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Nearly a quarter of the proteins encoded in most organisms are transmembrane proteins. Contrary to textbook description, many feature a hydrophilic gr…

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Bridge-like lipid transfer proteins (BLTPs) are established to function in phospholipid transport between bilayers at organelle–organelle contact s...

Elhan et al. show that ATG2A acts with DGAT2, the enzyme producing triacylglycerol (TAG), in lipid droplet growth. By delivering diacylglycerol to lipid droplets, ATG2A not only fuels TAG production b...

Zhao et al. identify the molecular machinery for lipid droplet motility, consisting of the type V myosin Myo2, the Myo2 adaptor protein Ldm1, and its surface receptor Ldo16. They uncover a molecular l...

Lipid droplets (LDs) originate from the endoplasmic reticulum (ER) and are unique among cellular organelles, as they consist of a hydrophobic core of neutral lipids that is surrounded by a phospholipi...

Spatiotemporal information on ferroptosis progression is highly desired to develop new therapies. Now, the development of organelle-targeting fluorogenic radical-trapping antioxidants has enabled dissection of the dynamic subcellular evolution of ferroptosis through real-time live-cell fluorescence imaging.

Ferroptosis, a regulated form of cell death driven by excessive lipid peroxidation, has emerged as a promising therapeutic target in cancer. Ferroptosis suppressor protein 1 (FSP1) is a critical regul...

Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. Deficienci...

Nature Cell Biology - Creating clear and engaging scientific figures is crucial to communicate complex data. In this Comment, I condense principles from design, visual perception and data...

FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...