A tandem fluorescent mCherry–EGFP–LC3 reporter enables live-cell visualisation of autophagy–lysosome dynamics in naked mole-rat skin fibroblasts. Chloroquine-induced lysosomal stress promotes accumul...

Type II NADH dehydrogenases (NDH-2) are widespread bacterial enzymes involved in cellular redox homeostasis. Combining ancestral sequence reconstruction, biochemistry and molecular dynamics, we show ...

θ-CA3 from a marine diatom has an N-terminal transmembrane helix and two homologous catalytic domains. The enzyme functions as a dimer, with active sites formed near the dimer interface. A bicarbonat....

Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple-negative breast cancer cells, lipid droplets (LDs) sequester dietar...

IRE1 is an ER stress sensor that restores protein homeostasis through two signaling activities: XBP1s, which upregulates its target gene expression or RIDD which downregulates its target transcripts....