve uncovered their role. (🧵) www.nature.com/articles/s41... #virology #cryoEM
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Alan Brown @alanbrownhms.bsky.social · 10/09/2026
Millions of beating cilia keep airways clean. At the base of each is the transition zone (TZ), a gate that controls which proteins enter and leave. In our paper out today in Science, we used cryo-FIB-ET to image the TZ inside human airway cells www.science.org/doi/10.1126/...
science.org
In situ structure of the human ciliary transition zone links linker defects to primary ciliary dyskinesia
The ciliary transition zone (TZ) regulates ciliary proteome composition, yet its molecular architecture, protein content, and contribution to motile ciliopathies remain poorly defined. We applied in situ cryo-electron tomography and subtomogram averaging ...
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Ricardo D. Righetto @lifeonthewedge.bsky.social · 08/09/2026
A wild publishing ride to get here... but finally! (first bioRxiv: January 5th, 2024 🙃) Amazing work from @lorenzlamm.bsky.social and colleagues 🤗 Special thanks to the community who jumped early on the boat, sharing feedback and training data to make MemBrain v2 a reality 🙏🏽
nature.com
MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomography - Nature Methods
MemBrain v2 enables streamlined analysis of membranes in cryo-electron tomography by providing user-friendly tools for membrane segmentation, membrane protein localization and spatial analysis, suppor...
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Abraham lab at Harvard Medical School @abrahamlabhms.bsky.social · 25/08/2026
We are excited to share our new @biorxivpreprint.bsky.social examining the structural basis for receptor binding by two flaviviruses 🤩: www.biorxiv.org/content/10.6... @harvardmicro.bsky.social @harvardvirology.bsky.social @hhmi-science.bsky.social
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Pranav NM Shah @proteincapsid.bsky.social · 18/08/2026
What a fantastic piece of prose! nautil.us/what-makes-h...
nautil.us
What Makes Humans Stupid
What Makes Humans Stupid: It takes intelligence to get things spectacularly wrong. An essay on our undoing.
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Daniel Hurdiss @danielhurdiss.bsky.social · 13/08/2026
Induction of neutralising antibodies against conserved rhinovirus capsid protein VP4 is dependent on presentation of VP4 peptide immunogens in a virus-like conformation dx.plos.org/10.1371/jour...
dx.plos.org
Induction of neutralising antibodies against conserved rhinovirus capsid protein VP4 is dependent on presentation of VP4 peptide immunogens in a virus-like conformation
Author summary Rhinoviruses (RVs) are highly prevalent respiratory viruses that frequently cause common cold symptoms. For people with chronic lung disease such as asthma, infection can cause signific...
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Daniel Hurdiss @danielhurdiss.bsky.social · 30/07/2026
One month left to apply (deadline August 31st)! 👇 #Virology #AcademicJobs #FacultyJobs #FacultyPosition #TenureTrack #GroupLeader
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Miguel Hernandez Gonzalez @miguel-virus-cells.bsky.social · 29/07/2026
Great to see this finally published! We describe channels at the poxvirus core wall involved in nucleic acid release. www.nature.com/articles/s41...
nature.com
In situ structure of the poxvirus portal complex - Nature
Cryo-electron tomography uncovers the structure of a conserved hexameric ‘portal complex’ that spans the core wall in vaccinia virus, and shows how it is associated with viral functions such as a...
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Abraham lab at Harvard Medical School @abrahamlabhms.bsky.social · 30/07/2026
We are excited to share two preprints reporting a mosquito-specific receptor for chikungunya virus and other alphaviruses! 🤩 www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6... @harvardmicro.bsky.social @harvardvirology.bsky.social @hhmi-science.bsky.social
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Da-Neng Wang @danengw.bsky.social · 28/07/2026
Congratulations to Chris Russo, MRC Laboratory of Molecular Biology, for receiving the 2026 K.H. Kuo Award for Distinguished Scientist in Biological Electron Microscopy www.bsc.org.cn/KuoSymposium...
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Wilfling Lab @wilflinglab.bsky.social · 13/01/2026
We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉
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Bui Lab @McGill @builab.bsky.social · 20/07/2026
Interested in 3D-printed models of cryo-EM grids, autogrid and cryo-FIB for visual teaching/decoration. Download our model and print: makerworld.com/en/models/30... Designed in Blender by Khan Bao, an undergrad in the lab.
makerworld.com
Cryo-EM Grids for Teaching - Free 3D Print Model - MakerWorld
Download this free 3D print file designed by CiliaBuilder. EM Grid Scaled ModelScaled up and simplified 3D model of EM grids and autogrids for demonstration of preparation process and milling. Content...
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EMBL @embl.org · 20/07/2026
EMBL and University of Washington researchers have developed NovoTags – AI-designed protein tags – that in future could help researchers combine fluorescence microscopy and cryo-ET, helping identify individual proteins inside cells. @steffenklein.bsky.social More info 👉 www.embl.org/news/science...
