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Elodie Carmen Leroy

@ecleroy.bsky.social

116 followers 233 following 13 posts

EMBO postdoctoral fellow in the group of Ana Casañal (Human Technopole, Milan, Italy). RNA & pet lover.

Elodie Carmen Leroy @ecleroy.bsky.social · 21/09/2026

How can a single antibiotic halt translation across all domains of life? 🧬 Our new study in Nucleic Acids Research reveals how Sparsomycin traps active ribosomes through a conserved mechanism. academic.oup.com/nar/article/... #Ribosome #Translation #StructuralBiology #Antibiotics #RNA #iTPseq

Graphical representation of the T. thermophilus 70S ribosome showing the 30S and 50S subunits, mRNA, and P-site tRNA. Sparsomycin (yellow) binds in the peptidyl transferase center at the interface between the A and P sites. The enlarged view shows sparsomycin occupying the A-site cleft adjacent to the P-site fMet-tRNA, closely contacting its 3′ CCA end (C74, C75 and A76) and the attached fMet.

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Elodie Carmen Leroy @ecleroy.bsky.social · 19/03/2026

🚨 Preprint alert! We solved the structure of human NSUN2 bound to Asp tRNA, revealing how it installs m⁵C and recognizes RNAs #CryoEM #RNABiology A collab between Casañal & Gullerova labs, with @miclass.bsky.social and me working side by side as co-first authors 🔗 doi.org/10.64898/202... (0/7🧵)

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