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Proteases and Innate immunity lab @ York

@protinnimmunity.bsky.social
1.6K followers 1.3K following 21 posts

Immunology lab led by Dr. Dave Boucher, Unravelling how proteases control innate immune responses to infections and diseases Boucherlab.org

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Proteases and Innate immunity lab @ York @protinnimmunity.bsky.social · 29/04/2026
Happy #dayofimmunoloy! We work hard to understand how our immune system protects us from infection! Thanks to @ukri.org @yorkshirebiodtp.bsky.social MRC and BBSRC to support our research and the development of novel therapies!
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Gunnar N. Schroeder @gunnarns.bsky.social · 24/04/2026
The 2026 UK Cellular Microbiology Network Meeting is approaching fast! Submit an abstract until May, 12th and join us June, 22nd/23rd in Belfast! Exiting keynote speakers and opportunities for early career researchers from the UK, Ireland and beyond to share their work. www.ukcellmicro.org
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Itai Yanai @itaiyanai.bsky.social · 29/12/2025
With all the excitement about AI giving us answers, we often forget that the real trick is to figure out what is the question.
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Annika Hausmann @hausmannannika.bsky.social · 11/11/2025
Jo in our team - we are looking for a PhD student, postdoc or lab manager! More information and links to job portal for application submission: lnkd.in/dcU2Vg7W lnkd.in/dgVKTARV Please share widely 🙏🏼 @yefis-immunology.bsky.social @syis-ecr.bsky.social
lnkd.in
Postdoc or PhD student position in molecular dissection of cellular crosstalk in the intestinal mucosa
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Proteases and Innate immunity lab @ York @protinnimmunity.bsky.social · 10/11/2025
Correct link: www.findaphd.com/phds/?Keywor...
findaphd.com
dave boucher PhD Projects, Programmes & Scholarships - 3 PhDs Listed
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in dave boucher. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
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Proteases and Innate immunity lab @ York @protinnimmunity.bsky.social · 10/11/2025
3 PhD positions in the lab for British Students. Inflammasome, cell death and skin immunity, with fantastic colleagues. Check them out or share it with curious and motivated PhD students: www.findaphd.com/phds/?Keywor... @yorkshirebiodtp.bsky.social @ybri-uoy.bsky.social @biologyatyork.bsky.social
findaphd.com
dave boucherare PhD Projects, Programmes & Scholarships
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in dave boucherare. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
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Daniela Barillà @danielabarilla.bsky.social · 09/11/2025
📢 Interested in #chromosomes 🧬 & #archaea thriving at the edge of life? PhD project in York,UK on how archaea pass on their genome to daughter cells.Friendly supervisors: me, @steve-quinn-lab.bsky.social & @georgerheath.bsky.social www.findaphd.com/phds/project... 📅 January 7, 2026 Please RP🙏thx!
Archaeal cells whose DNA has been stained with a blue dye. Zoomed-in images of mutant cells that display chromosome segregation defects.High-resolution images of DNA-protein complexes obtained with atomic force microscopy. Upon binding, the protein bridges distant sites, forming loops.
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Proteases and Innate immunity lab @ York @protinnimmunity.bsky.social · 03/11/2025
New story from the lab by PhD student Seb Grant. Started as a summer project and developed into an interesting story. www.biorxiv.org/content/10.1...
biorxiv.org
Evolutionary convergence of a Pyroptosis-Apoptosis crosstalk drives non-canonical inflammasome signalling.
The coordination of efficient immune responses to infections is essential to enable pathogen clearance and host survival. Cell death modalities are a crucial component of the innate immune system and ...
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The Powrie Lab @powrielab.bsky.social · 29/10/2025
Interested in joining the Powrie Lab? We’re looking for a Postdoctoral Researcher to study the neutralisation capacity of human anti-IL-10 autoantibodies. You’ll be part of our new MRC CoRE in Exposome Immunology!🧫🦠 Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
bulletin.ndorms.ox.ac.uk
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Sabrina Sofia Burgener @s-burgener.bsky.social · 21/10/2025
🔔 Chech out this new cool story on non-canonical inflammasome signaling in NK cells by @protinnimmunity.bsky.social
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UK Cellular Microbiology @ukcellmicro.bsky.social · 06/10/2025
SAVE THE DATE! The 2026 UK CellularMicrobiologyNetwork meeting will be held 22nd - 23rd of June at @wwiem-qub.bsky.social in Belfast. Researchers from the UK and beyond are invited to share exciting work on the mechanisms of host-pathogen interactions. Follow us to stay tuned! www.ukcellmicro.org
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Broz Lab @brozlab.bsky.social · 02/10/2025
The second day of the @dib-unil.bsky.social #PRR symposium kicks off with more excellent talks including our own Jakub Began.
