L'équipe du Pr Petr Broz, au Département d'immunobiologie de l’Unil, a identifié un mécanisme jusqu'alors inconnu par lequel le système immunitaire détecte l'endotoxine, un composant clé des membranes...

Cette année, trois jeunes scientifiques viennent renforcer la Faculté de biologie et de médecine (FBM) de l’Unil. Lauréat·es des subsides Ambizione du Fonds national suisse, Ella Hartenian, David Robe...

imageimageThe innate immune sensor NLRP6 is known to control host defense against bacteria and viruses in the gastrointestinal tract by a poorly-understood mechanism. This study shows that NLRP6 forms...

The EMBO Journal - The ability of intracellular bacteria to spread directly from one cell to the next, avoiding extracellular immune defenses and drugs, is essential for pathogen dissemination and,...

imageimageNINJ1 blocks HSV-1 entry into mouse macrophages independent of its role in cell death, resulting in greater secretion of pro inflammatory cytokines downstream of infection. Mouse macrophages lacking NINJ1 are more permissive to HSV-1 ...

A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...

A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for epithelial colonization.

Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...

Analysis of inflammasome responses in human macrophages reveals that inflammatory caspases and pyroptotic factors control Salmonella replication primarily within the cytosol and also within vacuoles.

Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.

TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.