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Rasmus Jensen @rasmusjensen.bsky.social · 23/06/2026
Great new study from Veijo! Using cryoET, cell biology and molecular dynamics simulations to show how seipin switches from a closed to an open conformation that defines the ER–lipid droplet connection and drives lipid droplet growth.
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Mark Frank @markfrankbio.bsky.social · 16/06/2026
The tutorial I am going through is quite excellent and was featured at the 2026 Michigan workshop. You can find it here: subtomo.readthedocs.io/hiv/setup/
subtomo.readthedocs.io
Setup - Subtomo
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Ben Barad @baradlab.com · 13/06/2026
I had such a fun time teaching at the U Michigan Cryo-ET Course this week! I taught quantitative ultrastructure analysis and we made cool figures like these! My course materials are at baradlab.com/michigan_tutorial for anyone to try. Workflow include mesh refinement and thickness measurement!
ChimeraX/ArtiaX visualization showing mitochondria-associated ribosomes connecting drives reduced IMM-OMM spacing in yeast.Surforama depiction of mitochondrial outer membrane shows membrane-associated ribosomes.
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Emmottlab @emmottlab.bsky.social · 01/06/2026
In other lab news, Ed was promoted to Professor of Virology & Proteomics. Huge thanks to the team for all their work and support! And to the various mentors and supporters who have helped along the way. We have lots more exciting science coming in the near future!
Staff page for Ed Emmott, with new Professor of Virology & Proteomics title.
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Daniel Hurdiss @danielhurdiss.bsky.social · 29/05/2026
Honoured to receive the first Sir Dave Stuart Early Career Award today. Dave was my PhD external examiner, making this award, recognising his contributions to structural biology, especially meaningful to me. Thank you to Instruct-ERIC and Thermo Fisher Scientific for championing ECRs.
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Pranav NM Shah @proteincapsid.bsky.social · 28/05/2026
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Allegretti Lab @matteoall.bsky.social · 27/05/2026
We're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 26/05/2026
Led by Hannah Ochner, @tbharat-lab.bsky.social’s group have developed correlated #cryoEM & mass spectrometry imaging, capable of sub-cellular chemical mapping. With @kiranrpatil.bsky.social’s group, they have imaged the cellular uptake of forever chemicals. mrclmb.ac.uk/news-events/... #LMBResearch
Diagram showing cryo-FIB-SIMS technique
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Rémi Fronzes @fronzeslab.bsky.social · 26/05/2026
New preprint. In S. sanguinis, a C5a peptidase-like protease (ScpH) polymerizes along eDNA, turning it into a catalytic biofilm scaffold. Great work from @robinanger.bsky.social in our lab, with Pelicic lab @lcbofficiel.bsky.social www.biorxiv.org/content/10.6...
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Briggs Group @briggsgroup.bsky.social · 18/05/2026
The architecture of carriers formed by AP3:ARF1 for lysosomal membrane protein transport: www.science.org/doi/10.1126/.... Work from @jggkaufman.bsky.social, in collaboration with @dgershlick.bsky.social and David Owen. @mpibiochem.bsky.social @thecimr.bsky.social
science.org
Architecture of clathrin-independent AP3:ARF1-coated carriers
AP3 generates clathrin-free carriers on endosomes by organizing via ARF1 dimers into elongated membrane-deforming arrays.
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Lorna Malone @drlornamalone.bsky.social · 19/05/2026
📢 Cryo Lift-Out commissioning call now open (eBIC) 🗓 Apply by 05 Aug 2026 for experimental access Oct 2026 – Apr 2027 ⚙️ Aquilos CryoFIB @diamondlightsource.bsky.social 🎥 Join our webinar for more info + ask questions 👇 🗓 22 May | 11:00 BST 🔗 bit.ly/cryo-Lift-Out 🔐 498563 #CryoEM #CryoET #CryoFIB
Join our Cryo-Lift Out Webinar
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The Guardian @theguardian.com · 13/05/2026
France confines more than 1,700 people to cruise ship over suspected norovirus death
theguardian.com
France confines more than 1,700 people to cruise ship over suspected norovirus death
One elderly passenger on vessel docked in Bordeaux has died and about 50 people have symptoms, say officials French authorities have confined more than 1,700 passengers and crew members on a cruise ship docked in Bordeaux after a passenger died from suspected norovirus, officials have said. The Ambassador Cruise Line vessel carrying 1,233 passengers, most of them British or Irish, arrived in Bordeaux on Tuesday. One 90-year-old passenger had died and about 50 people had shown symptoms of the virus, French health officials said. Continue reading...
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David Bhella @dbhella.bsky.social · 11/05/2026
Amazing work from Charlotte Lewis - our latest preprint describes structure guided development of an antiviral peptide, targeting VP2 portal assembly - a strategy that may have broad application to treat or prevent calicivirus disease. www.biorxiv.org/content/10.6...
biorxiv.org
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Hanjin Liu @liu-hanjin.bsky.social · 09/05/2026
Job navigation in table view, searchable tags, 3D mesh optimized for masks, and many more features! 👉👉👉 github.com/hanjinliu/hi... Let's make our RELION directory a better place.
