Lipids generated by oxidative stress and their effects on immunity and cancer are reviewed.

Mitochondrial tricarboxylic acid (TCA) cycle metabolites have emerged as critical regulators of immunity and inflammation beyond their canonical metab…

Innate immune recognition of bacteria is thought to center on cell-surface or endosomal pattern recognition receptors such as TLRs. Ragland et al. identify an intraphagosomal cyclic dinucleotide (CDN)...

A preprint by Lunger et al. reports macrophage engineering through constitutively active synthetic cytokine receptors to induce polarization states that are unobtainable with natural cytokine receptor...

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information: Proposal to Cap the Number of Simultaneous Research Project Grants per Principal Investigator ...

Nature Reviews Rheumatology - In this Review, the authors discuss novel approaches to improving the functional classification of variants of uncertain significance that are associated with systemic...

Nature Immunology - Jena, Qu et al. show that mannadjuvant, a formulation of fungal mannan and aluminum hydroxide, increases the magnitude, durability and breadth of the response elicited by...

Efficacious immune responses require the coordinated encounter of rare antigen-specific adaptive lymphocytes with their cognate innate antigen-present…

Author summary The immune system uses specialized sensors called inflammasomes to detect infection and trigger protective responses. These responses are carried out by enzymes known as caspases, which...

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imageimageNINJ1 blocks HSV-1 entry into mouse macrophages independent of its role in cell death, resulting in greater secretion of pro inflammatory cytokines downstream of infection. Mouse macrophages lacking NINJ1 are more permissive to HSV-1 ...

Acetyl-coenzyme A functions as a non-canonical signal to trigger mitophagy, and the acetyl-coenzyme A–NLRX1 axis underlies the KRAS-inhibitor-induced mitophagy response and promotes drug resistan...

The NLRP3 inflammasome plays a central role in host defense against microbial infections but also contributes to inflammatory diseases. Functioning of…

Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...

The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...

Damage-associated molecular patterns (DAMPs) are self-derived molecules released during tissue damage that influence immune responses. Phospholipids, essential to cell membranes and lung surfactants, ...

imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1 (CASP1), which complicates interpretation of results in functional studies and limits their clinical potenti...

Upon pathogen detection, phagocytes trigger immunity. This process induces tissue stress and the formation of host-derived molecules that further tune immune responses. We show that host-derived oxidi...

Shivcharan et al. report that endosomal damage sensing by the danger receptor galectin-8 licenses noncanonical inflammasome activation and pyroptosis during intracellular bacterial infections in human...

The innate immune system senses bacterial pathogens by employing pattern recognition receptors that detect pathogen-associated molecular patterns (PAMPs) and guard proteins that monitor pathogen disru...

Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune surveillance mechanism in the nu...

NLRP3 inflammasome activation is critical for the induction of protective immunity, but molecular insights are still lacking. Here, the authors express NLRP3 variants targeted to different cellular lo...

Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...

TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.

Examination of immunological changes in transgender individuals undergoing gender-affirming testosterone treatment reveals sex hormone-regulated pathways in humans and explains sex-divergent responses...

Mammalian cells present RNA-binding proteins on the cell surface that form clustered domains containing glycoRNAs.

Cell biology; Functional aspects of cell biology

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...