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Avinash Shenoy @avishenoy.bsky.social · 28/09/2025
📢A new effector-triggered immunity role for GBP1! No place for pathogens to hide now that GBP1 can detect extracellular pathogens that hijack the actin cytoskeleton. Surprise*suprise* GBP1 does this independently of LPS! 🧵 biorxiv.org/content/10.1...
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Adrian Liston @labliston.bsky.social · 19/09/2025
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
currentprotocols.onlinelibrary.wiley.com
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Proteases and Innate immunity lab @ York @protinnimmunity.bsky.social · 11/09/2025
Ready to start 2 days of everything innate immunity and inflammation #bsiinflammation2025 @britsocimm.bsky.social
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Pablo Pelegrin @ppelegrin.bsky.social · 07/09/2025
Looking for passionate candidate to apply to PhD fellowship to University of Murcia call: www.um.es/documents/d/... Interested students contact me!
um.es
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Ivan Zanoni @lozanzi.bsky.social · 03/09/2025
#MycobiotaPower! Exciting work @nature.com by Behnsen, Jaswal &co showing that #Salmonella uses type 3 secretion system to hijack #Candida_albicans to produce arginine in the gut, boosting Salmonella infectivity & reducing the immune response! www.nature.com/articles/s41...
nature.com
Commensal yeast promotes Salmonella Typhimurium virulence - Nature
Commensal Candida albicans enhances the virulence and dissemination of Salmonella enterica subsp. enterica serovar Typhimurium.
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Dr Rebecca Coll @colllab.bsky.social · 02/09/2025
So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.
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Proteases and Innate immunity lab @ York @protinnimmunity.bsky.social · 01/09/2025
Still time to register for the BSI inflammation meeting 2025! Don’t miss out on this fantastic meeting !.
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Proteases and Innate immunity lab @ York @protinnimmunity.bsky.social · 03/08/2025
10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling - Journal of Biological Chemistry www.jbc.org/article/S002...
jbc.org
10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling
Caspases are a family of cysteine proteases conserved across all multicellular life which play critical functions that range from cell death, inflammation and cellular differentiation. Caspases cleave...
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Department of Biology, University of York @biologyatyork.bsky.social · 22/07/2025
(1/3) We've been catching up with our GenerationResearch students so far this summer..! "Hi, I am Naomi, a Biomedical Sciences student going into the final year of my Integrated Masters at York. I am currently doing my Generation Research studentship in Dave Boucher's Lab.
Naomi after a successful Western blot!
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British Society for Immunology @britsocimm.bsky.social · 15/07/2025
🔥 Last call! Today’s the FINAL day to submit your abstract for “Innate immunity & inflammation: UK inflammation 2025.” Don’t miss your chance to get involved! Submit now and join leading experts this September in Manchester. Event & submission info: bit.ly/43q9x9r
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Proteases and Innate immunity lab @ York @protinnimmunity.bsky.social · 07/07/2025
Still time to register to the next BSI Innate Immunity and Inflammation meeting. Join us for 2 days packed with great science and networking opportunities!
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Proteases and Innate immunity lab @ York @protinnimmunity.bsky.social · 07/07/2025
Still time to register to the next BSI Innate Immunity and Inflammation meeting. Join us for 2 days packed with great science and networking opportunities!
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British Society for Immunology @britsocimm.bsky.social · 18/06/2025
Congratulations to the winner of the 2025 BSI Outstanding Leadership Award, sponsored by @ceijournal.bsky.social … Professor Clare Bryant, @clarebryant.bsky.social
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Proteases and Innate immunity lab @ York @protinnimmunity.bsky.social · 28/05/2025
Interested in innate immunity and inflammation? Join us in September for a great meeting! Superb lineup of speaker and lots of opportunities for Ecrs to present!
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Rebsamen Lab @UNIL @rebsamenlab.bsky.social · 01/05/2025
Interested in #InnateImmunity ? Register now to secure your spot — abstracts can be submitted later! More info: wp.unil.ch/immunobiolog... #ImmunoSky
wp.unil.ch
Symposium immunobiology
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Proteases and Innate immunity lab @ York @protinnimmunity.bsky.social · 01/05/2025
Great work by the @inflammasomelab.bsky.social @s-burgener.bsky.social and colleagues showing in vivo the importance of caspase-1 inactivation in controlling inflammation! Impressive amount of work behind it, glad to see this out! www.biorxiv.org/content/10.1...
biorxiv.org
Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases
Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...