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Dimitry Tegunov @dtegunov.bsky.social · 03/05/2026
We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:
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Gregor Weiss @weiss-lab.bsky.social · 28/04/2026
If you wanna try our new Autogrid High-Pressure Freezing Planchettes ❄️ - you can use the provided drawings & CAD files to produce them in-house 🛠️ - you can now also contact www.wohlwend-hpf.ch to order yours with a shiny gold-coating ✨ The preprint for instructions ➡️ www.biorxiv.org/content/10.6...
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Pranav NM Shah @proteincapsid.bsky.social · 26/04/2026
Industrious beeings of spring
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Helena Watson @helenawatson.bsky.social · 25/04/2026
Preprint 🧵! I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition! BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a www.biorxiv.org/content/10.6... (1/6)
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bioRxivpreprint @biorxivpreprint.bsky.social · 24/04/2026
Interleaved multi-magnification cryo-electron tomography bridges cellular and structural biology www.biorxiv.org/content/10.64898/20…
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Daniel Hurdiss @danielhurdiss.bsky.social · 23/04/2026
Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells www.nature.com/articles/s41...
nature.com
Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells - Nature
Human CEACAM6, which is widely expressed in the lung, is identified as a receptor used by the spike proteins of Cardioderma cor (heart-nosed bat) alphacoronaviruses to enter cells.
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cryoEM papers @cryoempapers.bsky.social · 09/04/2026
Cetacean coronavirus spikes highlight S glycoprotein structural plasticity pubmed.ncbi.nlm.nih.gov/41950284/ #cryoEM
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Pranav NM Shah @proteincapsid.bsky.social · 03/04/2026
Van Gogh Starry night is hypnotising... but this hits on a different level...
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cryoEM papers @cryoempapers.bsky.social · 28/03/2026
The low-density lipoprotein receptor LDLR mediates cellular entry of nonenveloped hepatitis A virus pubmed.ncbi.nlm.nih.gov/41894341/ #cryoEM
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Grant Sanderson @3blue1brown.com · 22/03/2026
This video was a complete joy to make. Here's a short preview, but next time you're looking to sit down for 45 minutes of math and art, take a look at the full version on YouTube: youtu.be/ldxFjLJ3rVY
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Elodie Carmen Leroy @ecleroy.bsky.social · 19/03/2026
🚨 Preprint alert! We solved the structure of human NSUN2 bound to Asp tRNA, revealing how it installs m⁵C and recognizes RNAs #CryoEM #RNABiology A collab between Casañal & Gullerova labs, with @miclass.bsky.social and me working side by side as co-first authors 🔗 doi.org/10.64898/202... (0/7🧵)
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Ben Engel @cellarchlab.com · 19/03/2026
Stoic 🦾 from our shared student @daniil-litvinov.bsky.social predicts protein complex stoichiometry. A fun collab with @ninjani.bsky.social @torstenschwede.bsky.social - this #AI adventure beyond our core #CryoET methods was made possible by the @biozentrum.unibas.ch PhD Fellowship Program! 🧪 🧶🧬
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Pranav NM Shah @proteincapsid.bsky.social · 09/03/2026
Did you see this post think “Oh damn! I have this really cool story but not enough time to submit!”. Well we heard you! And extended the deadline to 30.03.2026! Send your abstracts in for a chance to present in Autumn!
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Pranav NM Shah @proteincapsid.bsky.social · 08/03/2026
If you have computational and physics chops go work with @bforsb.bsky.social . You will mot be disappointed!
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John Rubinstein @johnrubinstein.bsky.social · 06/03/2026
I've written a review on what I think is an extremely exciting direction in cryo-EM: Cryo-EM of endogenous membrane proteins in their native lipid bilayer Open access in Quarterly Reviews of Biophysics: doi.org/10.1017/S003...
Figure 1. Cryo-EM of abundant protein complexes in native membranes.Figure 2. Cryo-EM of membrane proteins in vesicles.Figure 3. 3D reconstruction of V-ATPase in native synaptic vesicle membranes.Figure 4. Generation of membrane vesicles for structure determination of proteins in their native lipid bilayer.
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SwiftOnSecurity @swiftonsecurity.com · 02/03/2026
Remember that everyone you meet is fighting their own battle, sometimes with amino acids
I fucking hate proline so fucking much it's the worst amino acid it's so fucking stupid it's incapable of being fucking normal so it forms an ugly ass ring with itself with its own fucking nitrogen cuz it's a loser fucking amino acid I hate it so much I'd rather cut off my right tit than have to ever draw a mechanism with proline ever again
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Pranav NM Shah @proteincapsid.bsky.social · 03/03/2026
Abstract submission closes this Friday. If you have a story to tell and have just seen this do apply! @dbhella.bsky.social and myself look forward to your abstracts!
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Florian Schur @schurlab.bsky.social · 02/03/2026
The deadline for applying to the open postdoc position in our lab is coming up! Reach out if you have questions about the project, our lab and ISTA!
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