Summary: The nucleus–vacuole junction is a prominent contact site linking the nuclear ER and the yeast vacuole. We highlight the physiological implications and metabolic plasticity of this unique orga...

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Zhao et al. identify the molecular machinery for lipid droplet motility, consisting of the type V myosin Myo2, the Myo2 adaptor protein Ldm1, and its surface receptor Ldo16. They uncover a molecular l...