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Dimitris Lagos @dimitrislagos.bsky.social · 22/04/2025
We have a 3-year PDRA post in Cancer Immunogenomics. Ideal to use and strengthen your bioinformatics skills to discover how cancer transcriptome quirks shape immunotherapy outcomes. Funded by @cancerresearchuk.org. It’ll be fun! jobs.york.ac.uk/vacancy/rese... @hyms.ac.uk @ybri-uoy.bsky.social
jobs.york.ac.uk
Jobs - The University of York
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Eva Frickel @frickellab.bsky.social · 13/04/2025
🔥 Open postdoc position in human inflammation-driven control of infection! 🔥 Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5) Please share!
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Gunnar N. Schroeder @gunnarns.bsky.social · 11/03/2025
Funded 4-year #PhD in the exciting BBSRC NILAB program. @wwiem-qub.bsky.social Receive multidisciplinary training, develop #infection models and #AI image analysis to reveal bacterial & viral disease mechanisms & discover new antimicrobials. Fight #AMR Get in touch! Details: tinyurl.com/e5k6ptua
tinyurl.com
Using AI-driven computer vision and high-throughput multiplexed human cell infection assays to dissect intra- and intercellular signalling networks and discover new antimicrobials at Queen’s Universit...
PhD Project - Using AI-driven computer vision and high-throughput multiplexed human cell infection assays to dissect intra- and intercellular signalling networks and discover new antimicrobials at Que...
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JelenaBezbradicaLab @jelenalab.bsky.social · 07/03/2025
The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...
science.org
TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways
TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.
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uofytechs.bsky.social @uofytechs.bsky.social · 05/03/2025
#job 🚨for a laboratory technician in the Wright group within dept. Biology/HYMS and @ybri-uoy.bsky.social to work on creating genome-scale arrays of human cell surface receptors to discover new host-pathogen interactions. Apply by 20/3/2025: jobs.york.ac.uk/vacancy/labo...
jobs.york.ac.uk
Jobs - The University of York
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uofytechs.bsky.social @uofytechs.bsky.social · 07/03/2025
#job - INTERNAL candidates only. Technician in dept. Biology in @billgrey.bsky.social lab studying how the proteome evolves from healthy haematopoietic stem cell to malignant leukaemic stem cell in vivo. Apply by 12/3/25 jobs.york.ac.uk/internal/vac...
jobs.york.ac.uk
Jobs - The University of York
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Daniela Barillà @danielabarilla.bsky.social · 04/03/2025
Can I tempt some young minds to consider Old York for a PhD? Some days left to apply. Open to applicants WORLDWIDE 🌎.
River Ouse at sunset with some orange light on the horizon.
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Sebastian Greenhough @sebgreenhough.bsky.social · 28/01/2025
We’re currently recruiting for a biochemist, to be based here in Glasgow at the @cruk-si.bsky.social or otherwise down in Cambridge. Take a look, and obviously choose Glasgow! cancerresearchuk.wd3.myworkdayjobs.com/en-US/Extern...
cancerresearchuk.wd3.myworkdayjobs.com
Principal Scientist (Biochemistry/Enzymology)
4,000 professionals, 0 days wasted, 1 incredible purpose. Together, we are beating cancer. Principal Scientist – Biochemistry/Enzymology Starting salary: From £50,400-£57,400 per annum depending on ex...
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Daniel Mucida @danmucida.bsky.social · 02/02/2025
Great piece on circular/green labs (sent by @cyrilpedia.bsky.social). More urgent than ever: www.embopress.org/doi/full/10....
embopress.org
What’s in our bin?: Labs kick off and demand the transition towards a circular economy for lab plastics: EMBO reports: Vol 26, No 2
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
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Adrian Liston @labliston.bsky.social · 17/01/2025
Academics get so jaded about institutions, when they reach a #leadership position many feel #researchculture is unactionable. Me and @deefitzgerald.bsky.social wrote a guide in @immunolcellbiol.bsky.social on leadership nurturing a positive culture 1/13 onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library
Positive research cultures provide the environment for scientists to explore ideas, grow as individuals, develop team science and create a positive impact on those around them. Here we focus on key a...
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Kaiwen Chen @kaiwenchen-lab.bsky.social · 16/01/2025
Thrilled to start 2025 with our latest findings! Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive. www.cell.com/cell-reports...
cell.com
Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection
Injection of YopJ by Yersinia pseudotuberculosis triggers RIPK1-dependent caspase-8 and GSDMD activation in murine macrophages; however, how macrophages defend against Yersinia when caspase-8 or YopJ ...
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Rebecca Drummond 🍄 @therad-lab.bsky.social · 16/12/2024
There's still time to apply for this postdoc position in our lab. Ideally suited to someone wanting to develop some independent research, we have lots of new projects to select from! #immunosky 🧪
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Inflammasome Lab @inflammasomelab.bsky.social · 09/12/2024
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies! Link: rdcu.be/d2mjm
rdcu.be
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...
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(not) Imran Khan @imrsankhan.bsky.social · 03/12/2024
Preprint alert! Peptides are everywhere in biological environments, and these molecules serve as a rich source of nutrients for bacteria. Here, we uncover how one transporter protein allows S. aureus to utilise 100+ peptides for growth www.biorxiv.org/content/10.1...
biorxiv.org
Distinct roles for the Staphylococcus aureus POT transporter DtpT in di/tripeptide uptake and glutathione utilisation inside human macrophages
Peptides available in biological niches inhabited by the human pathogen Staphylococcus aureus serve as a rich source of amino acids required for growth and successful host colonisation. Uptake of pept...
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Gavin Thomas (he/him) @gavinhthomas.bsky.social · 03/12/2024
Another preprint, and this time the excellent work of @imrsankhan.bsky.social from his PhD & our first full experimental Staph aureus paper - on transporters of course! Imran found a cool link to glutathione and infection too. www.biorxiv.org/content/10.1...
biorxiv.org
Distinct roles for the Staphylococcus aureus POT transporter DtpT in di/tripeptide uptake and glutathione utilisation inside human macrophages
Peptides available in biological niches inhabited by the human pathogen Staphylococcus aureus serve as a rich source of amino acids required for growth and successful host colonisation. Uptake of pept...
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Clive McKimmie @clive-mckimmie.bsky.social · 08/11/2024
Excited by viruses and how our bodies repel them? A fully funded PhD project now available combining expertise from the lab to the clinic. #virology #immunology #dermatology #CRISPR #vector-vertebrate biology. Help us spread the word. ☺️ www.findaphd.com/phds/project...
findaphd.com
MRC DiMeN Doctoral Training Partnership: Can skin inflammation stop mosquito-borne virus infection? at University of York on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Can skin inflammation stop mosquito-borne virus infection? at University of York, listed on FindAPhD.com
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Ines Hahn @exdrososcientia.bsky.social · 06/11/2024
📢 PhD Alert! Join us for an exciting PhD project in gorgeous York 🧠 🔬 You will be based in the Hahnlab (sites.google.com/york.ac.uk/hah…) in gorgeous York & work with an interdisciplinary team of researchers. Happy to chat! Apply here: lnkd.in/es-nY8uD #PhDposition
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Proteases and Innate immunity lab @ York @protinnimmunity.bsky.social · 22/11/2024
PhD project with Ioannis Kourtzelis, our lab and Mesenbio in lovely York! Macrophage, EV and innate immune responses, what's not to love! www.findaphd.com/phds/project...
findaphd.com
CASE Project: Unravelling the role of extracellular vesicles in the orchestration of macrophage – mediated immune regulation. at University of York on FindAPhD.com
PhD Project - CASE Project: Unravelling the role of extracellular vesicles in the orchestration of macrophage – mediated immune regulation. at University of York, listed on FindAPhD.com
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Proteases and Innate immunity lab @ York @protinnimmunity.bsky.social · 18/11/2024
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Juan S. Bonifacino @juanbonifacino.bsky.social · 17/11/2024
Here are some free/open-source sites for the preparation of scientific illustrations, including icon libraries: bioicons.com, scidraw.io, bioart.niaid.nih.gov, inkscape.org, biogdp.com, reactome.org/icon-lib
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Proteases and Innate immunity lab @ York @protinnimmunity.bsky.social · 18/11/2024
go.bsky.app/221DCXf
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Itai Yanai @itaiyanai.bsky.social · 17/11/2024
We need to have a ‘code of conduct’ for reviewing manuscripts, like (1) if you say that something is not novel then provide the reference. (2) If you propose an experiment, state precisely to which claim it is crucial. (3) If you want to say something nasty then sign your name.
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